SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 8 LEU A 365
HIS A 357
VAL A 191
GLU A 384
 None
 1.05A 1jtvA-1dgsA:
undetectable		 1jtvA-1dgsA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 12 GLY A  65
ARG A  18
ARG A  14
LEU A  44
GLU A  48
 None
 1.26A 1mj2A-1dgsA:
undetectable
1mj2B-1dgsA:
undetectable		 1mj2A-1dgsA:
10.53
1mj2B-1dgsA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 12 GLY A  65
ARG A  18
ARG A  14
LEU A  44
GLU A  48
 None
 1.26A 1mj2C-1dgsA:
undetectable
1mj2D-1dgsA:
undetectable		 1mj2C-1dgsA:
10.53
1mj2D-1dgsA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 12 GLY A  65
ARG A  18
ARG A  14
LEU A  44
GLU A  48
 None
 1.28A 1mjoC-1dgsA:
undetectable
1mjoD-1dgsA:
undetectable		 1mjoC-1dgsA:
10.53
1mjoD-1dgsA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 6 LYS A 213
ALA A 212
LEU A 216
VAL A  26
 None
 1.12A 1sn5A-1dgsA:
0.0		 1sn5A-1dgsA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 11 VAL A 547
VAL A 544
GLU A 539
GLU A 549
LEU A 556
 None
 1.47A 1t6zA-1dgsA:
undetectable		 1t6zA-1dgsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 5 LEU A 469
LEU A 472
LEU A 492
LEU A 491
 None
 1.01A 2ab2B-1dgsA:
0.0		 2ab2B-1dgsA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 6 ASP A 118
TYR A 171
PHE A 192
LEU A 180
 None
 1.22A 2w98A-1dgsA:
undetectable
2w98B-1dgsA:
undetectable		 2w98A-1dgsA:
20.99
2w98B-1dgsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 8 LEU A 244
LEU A 164
LEU A 234
ARG A 167
 None
 0.98A 2xn3A-1dgsA:
0.0
2xn3B-1dgsA:
0.0		 2xn3A-1dgsA:
19.73
2xn3B-1dgsA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		3 / 3 PRO A 403
LEU A 413
ARG A 421
 None
 0.60A 3aqiA-1dgsA:
undetectable		 3aqiA-1dgsA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		3 / 3 PRO A 403
LEU A 413
ARG A 421
 None
 0.82A 3aqiB-1dgsA:
undetectable		 3aqiB-1dgsA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		3 / 3 GLU A 256
HIS A 253
HIS A 115
 None
AMP  A 700 (-4.0A)
None
 0.76A 3co4A-1dgsA:
undetectable		 3co4A-1dgsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 4 LEU A 426
PRO A 425
LEU A 567
ARG A 569
 None
 1.39A 3hcoB-1dgsA:
undetectable		 3hcoB-1dgsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 6 ALA A 378
ILE A 382
VAL A 191
HIS A 357
 None
 1.04A 3nneG-1dgsA:
undetectable		 3nneG-1dgsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1dgs DNA LIGASE
(Thermus
filiformis) 		3 / 3 LYS A 418
ARG A 187
LYS A 193
 None
 1.34A 3okxA-1dgsA:
0.0		 3okxA-1dgsA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 11 GLU A 114
LYS A 116
GLU A 169
VAL A 286
LYS A 288
 AMP  A 700 (-3.7A)
AMP  A 700 (-1.5A)
AMP  A 700 (-3.6A)
None
AMP  A 700 ( 3.7A)
 1.07A 3qwuB-1dgsA:
10.8		 3qwuB-1dgsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 6 ARG A 214
GLN A 205
PHE A 192
LEU A 184
 None
 1.36A 3tgvD-1dgsA:
0.0		 3tgvD-1dgsA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 9 LEU A 123
PRO A 154
THR A 152
ILE A 150
PHE A 220
 None
 1.28A 3tvxA-1dgsA:
undetectable		 3tvxA-1dgsA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 1dgs DNA LIGASE
(Thermus
filiformis) 		3 / 3 ASP A  38
GLY A  65
TYR A  37
 None
 0.68A 3w9tC-1dgsA:
0.0		 3w9tC-1dgsA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 1dgs DNA LIGASE
(Thermus
filiformis) 		3 / 3 ASP A  38
GLY A  65
TYR A  37
 None
 0.68A 3w9tG-1dgsA:
0.0		 3w9tG-1dgsA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 8 LEU A 503
MET A 578
TYR A 470
TYR A 438
 None
 1.25A 3wipF-1dgsA:
0.0
3wipJ-1dgsA:
0.0		 3wipF-1dgsA:
13.79
3wipJ-1dgsA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 12 LEU A 157
PHE A 249
PRO A 161
GLY A 224
LEU A 223
 None
 1.21A 4j7xB-1dgsA:
undetectable		 4j7xB-1dgsA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1dgs DNA LIGASE
(Thermus
filiformis) 		3 / 3 GLU A 347
ARG A 275
HIS A 276
 None
 0.70A 4kf9A-1dgsA:
undetectable		 4kf9A-1dgsA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 6 GLU A 189
VAL A 210
THR A 211
ARG A 214
 None
 1.26A 4lnxA-1dgsA:
0.0		 4lnxA-1dgsA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 9 ALA A 552
ALA A 554
LEU A 512
SER A 537
LEU A 538
 None
 1.37A 4or0A-1dgsA:
