SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 VAL A 128
PHE A 130
SER A 105
VAL A 103
 None
 0.93A 1e7cA-1dl5A:
0.0		 1e7cA-1dl5A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A  83
GLU A 107
ILE A 112
GLY A 135
THR A 151
 SAH  A 699 (-3.2A)
SAH  A 699 (-2.9A)
SAH  A 699 ( 4.5A)
SAH  A 699 (-3.5A)
SAH  A 699 (-3.2A)
 1.14A 1jg2A-1dl5A:
28.5		 1jg2A-1dl5A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 12 GLY A  83
GLY A  85
GLU A 107
ASP A 134
GLY A 135
THR A 151
 SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
SAH  A 699 (-3.5A)
SAH  A 699 (-3.2A)
 0.46A 1jg2A-1dl5A:
28.5		 1jg2A-1dl5A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 11 GLY A  83
GLY A  85
GLU A 107
ASP A 134
GLY A 135
THR A 151
 SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
SAH  A 699 (-3.5A)
SAH  A 699 (-3.2A)
 0.45A 1jg3A-1dl5A:
28.2		 1jg3A-1dl5A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 GLY A  83
GLY A  85
GLU A 107
GLY A 135
LEU A 212
 SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
SAH  A 699 (-4.0A)
 1.03A 1jg3A-1dl5A:
28.2		 1jg3A-1dl5A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 11 GLY A  83
GLY A  85
GLU A 107
ASP A 134
GLY A 135
THR A 151
 SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
SAH  A 699 (-3.5A)
SAH  A 699 (-3.2A)
 0.47A 1jg3B-1dl5A:
28.2		 1jg3B-1dl5A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 GLY A  83
GLY A  85
GLU A 107
GLY A 135
LEU A 212
 SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
SAH  A 699 (-4.0A)
 1.04A 1jg3B-1dl5A:
28.2		 1jg3B-1dl5A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 12 THR A  57
SER A  59
GLY A  85
ASN A  89
GLY A 135
THR A 151
 SAH  A 699 (-4.9A)
SAH  A 699 ( 3.9A)
SAH  A 699 (-3.5A)
SAH  A 699 (-4.9A)
SAH  A 699 (-3.5A)
SAH  A 699 (-3.2A)
 0.62A 1jg4A-1dl5A:
28.4		 1jg4A-1dl5A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLU A  81
GLY A  83
GLU A 107
ASP A 134
 SAH  A 699 (-3.4A)
SAH  A 699 (-3.2A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
 0.32A 1jg4A-1dl5A:
28.4		 1jg4A-1dl5A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A  83
GLY A  84
GLY A  85
GLU A 107
ASP A 134
 SAH  A 699 (-3.2A)
SAH  A 699 (-4.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
 0.67A 1qzzA-1dl5A:
8.9		 1qzzA-1dl5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 SER A  58
GLY A  87
ILE A 206
GLY A  84
GLY A  85
 SAH  A 699 ( 4.9A)
SAH  A 699 ( 4.8A)
SAH  A 699 ( 4.6A)
SAH  A 699 (-4.2A)
SAH  A 699 (-3.5A)
 0.90A 1uakA-1dl5A:
undetectable		 1uakA-1dl5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 PHE A 149
ALA A 185
LEU A  63
MET A  68
 None
 1.05A 1x8vA-1dl5A:
0.0		 1x8vA-1dl5A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A  83
GLY A  84
GLY A  85
GLU A 107
ASP A 134
 SAH  A 699 (-3.2A)
SAH  A 699 (-4.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
 0.72A 1xdsB-1dl5A:
6.9		 1xdsB-1dl5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A 212
ALA A 208
LEU A 215
ARG A 218
THR A 203
 SAH  A 699 (-4.0A)
SAH  A 699 (-3.6A)
None
None
None
 1.39A 2aa5A-1dl5A:
undetectable		 2aa5A-1dl5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 GLU A  81
GLY A  83
GLY A  85
GLU A 107
ASP A 134
 SAH  A 699 (-3.4A)
SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
 0.58A 3dxyA-1dl5A:
7.6		 3dxyA-1dl5A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 11 GLU A  81
GLY A  83
GLY A  85
GLU A 107
PHE A 205
 SAH  A 699 (-3.4A)
SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-2.9A)
None
 1.00A 3dxyA-1dl5A:
7.6		 3dxyA-1dl5A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 ARG A 273
ILE A 232
VAL A 267
THR A 257
 None
 1.19A 3eigA-1dl5A:
1.6		 3eigA-1dl5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 TYR A 108
TYR A 137
GLY A 210
 SAH  A 699 (-4.4A)
None
SAH  A 699 ( 4.4A)
 0.72A 3eteB-1dl5A:
undetectable
3eteD-1dl5A:
3.1
3eteF-1dl5A:
3.0		 3eteB-1dl5A:
21.86
3eteD-1dl5A:
21.86
3eteF-1dl5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A  82
GLY A  83
VAL A 106
ILE A 112
VAL A 154
 None
SAH  A 699 (-3.2A)
SAH  A 699 (-4.7A)
SAH  A 699 ( 4.5A)
None
 1.00A 3fpjA-1dl5A:
9.5		 3fpjA-1dl5A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 ASP A 146
GLY A 169
LYS A 166
GLU A 167
 None
 1.23A 3hznD-1dl5A:
0.0		 3hznD-1dl5A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ASN A 119
PHE A 149
PRO A 174
GLY A  83
ILE A 112
 None
None
None
SAH  A 699 (-3.2A)
SAH  A 699 ( 4.5A)
 1.08A 3iv6A-1dl5A:
7.8		 3iv6A-1dl5A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 LEU A 247
THR A 248
GLY A 262
ALA A 280
 None
 0.79A 3jusB-1dl5A:
0.0		 3jusB-1dl5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 6 SER A  59
PHE A 205
PHE A 149
ASN A  89
 SAH  A 699 ( 3.9A)
None
None
SAH  A 699 (-4.9A)
 1.09A 3lskB-1dl5A:
2.0		 3lskB-1dl5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 6 SER A  59
PHE A 205
PHE A 149
ASN A  89
 SAH  A 699 ( 3.9A)
None
None
SAH  A 699 (-4.9A)
 1.02A 3lskD-1dl5A:
2.0		 3lskD-1dl5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLU A  81
GLY A  83
GLY A  85
ASN A  89
ASP A 134
 SAH  A 699 (-3.4A)
SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-4.9A)
SAH  A 699 (-3.5A)
 0.78A 3sglA-1dl5A:
6.7		 3sglA-1dl5A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLU A  81
GLY A  83
GLY A  85
THR A  86
ASP A 134
 SAH  A 699 (-3.4A)
SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
None
SAH  A 699 (-3.5A)
 0.63A 3sglA-1dl5A:
6.7		 3sglA-1dl5A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 VAL A 128
PHE A 130
PHE A  30
ILE A  25
 None
 0.97A 3zjqA-1dl5A:
0.0		 3zjqA-1dl5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 VAL A 128
PHE A 130
PHE A  30
ILE A  25
 None
 0.98A 3zjqB-1dl5A:
0.0		 3zjqB-1dl5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A  83
GLY A  84
GLY A  85
SER A 109
VAL A 152
 SAH  A 699 (-3.2A)
SAH  A 699 (-4.2A)
SAH  A 699 (-3.5A)
None
SAH  A 699 (-4.1A)
 0.55A 4htfA-1dl5A:
8.8		 4htfA-1dl5A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 12 GLY A  83
GLY A  84
GLY A  85
SER A 109
VAL A 152
VAL A 154
 SAH  A 699 (-3.2A)
SAH  A 699 (-4.2A)
SAH  A 699 (-3.5A)
None
SAH  A 699 (-4.1A)
None
 1.11A 4htfB-1dl5A:
9.9		 4htfB-1dl5A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A 122
GLU A  29
ASN A 119
 None
 0.86A 4imaD-1dl5A:
3.4		 4imaD-1dl5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A 122
GLU A  29
ASN A 119
 None
 0.86A 4ip7D-1dl5A:
