SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 170
PHE A 530
GLY A 140
LEU A  80
PHE A 215
 None
 1.38A 1brpA-1dl2A:
undetectable		 1brpA-1dl2A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 349
LEU A 286
TYR A 297
GLY A 344
PHE A 442
 None
 1.06A 1fduC-1dl2A:
undetectable		 1fduC-1dl2A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 261
THR A 205
THR A 256
ILE A 181
 None
 0.83A 1gtnA-1dl2A:
undetectable
1gtnK-1dl2A:
undetectable		 1gtnA-1dl2A:
11.11
1gtnK-1dl2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 261
THR A 205
THR A 256
ILE A 181
 None
 0.82A 1gtnD-1dl2A:
undetectable
1gtnE-1dl2A:
undetectable		 1gtnD-1dl2A:
11.11
1gtnE-1dl2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 261
THR A 205
THR A 256
ILE A 181
 None
 0.85A 1gtnJ-1dl2A:
undetectable
1gtnK-1dl2A:
undetectable		 1gtnJ-1dl2A:
11.11
1gtnK-1dl2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 349
LEU A 286
TYR A 297
GLY A 344
PHE A 442
 None
 0.97A 1iolA-1dl2A:
undetectable		 1iolA-1dl2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 503
GLU A 526
ILE A 135
LEU A 338
 GOL  A 900 (-3.3A)
GOL  A 900 (-3.1A)
None
None
 1.48A 1q0yH-1dl2A:
0.0
1q0yL-1dl2A:
undetectable		 1q0yH-1dl2A:
15.78
1q0yL-1dl2A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 523
LEU A  93
PHE A 442
MET A 441
 None
 1.22A 1wrkB-1dl2A:
undetectable		 1wrkB-1dl2A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 523
LEU A  93
PHE A 442
MET A 441
 None
 1.20A 1wrlC-1dl2A:
undetectable		 1wrlC-1dl2A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		5 / 12 MET A 301
MET A 304
LEU A 308
ILE A 381
LEU A 345
 None
 1.23A 2j7xA-1dl2A:
0.0		 2j7xA-1dl2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 434
ILE A 459
ASN A 430
LEU A 396
 GOL  A 900 (-4.4A)
None
None
None
 1.28A 2wekB-1dl2A:
undetectable		 2wekB-1dl2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 269
GLU A 132
SER A 266
 None
GOL  A 900 ( 4.5A)
None
 0.72A 2xkkA-1dl2A:
undetectable
2xkkC-1dl2A:
0.0		 2xkkA-1dl2A:
22.15
2xkkC-1dl2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 273
GLU A 526
SER A 203
 None
GOL  A 900 (-3.1A)
None
 0.91A 2xkkA-1dl2A:
undetectable
2xkkC-1dl2A:
0.0		 2xkkA-1dl2A:
22.15
2xkkC-1dl2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 343
ALA A 347
THR A 351
ILE A 356
 None
 0.54A 3jusA-1dl2A:
0.6		 3jusA-1dl2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 343
ALA A 347
THR A 351
ILE A 356
 None
 0.54A 3jusA-1dl2A:
0.6		 3jusA-1dl2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 343
ALA A 347
THR A 351
ILE A 356
 None
 0.49A 3jusB-1dl2A:
0.3		 3jusB-1dl2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 431
GLU A 399
ARG A 433
HIS A 337
 None
None
GOL  A 900 ( 3.9A)
None
 1.35A 3ltwA-1dl2A:
0.0		 3ltwA-1dl2A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		6 / 12 VAL A  85
TYR A 159
LEU A 141
TYR A  53
TRP A  50
LEU A 120
 None
 1.32A 3n8wA-1dl2A:
0.0		 3n8wA-1dl2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  83
ASP A  86
PHE A 499
GLN A 432
 None
None
GOL  A 900 (-3.3A)
None
 0.76A 4ac9C-1dl2A:
undetectable		 4ac9C-1dl2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  83
ASP A  86
PHE A 499
GLN A 432
 None
None
GOL  A 900 (-3.3A)
None
 0.73A 4acaC-1dl2A:
undetectable		 4acaC-1dl2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  83
ASP A  86
PHE A 499
GLN A 432
 None
None
GOL  A 900 (-3.3A)
None
 0.77A 4acbC-1dl2A:
undetectable		 4acbC-1dl2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		5 / 12 MET A 301
MET A 304
LEU A 308
ILE A 381
LEU A 345
 None
 1.17A 4j24C-1dl2A:
0.0		 4j24C-1dl2A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		5 / 12 MET A 301
MET A 304
LEU A 308
ILE A 381
LEU A 345
 None
 1.19A 4j24D-1dl2A:
undetectable		 4j24D-1dl2A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		5 / 12 MET A 301
MET A 304
LEU A 308
ILE A 381
LEU A 345
 None
 1.19A 4j26A-1dl2A:
undetectable		 4j26A-1dl2A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		5 / 12 MET A 301
MET A 304
LEU A 308
ILE A 381
LEU A 345
 None
 1.19A 4j26B-1dl2A:
undetectable		 4j26B-1dl2A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1322_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 4 GLU A 290
THR A 545
GLU A 232
LYS A 216
 None
 1.28A 4mghA-1dl2A:
0.0		 4mghA-1dl2A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		5 / 8 LYS A 162
ALA A 163
GLY A 140
LEU A 142
LEU A 218
 None
 1.46A 4po0A-1dl2A:
2.4		 4po0A-1dl2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 279
TYR A 507
GLU A 503
 CA  A 901 ( 3.8A)
None
GOL  A 900 (-3.3A)
 0.78A 4ryaA-1dl2A:
undetectable		 4ryaA-1dl2A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  84
HIS A 528
LEU A 141
ALA A 144
 None
 0.99A 5hrqE-1dl2A:
undetectable
5hrqF-1dl2A:
undetectable
5hrqJ-1dl2A:
undetectable		 5hrqE-1dl2A:
3.69
5hrqF-1dl2A:
6.51
5hrqJ-1dl2A:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		3 / 3 THR A 179
THR A 205
LEU A 244
 None
 0.56A 5m66D-1dl2A:
undetectable		 5m66D-1dl2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		3 / 3 THR A 179
THR A 209
LEU A 244
 None
 0.69A 5m66D-1dl2A:
undetectable		 5m66D-1dl2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		5 / 12 MET A 301
MET A 304
LEU A 308
ILE A 381
LEU A 345
 None
 1.23A 5toaB-1dl2A:
undetectable		 5toaB-1dl2A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 237
THR A 260
THR A 179
PRO A 253
 None
 1.23A 5x2sI-1dl2A:
undetectable
5x2sJ-1dl2A:
undetectable
5x2sK-1dl2A:
undetectable		 5x2sI-1dl2A:
13.22
5x2sJ-1dl2A:
13.92
5x2sK-1dl2A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 6 MET A  92
GLU A 113
GLY A 140
GLY A 139
 None
 0.65A 5x7pB-1dl2A:
undetectable		 5x7pB-1dl2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 6 MET A  92
GLU A 113
TYR A 159
GLY A 139
 None
 0.96A 5x7pB-1dl2A:
undetectable		 5x7pB-1dl2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 273
ILE A 254
SER A 272
 None
 0.55A 5zw2A-1dl2A:
0.0		 5zw2A-1dl2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 181
THR A 179
THR A 209
LEU A 244
 None
 1.01A 6f3mD-1dl2A:
undetectable		 6f3mD-1dl2A:
21.75