SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 THR A 130
ILE A 290
TYR A 103
VAL A 129
LEU A 101
 None
 1.23A 1z9hD-1dhsA:
0.0		 1z9hD-1dhsA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 9 LEU A 281
ILE A 279
PHE A 347
LEU A 119
ILE A 116
 None
 1.19A 2f78A-1dhsA:
0.0		 2f78A-1dhsA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 9 LEU A 281
ILE A 279
PHE A 347
LEU A 119
ILE A 116
 None
 1.23A 2f78B-1dhsA:
undetectable		 2f78B-1dhsA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 SER A 110
ILE A 112
ILE A 116
LEU A 281
ASN A 307
 None
 1.01A 2nnhA-1dhsA:
0.2		 2nnhA-1dhsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 SER A 110
ILE A 112
LEU A 281
ASN A 307
VAL A 286
 None
 0.91A 2nnhA-1dhsA:
0.2		 2nnhA-1dhsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 10 SER A 110
ILE A 112
ILE A 116
LEU A 281
ASN A 307
 None
 1.03A 2nnhB-1dhsA:
0.5		 2nnhB-1dhsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 10 SER A 110
ILE A 112
LEU A 281
ASN A 307
VAL A 286
 None
 0.94A 2nnhB-1dhsA:
0.5		 2nnhB-1dhsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 134
ARG A 113
ILE A 214
VAL A 120
ILE A 116
 None
 0.93A 3adxB-1dhsA:
0.0		 3adxB-1dhsA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A  60
GLU A  47
GLY A  50
ASN A  67
VAL A  63
 None
 0.98A 3nk7A-1dhsA:
2.4		 3nk7A-1dhsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		3 / 3 PRO A 203
THR A 202
LEU A 265
 None
 0.68A 3ttrA-1dhsA:
0.0		 3ttrA-1dhsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		4 / 7 VAL A 125
PHE A 355
VAL A  66
ILE A 290
 None
 0.93A 3zjqA-1dhsA:
0.0		 3zjqA-1dhsA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		4 / 7 VAL A 125
PHE A 355
VAL A  66
ILE A 290
 None
 0.96A 3zjqB-1dhsA:
0.0		 3zjqB-1dhsA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		4 / 6 THR A 130
GLY A 102
ILE A 290
LEU A 128
 None
 1.04A 4acbC-1dhsA:
undetectable		 4acbC-1dhsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 116
LEU A 128
GLY A 134
ILE A 108
ASN A 164
 None
 1.17A 4o1eB-1dhsA:
undetectable		 4o1eB-1dhsA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 GLU A 323
ASP A 316
LEU A 295
ASN A 292
HIS A 288
 None
 1.49A 4pgfA-1dhsA:
2.9		 4pgfA-1dhsA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 8 LEU A 350
VAL A 351
ILE A 112
ALA A 343
LEU A 281
 None
None
None
NAD  A 700 (-3.6A)
None
 1.14A 4qrcA-1dhsA:
undetectable		 4qrcA-1dhsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A  48
GLY A  50
THR A  57
ALA A  56
THR A  52
 None
 1.24A 4qvyV-1dhsA:
undetectable
4qvyW-1dhsA:
undetectable		 4qvyV-1dhsA:
22.62
4qvyW-1dhsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 11 ALA A  48
GLY A  50
THR A  57
ALA A  56
THR A  52
 None
 1.25A 4qw0H-1dhsA:
undetectable
4qw0I-1dhsA:
undetectable		 4qw0H-1dhsA:
22.62
4qw0I-1dhsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 11 ALA A  48
GLY A  50
THR A  57
ALA A  56
THR A  52
 None
 1.25A 4qw0V-1dhsA:
undetectable
4qw0W-1dhsA:
undetectable		 4qw0V-1dhsA:
22.62
4qw0W-1dhsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A  48
GLY A  50
THR A  57
ALA A  56
THR A  52
 None
 1.25A 4qw1H-1dhsA:
undetectable
4qw1I-1dhsA:
undetectable		 4qw1H-1dhsA:
22.62
4qw1I-1dhsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A  48
GLY A  50
THR A  57
ALA A  56
THR A  52
 None
 1.26A 4qw1V-1dhsA:
undetectable
4qw1W-1dhsA:
undetectable		 4qw1V-1dhsA:
22.62
4qw1W-1dhsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 179
ILE A 186
THR A 130
VAL A 231
LEU A 210
 None
 1.38A 4qzuA-1dhsA:
undetectable		 4qzuA-1dhsA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		4 / 8 THR A  52
GLU A  47
VAL A  40
GLY A  33
 None
 0.91A 4r3aA-1dhsA:
0.0		 4r3aA-1dhsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A  48
GLY A  50
THR A  57
ALA A  56
THR A  52
 None
 1.26A 5cz7V-1dhsA:
undetectable
5cz7W-1dhsA:
undetectable		 5cz7V-1dhsA:
22.62
5cz7W-1dhsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		4 / 5 ASP A 138
TRP A 223
VAL A 120
ALA A 224
 None
 1.49A 5dl9A-1dhsA:
undetectable		 5dl9A-1dhsA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 107
VAL A 286
ILE A 290
ALA A 291
PHE A 100
 NAD  A 700 (-4.6A)
None
None
None
None
 0.80A 5j2tC-1dhsA:
4.7		 5j2tC-1dhsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A  48
GLY A  50
THR A  57
ALA A  56
THR A  52
 None
 1.24A 5l66H-1dhsA:
undetectable
5l66I-1dhsA:
undetectable		 5l66H-1dhsA:
22.62
5l66I-1dhsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A  48
GLY A  50
THR A  57
ALA A  56
THR A  52
 None
 1.25A 5l66V-1dhsA:
undetectable
5l66W-1dhsA:
undetectable		 5l66V-1dhsA:
22.62
5l66W-1dhsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1dhs DEOXYHYPUSINE
SYNTHASE
(Homo
sapiens) 		3 / 3 ARG A  61
PRO A 336
TYR A 340
 None
 0.94A 5tzoB-1dhsA:
undetectable		 5tzoB-1dhsA:
19.84