SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dgf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1dgf CATALASE
(Homo
sapiens) 		5 / 12 GLY A  78
ALA A 123
GLY A 208
HIS A 209
THR A 115
 None
 1.03A 1gtnL-1dgfA:
undetectable
1gtnV-1dgfA:
undetectable		 1gtnL-1dgfA:
9.73
1gtnV-1dgfA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 1dgf CATALASE
(Homo
sapiens) 		3 / 3 ALA A 470
VAL A 182
TRP A 186
 None
 0.87A 1micA-1dgfA:
undetectable
1micB-1dgfA:
undetectable		 1micA-1dgfA:
4.41
1micB-1dgfA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1dgf CATALASE
(Homo
sapiens) 		5 / 12 HIS A 209
THR A 115
ILE A 205
GLY A  78
ALA A 123
 None
 0.91A 1utdL-1dgfA:
0.0
1utdM-1dgfA:
undetectable		 1utdL-1dgfA:
9.73
1utdM-1dgfA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1dgf CATALASE
(Homo
sapiens) 		3 / 3 ASP A  54
ASP A  59
ASP A  37
 None
 0.78A 2igtB-1dgfA:
undetectable		 2igtB-1dgfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 1dgf CATALASE
(Homo
sapiens) 		4 / 6 THR A 434
GLU A 191
MET A 350
ILE A 159
 None
None
HEM  A3000 (-3.7A)
None
 1.42A 2w98B-1dgfA:
undetectable		 2w98B-1dgfA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1dgf CATALASE
(Homo
sapiens) 		4 / 8 GLY A 131
ASN A 149
PHE A 154
ARG A 130
 HEM  A3000 (-3.6A)
None
None
None
 1.30A 3ccfA-1dgfA:
undetectable		 3ccfA-1dgfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NCQ_B_ACTB120_0
(NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2))		 1dgf CATALASE
(Homo
sapiens) 		4 / 4 MET A 350
LYS A 349
ASP A 348
ASP A 157
 HEM  A3000 (-3.7A)
None
None
None
 1.13A 3ncqB-1dgfA:
0.0		 3ncqB-1dgfA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1dgf CATALASE
(Homo
sapiens) 		5 / 9 LEU A 316
TYR A 236
VAL A 230
ILE A  91
LEU A 145
 None
 1.40A 3oxzA-1dgfA:
0.0		 3oxzA-1dgfA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 1dgf CATALASE
(Homo
sapiens) 		4 / 6 THR A 138
SER A  95
ASP A 144
THR A 107
 None
 1.08A 3q70A-1dgfA:
undetectable		 3q70A-1dgfA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1dgf CATALASE
(Homo
sapiens) 		5 / 11 LEU A  27
THR A  29
VAL A  35
LEU A  39
VAL A  41
 None
 1.41A 3tbgA-1dgfA:
0.0		 3tbgA-1dgfA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1dgf CATALASE
(Homo
sapiens) 		4 / 6 ASP A 257
GLY A 261
ASP A 124
THR A 125
 None
 1.02A 3vqrA-1dgfA:
undetectable		 3vqrA-1dgfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1dgf CATALASE
(Homo
sapiens) 		4 / 5 ASP A 257
GLY A 261
ASP A 124
THR A 125
 None
 0.98A 3vqrB-1dgfA:
undetectable		 3vqrB-1dgfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1dgf CATALASE
(Homo
sapiens) 		3 / 3 LYS A  77
THR A 115
ILE A 205
 None
 0.72A 4e0fB-1dgfA:
0.0		 4e0fB-1dgfA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1dgf CATALASE
(Homo
sapiens) 		4 / 6 GLY A 147
ASP A 144
PRO A 336
ARG A 354
 HEM  A3000 (-3.8A)
None
None
HEM  A3000 (-3.5A)
 1.10A 4lajA-1dgfA:
undetectable
4lajB-1dgfA:
undetectable		 4lajA-1dgfA:
19.96
4lajB-1dgfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1dgf CATALASE
(Homo
sapiens) 		4 / 6 GLY A 216
ASP A 144
PRO A 336
ARG A 354
 HEM  A3000 (-4.9A)
None
None
HEM  A3000 (-3.5A)
 0.97A 4lajA-1dgfA:
undetectable
4lajB-1dgfA:
undetectable		 4lajA-1dgfA:
19.96
4lajB-1dgfA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_A_HQEA503_1
(CATALASE)		 1dgf CATALASE
(Homo
sapiens) 		5 / 9 ASP A 128
PRO A 129
PHE A 154
LEU A 199
PHE A 200
 ACT  A5000 ( 4.9A)
None
None
None
None
 0.35A 4qopA-1dgfA:
56.4		 4qopA-1dgfA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_B_HQEB503_1
(CATALASE)		 1dgf CATALASE
(Homo
sapiens) 		5 / 9 ASP A 128
PRO A 129
PHE A 154
LEU A 199
PHE A 200
 ACT  A5000 ( 4.9A)
None
None
None
None
 0.36A 4qopB-1dgfA:
56.3		 4qopB-1dgfA:
46.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_C_HQEC503_1
(CATALASE)		 1dgf CATALASE
(Homo
sapiens) 		5 / 8 ASP A 128
PRO A 129
PHE A 154
LEU A 199
PHE A 200
 ACT  A5000 ( 4.9A)
None
None
None
None
 0.35A 4qopC-1dgfA:
56.3		 4qopC-1dgfA:
46.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1dgf CATALASE
(Homo
sapiens) 		4 / 7 MET A 212
HIS A  75
GLY A 147
ASN A 148
 None
HEM  A3000 (-3.4A)
HEM  A3000 (-3.8A)
HEM  A3000 (-3.4A)
 1.37A 5a5zC-1dgfA:
undetectable		 5a5zC-1dgfA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1dgf CATALASE
(Homo
sapiens) 		4 / 8 TYR A 358
ASP A 348
VAL A 146
GLY A 147
 HEM  A3000 (-3.9A)
None
HEM  A3000 (-4.7A)
HEM  A3000 (-3.8A)
 0.96A 5nzyA-1dgfA:
undetectable		 5nzyA-1dgfA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1dgf CATALASE
(Homo
sapiens) 		3 / 3 TYR A 489
ALA A 495
LEU A 496
 None
 0.51A 6ag0C-1dgfA:
undetectable		 6ag0C-1dgfA:
11.34