SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
3 / 3 GLU A 298
LYS A 496
VAL A 498
None
0.97A 1l2iA-1dlcA:
1.1
1l2iA-1dlcA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
5 / 12 VAL A 295
LEU A 290
GLU A 639
HIS A 566
TYR A 601
None
1.43A 1mmkA-1dlcA:
undetectable
1mmkA-1dlcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 7 PHE A 640
SER A 610
PHE A 584
LEU A 514
None
0.95A 1qcaA-1dlcA:
0.0
1qcaA-1dlcA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
5 / 9 TYR A 291
THR A 297
GLY A 534
THR A 533
ALA A 281
None
1.31A 2cojA-1dlcA:
undetectable
2cojB-1dlcA:
undetectable
2cojA-1dlcA:
22.09
2cojB-1dlcA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
5 / 9 VAL A  80
THR A 297
GLY A 534
THR A 533
ALA A 281
None
1.39A 2cojA-1dlcA:
undetectable
2cojB-1dlcA:
undetectable
2cojA-1dlcA:
22.09
2cojB-1dlcA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 TYR A 268
ARG A 269
MET A 272
THR A 273
None
1.21A 2eimJ-1dlcA:
0.0
2eimJ-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 TYR A 268
ARG A 269
MET A 272
THR A 273
None
1.18A 2eimW-1dlcA:
0.0
2eimW-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 7 TYR A 268
ASN A 248
TRP A 246
LEU A 194
None
1.10A 2hzqA-1dlcA:
0.0
2hzqA-1dlcA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
5 / 11 ALA A 517
ILE A 622
ILE A 538
ALA A 524
ALA A 546
None
1.07A 2qhfA-1dlcA:
0.0
2qhfA-1dlcA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
5 / 10 TYR A 214
ILE A 213
PHE A 206
LEU A 147
VAL A 144
None
1.37A 2w98A-1dlcA:
undetectable
2w98A-1dlcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 TYR A 268
ARG A 269
MET A 272
THR A 273
None
1.32A 3abkN-1dlcA:
1.2
3abkW-1dlcA:
0.0
3abkN-1dlcA:
20.97
3abkW-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 TYR A 268
ARG A 269
MET A 272
THR A 273
None
1.29A 3ag1J-1dlcA:
0.0
3ag1J-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 TYR A 268
ARG A 269
MET A 272
THR A 273
None
1.25A 3ag2J-1dlcA:
0.0
3ag2J-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 TYR A 268
ARG A 269
MET A 272
THR A 273
None
1.32A 3ag4J-1dlcA:
0.0
3ag4J-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 7 VAL A 140
VAL A 144
LEU A 147
SER A 148
None
0.90A 3hs6B-1dlcA:
0.0
3hs6B-1dlcA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 8 PHE A 424
ALA A 402
ALA A 404
THR A 406
None
0.98A 3l4dA-1dlcA:
undetectable
3l4dA-1dlcA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
5 / 10 LEU A 333
GLY A 623
ILE A 622
VAL A 526
LEU A 520
None
1.04A 3ogpA-1dlcA:
0.0
3ogpA-1dlcA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
5 / 12 ILE A 635
ASP A 636
PHE A 589
TYR A 291
ILE A 509
None
1.10A 3pwwA-1dlcA:
undetectable
3pwwA-1dlcA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
3 / 3 LYS A  63
ILE A  70
THR A 195
None
0.88A 4gh8A-1dlcA:
0.0
4gh8A-1dlcA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
3 / 3 MET A 477
MET A 481
TYR A 327
None
1.21A 4p6xI-1dlcA:
1.2
4p6xI-1dlcA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 ILE A 573
VAL A 633
ILE A 635
VAL A 624
None
0.74A 4xdtA-1dlcA:
0.0
4xdtA-1dlcA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
3 / 3 ASN A 618
LEU A 512
PHE A 501
None
0.80A 5dsgA-1dlcA:
2.9
5dsgA-1dlcA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 GLU A 639
THR A 510
GLU A 298
LEU A 282
None
1.16A 5hm8A-1dlcA:
undetectable
5hm8A-1dlcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 GLU A 639
THR A 510
GLU A 298
LEU A 282
None
1.15A 5hm8B-1dlcA:
undetectable
5hm8B-1dlcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 GLU A 639
THR A 510
GLU A 298
LEU A 282
None
1.15A 5hm8C-1dlcA:
undetectable
5hm8C-1dlcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 GLU A 639
THR A 510
GLU A 298
LEU A 282
None
1.16A 5hm8D-1dlcA:
undetectable
5hm8D-1dlcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 GLU A 639
THR A 510
GLU A 298
LEU A 282
None
1.15A 5hm8E-1dlcA:
undetectable
5hm8E-1dlcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 GLU A 639
THR A 510
GLU A 298
LEU A 282
None
1.15A 5hm8F-1dlcA:
undetectable
5hm8F-1dlcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 GLU A 639
THR A 510
GLU A 298
LEU A 282
None
1.25A 5hm8G-1dlcA:
undetectable
5hm8G-1dlcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 GLU A 639
THR A 510
GLU A 298
LEU A 282
None
1.15A 5hm8H-1dlcA:
undetectable
5hm8H-1dlcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
5 / 11 ILE A 622
GLN A 586
PHE A 575
LEU A 577
CYH A 540
None
1.23A 5ji0A-1dlcA:
undetectable
5ji0A-1dlcA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 6 GLU A 174
ARG A 231
LEU A 235
ARG A 178
None
1.17A 5l6eA-1dlcA:
undetectable
5l6eB-1dlcA:
0.0
5l6eA-1dlcA:
16.61
5l6eB-1dlcA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
3 / 3 ASN A 383
TYR A 358
CYH A 478
None
0.86A 5lsuB-1dlcA:
undetectable
5lsuB-1dlcA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 7 LEU A 299
GLY A 535
THR A 533
ALA A 281
None
0.65A 5o96C-1dlcA:
undetectable
5o96C-1dlcA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
3 / 3 GLY A 318
THR A 492
PRO A 307
None
0.59A 5v5zA-1dlcA:
0.8
5v5zA-1dlcA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
5 / 12 ALA A 198
LEU A 205
VAL A  72
TYR A  92
PHE A  95
None
1.29A 5vlmH-1dlcA:
1.1
5vlmH-1dlcA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 TYR A 268
ARG A 269
MET A 272
THR A 273
None
1.12A 5w97J-1dlcA:
0.0
5w97J-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 TYR A 268
ARG A 269
MET A 272
THR A 273
None
1.19A 5wauJ-1dlcA:
0.0
5wauJ-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 TYR A 268
ARG A 269
MET A 272
THR A 273
None
1.22A 5x1fW-1dlcA:
0.0
5x1fW-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 7 TYR A 268
ARG A 269
MET A 272
THR A 273
None
0.92A 5xdqA-1dlcA:
1.9
5xdqJ-1dlcA:
0.0
5xdqA-1dlcA:
20.97
5xdqJ-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_2
(-)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 4 GLN A 232
THR A 236
HIS A 566
LEU A 606
None
1.43A 6f3nB-1dlcA:
undetectable
6f3nB-1dlcA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis)
4 / 5 TYR A 268
ARG A 269
MET A 272
THR A 273
None
1.41A 6nknJ-1dlcA:
undetectable
6nknJ-1dlcA:
7.37