undetectable		 4or0A-1dgsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 5 THR A 149
THR A 211
THR A  72
ASN A  21
 None
 1.38A 4pgfB-1dgsA:
undetectable		 4pgfB-1dgsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 12 ASP A 371
LEU A 322
LEU A 356
LEU A 365
ILE A 367
 None
 0.99A 4x1fA-1dgsA:
0.0		 4x1fA-1dgsA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 12 ASP A 371
LEU A 322
LEU A 356
LEU A 365
ILE A 367
 None
 1.00A 4x1gA-1dgsA:
0.0		 4x1gA-1dgsA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 5 GLU A  98
ALA A 107
GLU A 102
GLU A 262
 None
 1.49A 5dwkC-1dgsA:
2.4		 5dwkC-1dgsA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 7 GLY A 119
SER A 121
GLY A 135
ALA A 199
 None
 0.81A 5e26C-1dgsA:
0.0
5e26D-1dgsA:
0.0		 5e26C-1dgsA:
22.58
5e26D-1dgsA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 5 THR A 211
ALA A 212
THR A 149
TYR A  22
 None
 1.28A 5ecmA-1dgsA:
undetectable		 5ecmA-1dgsA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 5 LEU A 506
TYR A 508
LEU A 510
TYR A 438
 None
 1.20A 5ki6A-1dgsA:
undetectable		 5ki6A-1dgsA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 6 GLU A 549
ARG A 553
ALA A 552
LEU A 550
 None
 1.14A 5phhA-1dgsA:
0.0		 5phhA-1dgsA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 10 LEU A 147
LEU A 203
SER A 202
LEU A 216
VAL A 170
 None
 1.13A 5twjB-1dgsA:
undetectable		 5twjB-1dgsA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 12 LEU A 147
LEU A 203
SER A 202
LEU A 216
VAL A 170
 None
 1.14A 5twjC-1dgsA:
undetectable		 5twjC-1dgsA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 11 LEU A 147
ILE A 153
LEU A 203
SER A 202
LEU A 216
 None
 0.90A 5twjD-1dgsA:
undetectable		 5twjD-1dgsA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 5 THR A 219
GLU A 114
THR A 112
LEU A 242
 None
AMP  A 700 (-3.7A)
None
None
 1.25A 5utuH-1dgsA:
2.3		 5utuH-1dgsA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		3 / 3 THR A 132
THR A 144
ARG A  18
 None
 0.95A 5wm2A-1dgsA:
undetectable		 5wm2A-1dgsA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 5 ARG A 532
MET A 530
THR A 529
LEU A 503
 None
 1.22A 5x19J-1dgsA:
0.0		 5x19J-1dgsA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 5 ARG A 532
MET A 530
THR A 529
LEU A 503
 None
 1.18A 5x1bJ-1dgsA:
0.0		 5x1bJ-1dgsA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 10 LEU A 123
SER A 121
LEU A 120
ILE A 153
PRO A 250
 None
None
AMP  A 700 ( 4.7A)
None
None
 1.21A 6dlzB-1dgsA:
4.7
6dlzC-1dgsA:
3.1		 6dlzB-1dgsA:
7.75
6dlzC-1dgsA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 11 ILE A 153
PRO A 250
LEU A 123
SER A 121
LEU A 120
 None
None
None
None
AMP  A 700 ( 4.7A)
 1.22A 6dlzA-1dgsA:
2.9
6dlzD-1dgsA:
2.8		 6dlzA-1dgsA:
7.75
6dlzD-1dgsA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 10 LEU A 123
SER A 121
LEU A 120
ILE A 153
PRO A 250
 None
None
AMP  A 700 ( 4.7A)
None
None
 1.20A 6dm1B-1dgsA:
4.7
6dm1C-1dgsA:
3.0		 6dm1B-1dgsA:
7.75
6dm1C-1dgsA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 11 ILE A 153
PRO A 250
LEU A 123
SER A 121
LEU A 120
 None
None
None
None
AMP  A 700 ( 4.7A)
 1.21A 6dm1A-1dgsA:
3.0
6dm1D-1dgsA:
2.9		 6dm1A-1dgsA:
7.75
6dm1D-1dgsA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 10 LEU A 123
SER A 121
LEU A 120
ILE A 153
PRO A 250
 None
None
AMP  A 700 ( 4.7A)
None
None
 1.19A 6dm2B-1dgsA:
2.8
6dm2C-1dgsA:
2.6		 6dm2B-1dgsA:
7.75
6dm2C-1dgsA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1dgs DNA LIGASE
(Thermus
filiformis) 		5 / 10 ILE A 153
PRO A 250
LEU A 123
SER A 121
LEU A 120
 None
None
None
None
AMP  A 700 ( 4.7A)
 1.19A 6dm2A-1dgsA:
3.0
6dm2D-1dgsA:
2.9		 6dm2A-1dgsA:
7.75
6dm2D-1dgsA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 7 ASP A 445
ARG A 505
GLN A 494
TYR A 438
 None
 1.24A 6g31G-1dgsA:
3.4		 6g31G-1dgsA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1dgs DNA LIGASE
(Thermus
filiformis) 		4 / 5 ARG A 505
ALA A 443
TYR A 438
ILE A 446
 None
 1.47A 6g9bA-1dgsA:
0.0
6g9bB-1dgsA:
0.0		 6g9bA-1dgsA:
8.21
6g9bB-1dgsA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1dgs DNA LIGASE
(Thermus
filiformis) 		3 / 3 TRP A 402
ILE A 362
GLU A 185
 None
 0.78A 6hcxA-1dgsA:
undetectable		 6hcxA-1dgsA:
7.10