SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dgr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1dgr CANAVALIN
(Canavalia
ensiformis) 		4 / 7 LEU X 265
TYR X 258
THR X 269
ASN X 299
 None
None
None
PO4  X1500 (-3.2A)
 1.04A 1afsA-1dgrX:
0.0		 1afsA-1dgrX:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1dgr CANAVALIN
(Canavalia
ensiformis) 		4 / 7 LEU X 265
TYR X 258
THR X 269
ASN X 299
 None
None
None
PO4  X1500 (-3.2A)
 1.03A 1afsB-1dgrX:
0.0		 1afsB-1dgrX:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1dgr CANAVALIN
(Canavalia
ensiformis) 		3 / 3 ILE X 268
LEU X 283
VAL Y 365
 None
 0.42A 1mz9B-1dgrX:
undetectable		 1mz9B-1dgrX:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1dgr CANAVALIN
(Canavalia
ensiformis) 		4 / 7 LEU A  99
PHE A 176
LEU A  67
SER A 106
 None
 0.99A 1wrlE-1dgrA:
undetectable
1wrlF-1dgrA:
undetectable		 1wrlE-1dgrA:
15.93
1wrlF-1dgrA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1dgr CANAVALIN
CANAVALIN
(Canavalia
ensiformis;
Canavalia
ensiformis) 		5 / 12 PHE A  51
ILE X 305
ASP A  85
ARG A  84
LEU A  83
 None
 1.30A 3iv6D-1dgrA:
undetectable		 3iv6D-1dgrA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1dgr CANAVALIN
(Canavalia
ensiformis) 		4 / 4 PRO X 256
LEU X 265
HIS X 297
LEU Y 379
 None
None
PO4  X1500 (-4.1A)
None
 1.38A 3vw7A-1dgrX:
undetectable		 3vw7A-1dgrX:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 1dgr CANAVALIN
(Canavalia
ensiformis) 		5 / 11 LEU A  69
GLU A 173
LEU A  89
ALA A 163
SER A 106
 None
 1.06A 4wnuA-1dgrA:
undetectable		 4wnuA-1dgrA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1dgr CANAVALIN
CANAVALIN
(Canavalia
ensiformis;
Canavalia
ensiformis) 		4 / 7 HIS X 297
ILE Y 348
VAL X 304
ARG Y 376
 PO4  X1500 (-4.1A)
PO4  X1500 ( 4.2A)
PO4  X1500 ( 4.8A)
PO4  X1500 (-3.7A)
 1.21A 5kkzC-1dgrX:
0.0
5kkzE-1dgrX:
undetectable		 5kkzC-1dgrX:
15.85
5kkzE-1dgrX:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1dgr CANAVALIN
CANAVALIN
(Canavalia
ensiformis;
Canavalia
ensiformis) 		4 / 7 ILE Y 348
VAL X 304
ARG Y 376
HIS X 297
 PO4  X1500 ( 4.2A)
PO4  X1500 ( 4.8A)
PO4  X1500 (-3.7A)
PO4  X1500 (-4.1A)
 1.21A 5kkzK-1dgrY:
undetectable
5kkzQ-1dgrY:
0.0		 5kkzK-1dgrY:
12.34
5kkzQ-1dgrY:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1dgr CANAVALIN
CANAVALIN
(Canavalia
ensiformis;
Canavalia
ensiformis) 		4 / 7 HIS X 297
ILE Y 348
VAL X 304
ARG Y 376
 PO4  X1500 (-4.1A)
PO4  X1500 ( 4.2A)
PO4  X1500 ( 4.8A)
PO4  X1500 (-3.7A)
 1.23A 5kkzM-1dgrX:
0.0
5kkzO-1dgrX:
undetectable		 5kkzM-1dgrX:
15.85
5kkzO-1dgrX:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 1dgr CANAVALIN
(Canavalia
ensiformis) 		5 / 9 ASN X 299
GLY Y 366
ILE Y 367
THR X 269
PRO X 270
 PO4  X1500 (-3.2A)
None
None
None
None
 1.29A 5kr2C-1dgrX:
undetectable		 5kr2C-1dgrX:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 1dgr CANAVALIN
CANAVALIN
(Canavalia
ensiformis;
Canavalia
ensiformis) 		8 / 8 ASN X 284
LEU X 286
HIS X 297
ASN X 299
VAL X 304
LEU X 306
ILE Y 348
ARG Y 376
 PO4  X1500 ( 4.0A)
None
PO4  X1500 (-4.1A)
PO4  X1500 (-3.2A)
PO4  X1500 ( 4.8A)
None
PO4  X1500 ( 4.2A)
PO4  X1500 (-3.7A)
 0.33A 6cb4A-1dgrX:
3.9		 6cb4A-1dgrX:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA502_0
(CANAVALIN)		 1dgr CANAVALIN
(Canavalia
ensiformis) 		4 / 4 GLY X 263
LYS X 264
GLN X 287
ASN X 289
 None
 0.37A 6cb4A-1dgrX:
3.9		 6cb4A-1dgrX:
27.43