SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dhr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F78_A_BEZA1003_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	1dhr	DIHYDROPTERIDINE REDUCTASE (Rattus norvegicus)	4 / 7	VAL A 176 LEU A 18 PHE A 203 THR A 199	None NAD A 241 (-4.1A) None None	1.13A	2f78A-1dhrA: 0.3	2f78A-1dhrA: 23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F78_B_BEZB1004_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	1dhr	DIHYDROPTERIDINE REDUCTASE (Rattus norvegicus)	4 / 7	VAL A 176 LEU A 18 PHE A 203 THR A 199	None NAD A 241 (-4.1A) None None	1.17A	2f78B-1dhrA: 0.3	2f78B-1dhrA: 23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMM_A_SAMA301_0 (UPF0217 PROTEIN AF_1056)	1dhr	DIHYDROPTERIDINE REDUCTASE (Rattus norvegicus)	5 / 9	LEU A 223 GLY A 132 SER A 222 SER A 220 CYH A 157	None	1.16A	2qmmA-1dhrA: 2.5	2qmmA-1dhrA: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BXM_A_SAMA402_0 (DIPHTHAMIDE BIOSYNTHESIS ENZYME DPH2)	1dhr	DIHYDROPTERIDINE REDUCTASE (Rattus norvegicus)	5 / 12	GLY A 19 LEU A 70 VAL A 67 ILE A 36 ASP A 37	None None None None NAD A 241 (-2.8A)	1.08A	6bxmA-1dhrA: 2.6	6bxmA-1dhrA: 22.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2F78_A_BEZA1003_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","1dhr","DIHYDROPTERIDINE REDUCTASE","Rattus norvegicus",4,"VAL A 176;LEU A  18;PHE A 203;THR A 199","None;NAD A 241 (-4.1A);None;None","1.13A","2f78A-1dhrA:0.3","2f78A-1dhrA:23.51"],["2F78_B_BEZB1004_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","1dhr","DIHYDROPTERIDINE REDUCTASE","Rattus norvegicus",4,"VAL A 176;LEU A  18;PHE A 203;THR A 199","None;NAD A 241 (-4.1A);None;None","1.17A","2f78B-1dhrA:0.3","2f78B-1dhrA:23.51"],["2QMM_A_SAMA301_0","UPF0217 PROTEIN AF_1056","1dhr","DIHYDROPTERIDINE REDUCTASE","Rattus norvegicus",5,"LEU A 223;GLY A 132;SER A 222;SER A 220;CYH A 157","None","1.16A","2qmmA-1dhrA:2.5","2qmmA-1dhrA:21.05"],["6BXM_A_SAMA402_0","DIPHTHAMIDE BIOSYNTHESIS ENZYME DPH2","1dhr","DIHYDROPTERIDINE REDUCTASE","Rattus norvegicus",5,"GLY A  19;LEU A  70;VAL A  67;ILE A  36;ASP A  37","None;None;None;None;NAD A 241 (-2.8A)","1.08A","6bxmA-1dhrA:2.6","6bxmA-1dhrA:22.52"]]