SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1di6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		3 / 3 ARG A 104
GLU A 101
GLN A 119
 None
 1.06A 2p16A-1di6A:
undetectable		 2p16A-1di6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		5 / 12 LEU A  58
ILE A  11
PRO A  26
ILE A 139
PRO A 136
 None
 0.99A 2ygqA-1di6A:
0.0		 2ygqA-1di6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		5 / 12 THR A  76
VAL A  70
LEU A  61
ILE A 129
THR A  57
 SO4  A 201 (-2.8A)
None
None
None
None
 1.47A 3elzC-1di6A:
undetectable		 3elzC-1di6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		5 / 12 THR A  76
VAL A  70
LEU A  61
ILE A 129
THR A  57
 SO4  A 201 (-2.8A)
None
None
None
None
 1.34A 3em0B-1di6A:
undetectable		 3em0B-1di6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		5 / 12 GLY A 100
LEU A 128
VAL A 162
ILE A 158
LEU A  89
 None
 1.22A 3g9eA-1di6A:
0.0		 3g9eA-1di6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		4 / 7 TRP A  31
LEU A  69
LEU A 128
ILE A 158
 None
 1.02A 3u5jA-1di6A:
undetectable		 3u5jA-1di6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1480_0
(MJ0495-LIKE PROTEIN)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		4 / 4 LYS A  23
GLU A  29
ILE A  25
SER A  10
 None
 1.47A 4ac9C-1di6A:
4.0		 4ac9C-1di6A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		6 / 12 ILE A  25
ASP A  22
GLY A  24
THR A  44
LEU A  42
GLY A  74
 None
None
None
None
None
SO4  A 201 (-3.5A)
 1.35A 4e3aB-1di6A:
undetectable		 4e3aB-1di6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		4 / 7 THR A  76
THR A  88
LEU A  89
THR A  84
 SO4  A 201 (-2.8A)
None
None
None
 0.93A 4z91F-1di6A:
0.0
4z91G-1di6A:
0.0
4z91H-1di6A:
0.0
4z91I-1di6A:
0.0
4z91J-1di6A:
0.0		 4z91F-1di6A:
18.67
4z91G-1di6A:
18.67
4z91H-1di6A:
18.67
4z91I-1di6A:
18.67
4z91J-1di6A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		4 / 6 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.74A 5eckA-1di6A:
undetectable		 5eckA-1di6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		4 / 6 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.80A 5eckD-1di6A:
undetectable		 5eckD-1di6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		4 / 6 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.52A 5eclA-1di6A:
0.0		 5eclA-1di6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		4 / 6 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.62A 5eclD-1di6A:
0.0		 5eclD-1di6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		4 / 7 ALA A  87
THR A  88
VAL A  91
VAL A   9
 None
 0.72A 5ecoD-1di6A:
0.0		 5ecoD-1di6A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		3 / 3 GLU A 144
HIS A 156
VAL A 181
 None
 0.84A 5trqB-1di6A:
0.0		 5trqB-1di6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		5 / 12 ILE A 158
GLY A 100
PHE A  99
THR A  88
ALA A 114
 None
 1.20A 5x5qB-1di6A:
undetectable		 5x5qB-1di6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		5 / 12 VAL A  91
VAL A 120
GLY A 100
ASN A 131
VAL A  70
 None
 1.18A 6bqgA-1di6A:
undetectable		 6bqgA-1di6A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME
(Escherichia
coli) 		4 / 8 ILE A 115
THR A 113
GLU A 141
SER A 138
 None
 1.11A 6c06C-1di6A:
0.0		 6c06C-1di6A:
undetectable