SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		4 / 4 ILE A  72
LEU A  75
VAL A  79
ALA A  87
 None
 0.62A 1mz9A-1dkrA:
undetectable		 1mz9A-1dkrA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		3 / 3 ILE A  72
LEU A  75
VAL A  79
 None
 0.23A 1mz9B-1dkrA:
undetectable		 1mz9B-1dkrA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		4 / 5 ILE A  72
LEU A  75
VAL A  79
ALA A  87
 None
 0.58A 1mz9C-1dkrA:
undetectable		 1mz9C-1dkrA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		3 / 3 LYS A  10
ILE A 302
THR A 127
 None
 0.85A 1rx3A-1dkrA:
2.3		 1rx3A-1dkrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ALA A 229
LEU A 256
LEU A 272
LEU A 156
THR A 233
 SO4  A1002 (-4.7A)
None
None
None
None
 1.15A 2oipB-1dkrA:
undetectable		 2oipB-1dkrA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ALA A 229
LEU A 256
LEU A 272
LEU A 156
THR A 233
 SO4  A1002 (-4.7A)
None
None
None
None
 1.13A 2oipC-1dkrA:
undetectable		 2oipC-1dkrA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 10 GLU A  74
GLY A  98
PHE A 117
LEU A 120
THR A 113
 None
 1.34A 3a3yA-1dkrA:
0.5		 3a3yA-1dkrA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ILE A 302
VAL A  28
GLU A  23
LEU A 297
VAL A  93
 None
 1.19A 3fpjB-1dkrA:
3.8		 3fpjB-1dkrA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 12 THR A 275
HIS A 253
LEU A 256
ILE A 286
LEU A 132
 None
 1.47A 3gwxB-1dkrA:
0.0		 3gwxB-1dkrA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ALA A 229
LEU A 256
LEU A 272
LEU A 156
THR A 233
 SO4  A1002 (-4.7A)
None
None
None
None
 1.15A 3hj3A-1dkrA:
2.0		 3hj3A-1dkrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ALA A 229
LEU A 256
LEU A 272
LEU A 156
THR A 233
 SO4  A1002 (-4.7A)
None
None
None
None
 1.10A 3hj3C-1dkrA:
undetectable		 3hj3C-1dkrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		3 / 3 LYS A  10
ILE A 302
THR A 127
 None
 0.88A 4gh8A-1dkrA:
2.4		 4gh8A-1dkrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		4 / 7 VAL A 274
ILE A 286
ILE A 264
ALA A 260
 None
 0.70A 4lv9A-1dkrA:
undetectable		 4lv9A-1dkrA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ALA A 229
LEU A 256
LEU A 272
LEU A 156
THR A 233
 SO4  A1002 (-4.7A)
None
None
None
None
 1.19A 4q0dC-1dkrA:
undetectable		 4q0dC-1dkrA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ALA A 229
LEU A 256
LEU A 272
LEU A 156
THR A 233
 SO4  A1002 (-4.7A)
None
None
None
None
 1.19A 4q0dD-1dkrA:
undetectable		 4q0dD-1dkrA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ALA A 301
LEU A 314
ILE A 155
GLY A 152
LEU A 132
 None
 1.00A 4xi3B-1dkrA:
undetectable		 4xi3B-1dkrA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		4 / 5 ILE A 222
GLY A 157
ILE A 170
LEU A 156
 None
 0.89A 5dzki-1dkrA:
0.1
5dzkj-1dkrA:
3.2
5dzkx-1dkrA:
undetectable		 5dzki-1dkrA:
21.91
5dzkj-1dkrA:
21.91
5dzkx-1dkrA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 8 VAL A  28
ILE A  24
ALA A  21
HIS A 306
VAL A  30
 None
 1.41A 5l94A-1dkrA:
0.0		 5l94A-1dkrA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 6 ILE A 195
MET A 208
ALA A 238
LEU A 239
ILE A 214
 None
 1.06A 5mvmB-1dkrA:
undetectable
5mvmC-1dkrA:
0.0		 5mvmB-1dkrA:
14.06
5mvmC-1dkrA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		5 / 8 VAL A 274
ILE A 264
LEU A 272
ILE A 286
SER A  65
 None
 1.31A 5numA-1dkrA:
0.0		 5numA-1dkrA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		3 / 3 ARG A  39
GLY A  43
GLU A  44
 None
 0.33A 6fgdA-1dkrA:
1.7		 6fgdA-1dkrA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE
(Bacillus
subtilis) 		3 / 3 LYS A 217
VAL A 169
ASP A 167
 None
 0.69A 6fgdA-1dkrA:
undetectable		 6fgdA-1dkrA:
24.57