SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dgn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 1dgn ICEBERG (PROTEASE
INHIBITOR)
(Homo
sapiens) 		5 / 12 LEU A   5
ASP A   3
LEU A  89
ILE A  73
CYH A  69
 None
 1.17A 3ko0K-1dgnA:
undetectable
3ko0L-1dgnA:
undetectable
3ko0M-1dgnA:
undetectable
3ko0N-1dgnA:
undetectable		 3ko0K-1dgnA:
25.71
3ko0L-1dgnA:
25.71
3ko0M-1dgnA:
25.71
3ko0N-1dgnA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 1dgn ICEBERG (PROTEASE
INHIBITOR)
(Homo
sapiens) 		5 / 12 LEU A   5
ASP A   3
LEU A  89
ILE A  73
CYH A  69
 None
 1.19A 3ko0M-1dgnA:
undetectable
3ko0N-1dgnA:
undetectable
3ko0O-1dgnA:
undetectable
3ko0P-1dgnA:
undetectable		 3ko0M-1dgnA:
25.71
3ko0N-1dgnA:
25.71
3ko0O-1dgnA:
25.71
3ko0P-1dgnA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1dgn ICEBERG (PROTEASE
INHIBITOR)
(Homo
sapiens) 		5 / 8 GLY A  65
GLY A  63
SER A  68
ILE A  35
LEU A  57
 None
 1.21A 3v1nA-1dgnA:
undetectable		 3v1nA-1dgnA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1dgn ICEBERG (PROTEASE
INHIBITOR)
(Homo
sapiens) 		4 / 6 HIS A  75
LEU A  25
CYH A  69
CYH A  70
 None
 1.34A 5hrqD-1dgnA:
undetectable
5hrqG-1dgnA:
undetectable
5hrqH-1dgnA:
undetectable		 5hrqD-1dgnA:
14.93
5hrqG-1dgnA:
11.49
5hrqH-1dgnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1dgn ICEBERG (PROTEASE
INHIBITOR)
(Homo
sapiens) 		4 / 6 HIS A  75
LEU A  29
CYH A  69
CYH A  70
 None
 1.41A 5hrqD-1dgnA:
undetectable
5hrqG-1dgnA:
undetectable
5hrqH-1dgnA:
undetectable		 5hrqD-1dgnA:
14.93
5hrqG-1dgnA:
11.49
5hrqH-1dgnA:
14.93