SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 10 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
 None
 1.29A 1a52B-1dkpA:
undetectable		 1a52B-1dkpA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 9 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
 None
 1.30A 1ereA-1dkpA:
undetectable		 1ereA-1dkpA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 9 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
 None
 1.29A 1ereB-1dkpA:
undetectable		 1ereB-1dkpA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 9 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
 None
 1.30A 1ereC-1dkpA:
undetectable		 1ereC-1dkpA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 9 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
 None
 1.28A 1ereD-1dkpA:
undetectable		 1ereD-1dkpA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 11 LEU A 217
PRO A 173
PHE A 172
LEU A 170
PRO A  34
 None
 1.42A 1klmA-1dkpA:
0.0		 1klmA-1dkpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 10 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
 None
 1.26A 1pcgA-1dkpA:
undetectable		 1pcgA-1dkpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 10 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
 None
 1.26A 1qkuA-1dkpA:
0.0		 1qkuA-1dkpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 10 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
 None
 1.27A 1qkuB-1dkpA:
0.0		 1qkuB-1dkpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 10 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
 None
 1.26A 1qkuC-1dkpA:
0.0		 1qkuC-1dkpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 GLY A  59
GLY A 103
ILE A  55
ALA A  99
GLN A  64
 None
 1.04A 1ri4A-1dkpA:
undetectable		 1ri4A-1dkpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 10 LEU A 207
SER A 196
PHE A 155
THR A 156
ALA A 252
 None
 1.40A 1wygA-1dkpA:
undetectable		 1wygA-1dkpA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 8 TYR A 255
PHE A 254
THR A 156
PHE A 155
 None
IHP  A 550 (-4.4A)
None
None
 0.98A 1ykiA-1dkpA:
0.0
1ykiB-1dkpA:
0.0		 1ykiA-1dkpA:
20.74
1ykiB-1dkpA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 8 THR A 156
PHE A 155
TYR A 255
PHE A 254
 None
None
None
IHP  A 550 (-4.4A)
 0.98A 1ykiA-1dkpA:
0.0
1ykiB-1dkpA:
0.0		 1ykiA-1dkpA:
20.74
1ykiB-1dkpA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 8 TYR A 255
PHE A 254
THR A 156
PHE A 155
 None
IHP  A 550 (-4.4A)
None
None
 0.97A 1ykiC-1dkpA:
0.0
1ykiD-1dkpA:
0.0		 1ykiC-1dkpA:
20.74
1ykiD-1dkpA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 8 THR A 156
PHE A 155
TYR A 255
PHE A 254
 None
None
None
IHP  A 550 (-4.4A)
 0.98A 1ykiC-1dkpA:
0.0
1ykiD-1dkpA:
0.0		 1ykiC-1dkpA:
20.74
1ykiD-1dkpA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.12A 2aylA-1dkpA:
undetectable		 2aylA-1dkpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 LEU A 333
LEU A 307
GLY A 312
ALA A 313
ALA A 403
 None
 1.12A 2br4F-1dkpA:
undetectable		 2br4F-1dkpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 10 ALA A 313
LEU A 124
LEU A 310
ASN A 306
ARG A 267
 None
None
None
None
IHP  A 550 (-3.9A)
 1.39A 2ceoB-1dkpA:
0.0		 2ceoB-1dkpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 8 LEU A 366
PRO A 328
VAL A  19
GLY A  18
 None
 0.86A 2qd5A-1dkpA:
undetectable		 2qd5A-1dkpA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 8 LEU A 366
SER A  15
VAL A  19
GLY A  51
 None
 1.06A 2qd5A-1dkpA:
undetectable		 2qd5A-1dkpA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 8 LEU A 366
SER A  15
