SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		5 / 12 VAL A  31
ILE A  10
ALA A 247
GLY A 246
ILE A  77
 None
 0.93A 1bx4A-1dihA:
5.7		 1bx4A-1dihA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		6 / 12 GLY A  15
GLY A  14
VAL A  62
LEU A  44
ILE A  22
LEU A  21
 NDP  A 301 ( 3.5A)
NDP  A 301 ( 4.9A)
None
None
None
None
 1.26A 1mx1D-1dihA:
undetectable		 1mx1D-1dihA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		5 / 10 ALA A 222
THR A 221
HIS A 159
ALA A 171
THR A 170
 None
 1.20A 1r55A-1dihA:
3.7		 1r55A-1dihA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		4 / 8 SER A 250
LEU A  21
PHE A  79
SER A 130
 None
None
NDP  A 301 (-4.7A)
None
 0.98A 1wrlC-1dihA:
undetectable
1wrlD-1dihA:
undetectable		 1wrlC-1dihA:
16.73
1wrlD-1dihA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		4 / 8 VAL A 133
GLY A 169
THR A 170
ALA A 173
 None
 0.66A 3aruA-1dihA:
undetectable		 3aruA-1dihA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		3 / 3 SER A 168
GLY A 169
THR A 170
 None
 0.19A 3k9wA-1dihA:
3.8		 3k9wA-1dihA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		4 / 5 ILE A 101
THR A 103
THR A  80
PHE A 106
 None
NDP  A 301 (-4.1A)
NDP  A 301 ( 3.7A)
None
 1.22A 3snfA-1dihA:
undetectable		 3snfA-1dihA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		5 / 11 GLY A  14
ALA A  11
GLY A  12
VAL A  62
HIS A  88
 NDP  A 301 ( 4.9A)
None
NDP  A 301 ( 3.1A)
None
None
 1.30A 4c5lA-1dihA:
7.6		 4c5lA-1dihA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		5 / 10 GLY A  14
ALA A  11
GLY A  12
VAL A  62
HIS A  88
 NDP  A 301 ( 4.9A)
None
NDP  A 301 ( 3.1A)
None
None
 1.23A 4c5nD-1dihA:
7.5		 4c5nD-1dihA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		5 / 10 GLY A  15
ALA A  11
GLY A  12
VAL A  62
HIS A  88
 NDP  A 301 ( 3.5A)
None
NDP  A 301 ( 3.1A)
None
None
 1.42A 4c5nD-1dihA:
7.5		 4c5nD-1dihA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		4 / 7 GLY A  84
THR A  80
LEU A  66
PHE A  76
 NDP  A 301 ( 3.3A)
NDP  A 301 ( 3.7A)
None
None
 0.83A 4ejjD-1dihA:
0.0		 4ejjD-1dihA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		5 / 11 LEU A 268
LEU A 254
PHE A 129
ALA A 126
ASP A 263
 None
 1.37A 4wnuC-1dihA:
0.0		 4wnuC-1dihA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		5 / 12 VAL A  31
ILE A  10
ALA A 247
GLY A 246
ILE A  77
 None
 0.82A 5kb6A-1dihA:
5.8		 5kb6A-1dihA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1dih DIHYDRODIPICOLINATE
REDUCTASE
(Escherichia
coli) 		5 / 12 VAL A  31
ILE A  10
ALA A 247
GLY A 246
ILE A  77
 None
 0.82A 5kb6B-1dihA:
5.2		 5kb6B-1dihA:
21.58