SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 7 GLY A 216
ASP A 102
HIS A  57
ALA A  55
 None
 0.99A 1gxsA-1dleA:
undetectable
1gxsB-1dleA:
0.0		 1gxsA-1dleA:
18.83
1gxsB-1dleA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 GLN A  30
ILE A  33
ALA A  31
VAL A  52
VAL A 212
 None
 0.97A 1n4hA-1dleA:
0.0		 1n4hA-1dleA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 GLN A  30
ILE A  33
ALA A  31
VAL A 212
ALA A 104
 None
 1.02A 1n4hA-1dleA:
0.0		 1n4hA-1dleA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 TRP A 237
VAL A  66
ARG A  81
 None
 0.87A 3b0wA-1dleA:
0.0		 3b0wA-1dleA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
 1.10A 3eluA-1dleA:
undetectable		 3eluA-1dleA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 GLU A  49
TYR A 114
SER A   1
 None
 0.89A 4at0A-1dleA:
0.0		 4at0A-1dleA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 VAL A  66
ILE A  33
GLY A 196
ASP A 102
ILE A 106
 None
 0.85A 4q5mA-1dleA:
undetectable		 4q5mA-1dleA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 VAL A  47
LEU A 181
VAL A 212
GLY A 211
LEU A 123
 None
 0.96A 5iktA-1dleA:
0.0		 5iktA-1dleA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 VAL A  66
GLY A  44
ALA A  31
LEU A 112
LEU A 108
 None
 1.08A 5x23A-1dleA:
0.0		 5x23A-1dleA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 VAL A  66
GLY A  44
ALA A  31
LEU A 112
LEU A 108
 None
 1.09A 5xxiA-1dleA:
undetectable		 5xxiA-1dleA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1dle COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
 None
 0.82A 6c2mC-1dleA:
4.1		 6c2mC-1dleA:
14.39