3.3		 4ip7D-1dl5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 120
LEU A 102
ILE A 125
ILE A  25
ALA A  21
 None
 0.96A 4ltwA-1dl5A:
undetectable		 4ltwA-1dl5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 7 VAL A 154
ASN A 176
ILE A 175
PHE A 186
ILE A  82
 None
 1.33A 5bmvC-1dl5A:
undetectable		 5bmvC-1dl5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 7 VAL A 154
ASN A 176
PHE A 186
VAL A 173
ILE A  82
 None
 1.40A 5bmvC-1dl5A:
undetectable		 5bmvC-1dl5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLY A  83
GLY A  85
GLU A 107
ASP A 134
 SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
SAH  A 699 (-2.9A)
SAH  A 699 (-3.5A)
 0.71A 5ergB-1dl5A:
11.5		 5ergB-1dl5A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 6 SER A 314
GLY A 197
ASN A 198
MET A 302
 None
 1.14A 5j4nA-1dl5A:
0.0		 5j4nA-1dl5A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 SER A  59
GLY A  83
GLY A  85
SER A 109
ASP A 134
 SAH  A 699 ( 3.9A)
SAH  A 699 (-3.2A)
SAH  A 699 (-3.5A)
None
SAH  A 699 (-3.5A)
 1.09A 5kpcB-1dl5A:
7.7		 5kpcB-1dl5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLU A 107
VAL A 106
GLY A 209
LEU A 212
 SAH  A 699 (-2.9A)
SAH  A 699 (-4.7A)
SAH  A 699 (-3.9A)
SAH  A 699 (-4.0A)
 0.99A 5sxqA-1dl5A:
0.0		 5sxqA-1dl5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLU A 107
VAL A 106
GLY A 209
LEU A 212
 SAH  A 699 (-2.9A)
SAH  A 699 (-4.7A)
SAH  A 699 (-3.9A)
SAH  A 699 (-4.0A)
 1.00A 5sxqB-1dl5A:
undetectable		 5sxqB-1dl5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLU A 107
VAL A 106
GLY A 209
LEU A 212
 SAH  A 699 (-2.9A)
SAH  A 699 (-4.7A)
SAH  A 699 (-3.9A)
SAH  A 699 (-4.0A)
 0.97A 5sxtA-1dl5A:
0.0		 5sxtA-1dl5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLU A 107
VAL A 106
GLY A 209
LEU A 212
 SAH  A 699 (-2.9A)
SAH  A 699 (-4.7A)
SAH  A 699 (-3.9A)
SAH  A 699 (-4.0A)
 0.99A 5sxtB-1dl5A:
0.0		 5sxtB-1dl5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLU A 107
VAL A 106
GLY A 209
LEU A 212
 SAH  A 699 (-2.9A)
SAH  A 699 (-4.7A)
SAH  A 699 (-3.9A)
SAH  A 699 (-4.0A)
 1.00A 5syjA-1dl5A:
undetectable		 5syjA-1dl5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLU A 107
VAL A 106
GLY A 209
LEU A 212
 SAH  A 699 (-2.9A)
SAH  A 699 (-4.7A)
SAH  A 699 (-3.9A)
SAH  A 699 (-4.0A)
 0.98A 5syjB-1dl5A:
undetectable		 5syjB-1dl5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A 135
TYR A 136
LEU A  80
VAL A 150
 SAH  A 699 (-3.5A)
None
None
None
 0.71A 5x80A-1dl5A:
0.0
5x80B-1dl5A:
0.0		 5x80A-1dl5A:
17.67
5x80B-1dl5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 VAL A 147
PRO A 184
LEU A 177
PHE A  67
 None
 1.19A 6aycA-1dl5A:
undetectable		 6aycA-1dl5A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 GLY A  83
THR A 151
SER A  58
SER A  59
 SAH  A 699 (-3.2A)
SAH  A 699 (-3.2A)
SAH  A 699 ( 4.9A)
SAH  A 699 ( 3.9A)
 1.11A 6jmjA-1dl5A:
2.7		 6jmjA-1dl5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A  83
THR A 151
SER A  58
SER A  59
 SAH  A 699 (-3.2A)
SAH  A 699 (-3.2A)
SAH  A 699 ( 4.9A)
SAH  A 699 ( 3.9A)
 1.10A 6jogA-1dl5A:
3.0		 6jogA-1dl5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 THR A 207
GLU A 202
ASN A 176
 None
 0.87A 6nj9K-1dl5A:
9.6		 6nj9K-1dl5A:
23.16