SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dgp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 6 TYR A 129
GLU A 149
PRO A 148
VAL A 110
 None
 1.34A 1q13A-1dgpA:
undetectable		 1q13A-1dgpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 6 LYS A 321
LEU A  95
GLU A 324
ALA A 318
 None
 1.19A 1sn5A-1dgpA:
undetectable		 1sn5A-1dgpA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 7 LEU A 108
PHE A 112
LEU A 209
SER A 334
 FOH  A 402 (-4.2A)
FOH  A 402 ( 3.7A)
FOH  A 402 (-4.4A)
None
 0.95A 1wrlE-1dgpA:
0.0
1wrlF-1dgpA:
0.0		 1wrlE-1dgpA:
15.33
1wrlF-1dgpA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 5 ASP A 245
LEU A 287
LYS A 284
MET A 290
 FOH  A 401 (-3.5A)
None
None
None
 1.38A 2gj5A-1dgpA:
undetectable		 2gj5A-1dgpA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		5 / 12 TYR A 129
LEU A 133
ILE A 136
LEU A 153
VAL A 117
 None
 1.19A 2qo6A-1dgpA:
undetectable		 2qo6A-1dgpA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 8 LEU A 212
LEU A 107
THR A 175
LEU A 208
 None
None
None
FOH  A 402 ( 4.7A)
 0.80A 2xfhA-1dgpA:
0.7		 2xfhA-1dgpA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 5 LEU A 108
LEU A 212
MET A 160
THR A 175
 FOH  A 402 (-4.2A)
None
None
None
 1.46A 4do3A-1dgpA:
undetectable		 4do3A-1dgpA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 5 SER A 159
ARG A 106
LEU A 156
ASP A 155
 None
 1.05A 4ifxA-1dgpA:
0.0		 4ifxA-1dgpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 5 SER A 159
ARG A 106
LEU A 156
ASP A 155
 None
 1.07A 4ig1A-1dgpA:
0.0		 4ig1A-1dgpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		3 / 3 SER A 210
TYR A 319
PRO A 174
 None
 0.94A 4k8cA-1dgpA:
undetectable		 4k8cA-1dgpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		3 / 3 SER A 210
TYR A 319
PRO A 174
 None
 0.92A 4kahA-1dgpA:
undetectable		 4kahA-1dgpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		3 / 3 SER A 210
TYR A 319
PRO A 174
 None
 0.93A 4kahB-1dgpA:
undetectable		 4kahB-1dgpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		3 / 3 SER A 210
TYR A 319
PRO A 174
 None
 0.94A 4kanA-1dgpA:
undetectable		 4kanA-1dgpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		3 / 3 SER A 210
TYR A 319
PRO A 174
 None
 0.93A 4kanB-1dgpA:
undetectable		 4kanB-1dgpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		3 / 3 SER A 210
TYR A 319
PRO A 174
 None
 0.91A 4kbeA-1dgpA:
undetectable		 4kbeA-1dgpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		3 / 3 SER A 210
TYR A 319
PRO A 174
 None
 0.91A 4kbeB-1dgpA:
undetectable		 4kbeB-1dgpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		3 / 3 SER A 210
TYR A 319
PRO A 174
 None
 0.94A 4lbgA-1dgpA:
undetectable		 4lbgA-1dgpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		3 / 3 SER A 210
TYR A 319
PRO A 174
 None
 0.94A 4lbgB-1dgpA:
undetectable		 4lbgB-1dgpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		5 / 12 LEU A 167
GLY A 218
LEU A  97
MET A 160
HIS A  51
 None
 1.30A 4okbA-1dgpA:
1.6		 4okbA-1dgpA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 8 GLU A 201
ASP A 203
SER A 241
TRP A  46
 None
None
FOH  A 401 (-3.3A)
None
 1.20A 4uhxA-1dgpA:
undetectable		 4uhxA-1dgpA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 5 SER A 159
ARG A 106
LEU A 156
ASP A 155
 None
 1.47A 4xdtA-1dgpA:
0.0		 4xdtA-1dgpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 6 PRO A  41
ARG A 292
THR A 291
ILE A 246
 None
 1.25A 5ih0A-1dgpA:
undetectable		 5ih0A-1dgpA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		3 / 3 TYR A 319
LEU A 232
ASP A 299
 None
 0.86A 5zv2B-1dgpA:
undetectable		 5zv2B-1dgpA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 8 THR A  44
GLN A  45
THR A 296
GLU A 293
 None
 1.06A 6c06C-1dgpA:
0.0		 6c06C-1dgpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 7 ARG A 132
LEU A 113
TYR A 129
VAL A 110
 None
 1.28A 6g2pA-1dgpA:
undetectable		 6g2pA-1dgpA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 6 ILE A 190
GLY A 194
TYR A 196
GLU A 192
 None
 0.81A 6gqiA-1dgpA:
undetectable		 6gqiA-1dgpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		5 / 10 ALA A 104
LEU A 108
PHE A  65
ILE A 152
LEU A 156
 None
FOH  A 402 (-4.2A)
None
None
None
 1.42A 6h1lA-1dgpA:
1.2		 6h1lA-1dgpA:
21.46