SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dkg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		4 / 5 PHE D 200
VAL D 353
VAL D 192
ASP D 194
 None
 1.37A 1dz6B-1dkgD:
0.0		 1dz6B-1dkgD:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 12 ALA D 269
GLU D 272
LEU D 273
ILE D 286
LEU D 240
 None
 1.21A 1errA-1dkgD:
undetectable		 1errA-1dkgD:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 9 ALA D 153
GLY D 158
ILE D 160
ILE D  69
ILE D  73
 None
 0.73A 1hshB-1dkgD:
undetectable		 1hshB-1dkgD:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 8 ALA D 153
GLY D 158
ILE D 160
ILE D  69
ILE D  73
 None
 0.76A 1hshD-1dkgD:
undetectable		 1hshD-1dkgD:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1dkg MOLECULAR CHAPERONE
DNAK
NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 MET A 189
ILE D 286
ALA D 258
LEU D 257
ALA A 158
 None
 1.42A 1jb0B-1dkgA:
undetectable		 1jb0B-1dkgA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		3 / 3 LEU A  95
VAL A  98
LEU A 102
 None
 0.47A 1mz9B-1dkgA:
4.0		 1mz9B-1dkgA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		4 / 5 LEU A  96
MET A 130
LEU A 131
GLN A 175
 None
 1.28A 1p93D-1dkgA:
undetectable		 1p93D-1dkgA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		4 / 7 PHE D  67
PHE D  91
MET D  89
SER D  87
 None
 1.05A 1wrlE-1dkgD:
undetectable
1wrlF-1dkgD:
0.0		 1wrlE-1dkgD:
14.67
1wrlF-1dkgD:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 12 THR D 141
LEU D   9
ILE D 140
VAL D 165
PHE D 146
 None
 1.36A 1wsvA-1dkgD:
0.0		 1wsvA-1dkgD:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 12 LEU D 262
ALA D 265
ALA D 269
THR D 279
LEU D 308
 None
 1.09A 2fr3A-1dkgD:
undetectable		 2fr3A-1dkgD:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 12 ALA D 269
GLU D 272
LEU D 273
ILE D 286
LEU D 240
 None
 1.08A 2qxsA-1dkgD:
undetectable		 2qxsA-1dkgD:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		4 / 8 ASN D 170
THR D 173
LEU D 177
ALA D 375
 None
 1.01A 3kp6A-1dkgD:
undetectable		 3kp6A-1dkgD:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 12 THR A 191
THR A 145
GLY A 168
ALA A 193
SER A 162
 None
 1.12A 3mg02-1dkgA:
undetectable
3mg0V-1dkgA:
undetectable		 3mg02-1dkgA:
20.17
3mg0V-1dkgA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 9 ILE D 202
LEU D 227
PHE D 232
THR D  11
GLY D 229
 None
 1.45A 3nxuB-1dkgD:
0.0		 3nxuB-1dkgD:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1dkg MOLECULAR CHAPERONE
DNAK
NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 MET A 189
ILE D 286
ALA D 258
LEU D 257
ALA A 158
 None
 1.42A 3pcqB-1dkgA:
undetectable		 3pcqB-1dkgA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		6 / 12 ILE D 169
ILE D 373
GLY D 180
ASP D 182
ASP D 336
ILE D 190
 None
 1.29A 3tneB-1dkgD:
undetectable		 3tneB-1dkgD:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 12 VAL D  16
ILE D   5
ILE D  40
GLU D 118
VAL D 135
 None
 1.16A 4a97B-1dkgD:
0.1
4a97C-1dkgD:
0.0		 4a97B-1dkgD:
22.89
4a97C-1dkgD:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		3 / 3 ASN D 314
LEU D 195
PHE D 356
 None
 0.82A 4dajB-1dkgD:
0.0		 4dajB-1dkgD:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		4 / 8 GLY D 328
ALA D 327
ASP D 326
THR D 189
 None
 0.87A 4eyrB-1dkgD:
0.0		 4eyrB-1dkgD:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1dkg MOLECULAR CHAPERONE
DNAK
NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 9 MET A 189
ILE D 286
ALA D 258