VAL A  19
GLY A  51
 None
 1.11A 2qd5B-1dkpA:
undetectable		 2qd5B-1dkpA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 11 LEU A 310
LEU A 314
ILE A 275
PHE A 396
LEU A 279
 None
 1.21A 2qeiA-1dkpA:
0.0		 2qeiA-1dkpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 8 LEU A 207
ILE A 152
LEU A 198
LEU A 257
 None
 0.74A 2xfhA-1dkpA:
0.0		 2xfhA-1dkpA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 ILE A 399
LEU A 310
GLN A 349
LEU A 279
VAL A 400
 None
 1.17A 3ix9B-1dkpA:
undetectable		 3ix9B-1dkpA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.00A 3kk6A-1dkpA:
undetectable		 3kk6A-1dkpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 5 GLN A 258
ILE A 144
LEU A 257
PHE A 254
 None
None
None
IHP  A 550 (-4.4A)
 1.16A 3ls4L-1dkpA:
undetectable		 3ls4L-1dkpA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 ILE A  13
VAL A  14
LEU A 333
ARG A 337
ILE A 399
 None
 0.94A 3mb5A-1dkpA:
undetectable		 3mb5A-1dkpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 11 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.01A 3pghB-1dkpA:
0.0		 3pghB-1dkpA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.01A 3pghC-1dkpA:
0.0		 3pghC-1dkpA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.02A 3pghD-1dkpA:
undetectable		 3pghD-1dkpA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 6 LEU A  58
TYR A  57
ALA A  99
LEU A 366
 None
 1.08A 3ravA-1dkpA:
undetectable		 3ravA-1dkpA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 6 LEU A  58
TYR A  57
ALA A  99
LEU A 366
 None
 1.09A 3rd0A-1dkpA:
undetectable		 3rd0A-1dkpA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 4 ASN A 251
SER A 206
LEU A 207
THR A 327
 None
None
None
HG  A 503 ( 3.7A)
 1.41A 4an2A-1dkpA:
0.3		 4an2A-1dkpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 6 ASN A 251
ASP A 304
GLY A 331
THR A 319
 None
IHP  A 550 (-3.2A)
None
None
 1.04A 4l1aB-1dkpA:
undetectable		 4l1aB-1dkpA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 9 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.12A 4rs0A-1dkpA:
0.0		 4rs0A-1dkpA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 ASP A  31
LEU A  28
LEU A 213
MET A 216
LEU A 170
 None
None
None
IHP  A 550 (-3.9A)
None
 1.12A 4x1fA-1dkpA:
0.0		 4x1fA-1dkpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 9 LEU A 333
ASP A 304
LEU A 310
LEU A 271
ALA A 268
 None
IHP  A 550 (-3.2A)
None
None
None
 1.11A 5dqfA-1dkpA:
undetectable		 5dqfA-1dkpA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.08A 5ikrB-1dkpA:
undetectable		 5ikrB-1dkpA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 12 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.14A 5jvzB-1dkpA:
0.0		 5jvzB-1dkpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWB_A_ACTA612_0
(TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 4 ASP A 273
LYS A 276
THR A 277
ASN A 401
 None
None
HG  A 501 ( 4.8A)
None
 1.05A 5jwbA-1dkpA:
0.0
5jwbH-1dkpA:
0.0		 5jwbA-1dkpA:
20.81
5jwbH-1dkpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 6 GLY A 373
PRO A 372
GLU A 374
SER A 351
 None
 1.13A 5ny7A-1dkpA:
undetectable		 5ny7A-1dkpA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 1dkp PHYTASE
(Escherichia
coli) 		5 / 11 PRO A 123
ILE A 300
ASP A 122
LEU A 293
THR A 277
 None
None
None
HG  A 501 (-4.9A)
HG  A 501 ( 4.8A)
 1.35A 5tiyA-1dkpA:
undetectable		 5tiyA-1dkpA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1dkp PHYTASE
(Escherichia
coli) 		4 / 5 LEU A  58
TYR A  61
ILE A 348
GLY A 373
 None
 1.07A 6hd6A-1dkpA:
undetectable		 6hd6A-1dkpA:
10.14