SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1dk8 AXIN
(Homo
sapiens) 		4 / 8 PHE A 139
ARG A 140
ALA A 149
LEU A 152
 None
SO4  A 503 (-3.0A)
None
None
 0.85A 2o01A-1dk8A:
undetectable		 2o01A-1dk8A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1dk8 AXIN
(Homo
sapiens) 		5 / 11 TYR A 185
LEU A 143
ALA A 157
VAL A 193
THR A 234
 None
 1.42A 3jwqB-1dk8A:
2.2
3jwqC-1dk8A:
undetectable		 3jwqB-1dk8A:
21.80
3jwqC-1dk8A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG202_1
(PROTEIN S100-A4)		 1dk8 AXIN
(Homo
sapiens) 		5 / 10 ILE A 226
CYH A 158
PHE A 161
GLU A 225
ASP A 220
 None
 1.31A 3ko0E-1dk8A:
undetectable
3ko0F-1dk8A:
undetectable
3ko0G-1dk8A:
undetectable
3ko0H-1dk8A:
1.6		 3ko0E-1dk8A:
20.81
3ko0F-1dk8A:
20.81
3ko0G-1dk8A:
20.81
3ko0H-1dk8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1dk8 AXIN
(Homo
sapiens) 		4 / 7 TYR A 119
TYR A 244
PHE A 238
TYR A 235
 GOL  A 604 (-4.5A)
None
None
DTT  A 701 (-4.3A)
 1.37A 3ku9B-1dk8A:
undetectable		 3ku9B-1dk8A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 1dk8 AXIN
(Homo
sapiens) 		4 / 8 ILE A 214
GLU A 225
THR A 197
THR A 201
 None
 0.72A 5og9A-1dk8A:
undetectable		 5og9A-1dk8A:
14.23