LEU D 257
ALA A 158
 None
 1.42A 4fe1B-1dkgA:
undetectable		 4fe1B-1dkgA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.18A 4qvmV-1dkgA:
undetectable
4qvmb-1dkgA:
undetectable		 4qvmV-1dkgA:
19.58
4qvmb-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.19A 4qvmH-1dkgA:
undetectable
4qvmN-1dkgA:
undetectable		 4qvmH-1dkgA:
19.58
4qvmN-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 12 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.21A 4qvnV-1dkgA:
undetectable
4qvnb-1dkgA:
undetectable		 4qvnV-1dkgA:
19.58
4qvnb-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 12 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.22A 4qvnH-1dkgA:
undetectable
4qvnN-1dkgA:
undetectable		 4qvnH-1dkgA:
19.58
4qvnN-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.19A 4qvpV-1dkgA:
undetectable
4qvpb-1dkgA:
undetectable		 4qvpV-1dkgA:
19.58
4qvpb-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.19A 4qvpH-1dkgA:
undetectable
4qvpN-1dkgA:
undetectable		 4qvpH-1dkgA:
19.58
4qvpN-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.19A 4qvqV-1dkgA:
undetectable
4qvqb-1dkgA:
undetectable		 4qvqV-1dkgA:
19.58
4qvqb-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.20A 4qvqH-1dkgA:
undetectable
4qvqN-1dkgA:
undetectable		 4qvqH-1dkgA:
19.58
4qvqN-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.20A 4qvwV-1dkgA:
undetectable
4qvwb-1dkgA:
undetectable		 4qvwV-1dkgA:
19.58
4qvwb-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.20A 4qvwH-1dkgA:
undetectable
4qvwN-1dkgA:
undetectable		 4qvwH-1dkgA:
19.58
4qvwN-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.19A 4qw0V-1dkgA:
undetectable
4qw0b-1dkgA:
undetectable		 4qw0V-1dkgA:
19.58
4qw0b-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.19A 4qw0H-1dkgA:
undetectable
4qw0N-1dkgA:
undetectable		 4qw0H-1dkgA:
19.58
4qw0N-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.20A 4qw1H-1dkgA:
undetectable
4qw1N-1dkgA:
undetectable		 4qw1H-1dkgA:
19.58
4qw1N-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.19A 4qw3V-1dkgA:
undetectable
4qw3b-1dkgA:
undetectable		 4qw3V-1dkgA:
19.58
4qw3b-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.20A 4qw3H-1dkgA:
undetectable
4qw3N-1dkgA:
undetectable		 4qw3H-1dkgA:
19.58
4qw3N-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		4 / 7 GLU D 171
THR D  11
GLY D  10
THR D  12
 None
 0.96A 4qwpB-1dkgD:
undetectable		 4qwpB-1dkgD:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 9 ASP D   8
GLY D 374
ALA D 174
THR D 173
VAL D 192
 None
 1.26A 4r1zA-1dkgD:
undetectable		 4r1zA-1dkgD:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		4 / 7 PRO D  53
GLU D  31
SER D  38
THR D 141
 None
 1.24A 4uacA-1dkgD:
0.0		 4uacA-1dkgD:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1dkg MOLECULAR CHAPERONE
DNAK
NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 10 MET A 189
ILE D 286
ALA D 258
LEU D 257
ALA A 158
 None
 1.40A 4xk8B-1dkgA:
0.8		 4xk8B-1dkgA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		4 / 5 ARG D 362
PRO D 361
ILE D 338
ASP D 336
 None
 1.40A 4z4hA-1dkgD:
5.6		 4z4hA-1dkgD:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 11 ALA D 138
GLY D 158
VAL D 135
GLU D 128
LEU D 131
 None
 1.16A 4zmeA-1dkgD:
undetectable		 4zmeA-1dkgD:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		6 / 10 GLY D 197
GLY D 229
LYS D 270
SER D 274
GLY D 342
ARG D 345
 None
 0.91A 5aqfA-1dkgD:
52.1		 5aqfA-1dkgD:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		6 / 10 GLY D 197
GLY D 229
LYS D 270
SER D 274
GLY D 342
ARG D 345
 None
 0.91A 5aqfC-1dkgD:
52.0		 5aqfC-1dkgD:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		6 / 10 GLY D 197
GLY D 229
LYS D 270
SER D 274
GLY D 342
ARG D 345
 None
 0.93A 5aqyA-1dkgD:
53.4		 5aqyA-1dkgD:
53.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.19A 5cz7H-1dkgA:
undetectable
5cz7N-1dkgA:
undetectable		 5cz7H-1dkgA:
19.58
5cz7N-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.18A 5d0xV-1dkgA:
undetectable
5d0xb-1dkgA:
undetectable		 5d0xV-1dkgA:
19.58
5d0xb-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.19A 5d0xH-1dkgA:
undetectable
5d0xN-1dkgA:
undetectable		 5d0xH-1dkgA:
19.58
5d0xN-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		4 / 8 MET D 296
LEU D 283
LEU D 257
LEU D 252
 None
 1.07A 5dxeA-1dkgD:
undetectable		 5dxeA-1dkgD:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 12 ALA D 153
GLY D 158
ILE D 160
ILE D  69
ILE D  73
 None
 0.80A 5e5jA-1dkgD:
undetectable		 5e5jA-1dkgD:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 12 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.18A 5l5zV-1dkgA:
undetectable
5l5zb-1dkgA:
undetectable		 5l5zV-1dkgA:
19.58
5l5zb-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 12 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.20A 5l5zH-1dkgA:
undetectable
5l5zN-1dkgA:
undetectable		 5l5zH-1dkgA:
19.58
5l5zN-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 11 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.19A 5l66V-1dkgA:
undetectable
5l66b-1dkgA:
undetectable		 5l66V-1dkgA:
19.58
5l66b-1dkgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1dkg MOLECULAR CHAPERONE
DNAK
NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 10 MET A 189
ILE D 286
ALA D 258
LEU D 257
ALA A 158
 None
 1.45A 5zjiB-1dkgA:
undetectable		 5zjiB-1dkgA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 12 PRO D  24
GLY D   6
ALA D  17
ALA D 375
ALA D 174
 None
 1.05A 5zw4A-1dkgD:
undetectable		 5zw4A-1dkgD:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		4 / 8 MET D 296
LEU D 283
LEU D 257
LEU D 252
 None
 1.07A 6cbzA-1dkgD:
undetectable		 6cbzA-1dkgD:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		5 / 12 ALA D 153
GLY D 158
ILE D 160
ILE D  69
ILE D  73
 None
 0.80A 6dh3A-1dkgD:
undetectable		 6dh3A-1dkgD:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 12 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.21A 6hwdV-1dkgA:
undetectable
6hwdb-1dkgA:
undetectable		 6hwdV-1dkgA:
15.98
6hwdb-1dkgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
(Escherichia
coli) 		5 / 12 SER A 162
THR A 191
THR A 145
GLY A 168
ALA A 193
 None
 1.20A 6hwdH-1dkgA:
undetectable
6hwdN-1dkgA:
undetectable		 6hwdH-1dkgA:
15.98
6hwdN-1dkgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
MOLECULAR CHAPERONE
DNAK
(Escherichia
coli;
Escherichia
coli) 		4 / 8 ASP A 150
ARG D  56
HIS A 154
GLU D  31
 None
 1.24A 6mn4B-1dkgA:
0.0		 6mn4B-1dkgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE
MOLECULAR CHAPERONE
DNAK
(Escherichia
coli;
Escherichia
coli) 		4 / 8 ASP A 150
ARG D  56
HIS A 154
GLU D  31
 None
 1.32A 6mn4C-1dkgA:
undetectable		 6mn4C-1dkgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1dkg MOLECULAR CHAPERONE
DNAK
(Escherichia
coli) 		4 / 5 ARG D 235
LEU D 312
GLN D 343
PHE D 200
 None
 1.48A 6nmpP-1dkgD:
0.7
6nmpW-1dkgD:
0.0		 6nmpP-1dkgD:
20.15
6nmpW-1dkgD:
10.23