SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dm0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		5 / 9 PHE A  92
TYR A 114
ALA A 166
GLU A 167
ARG A 170
 None
 0.57A 1mrgA-1dm0A:
22.4		 1mrgA-1dm0A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		5 / 9 TYR A  77
PHE A  95
ALA A 166
GLU A 167
ARG A 170
 None
 1.28A 1mrgA-1dm0A:
22.4		 1mrgA-1dm0A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		5 / 12 THR A  36
GLY A 234
ILE A 174
PHE A 171
ALA A 166
 None
 1.34A 1oltA-1dm0A:
undetectable		 1oltA-1dm0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		3 / 3 ASN A 202
ILE A 174
MET A 192
 None
 0.69A 2h42C-1dm0A:
undetectable		 2h42C-1dm0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		5 / 12 ILE A  20
ASN A  48
ARG A 170
LEU A 169
ALA A 166
 None
 1.06A 3dzyA-1dm0A:
undetectable		 3dzyA-1dm0A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		4 / 8 ALA A 194
VAL A 197
ASP A 198
LEU A 201
 None
 0.74A 3roxA-1dm0A:
undetectable		 3roxA-1dm0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		4 / 5 ILE A  57
THR A 137
SER A 138
PHE A 161
 None
 1.11A 3snfA-1dm0A:
0.0		 3snfA-1dm0A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		4 / 5 VAL A  82
ILE A  70
LEU A  69
ARG A  68
 None
 0.75A 4mghA-1dm0A:
0.0		 4mghA-1dm0A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		3 / 3 GLU A 167
ALA A 168
PHE A 171
 None
 0.59A 4v1fA-1dm0A:
0.0		 4v1fA-1dm0A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		3 / 3 GLU A 167
ALA A 168
PHE A 171
 None
 0.56A 4v1fC-1dm0A:
0.0		 4v1fC-1dm0A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		5 / 9 PHE A  92
TYR A 114
ALA A 166
GLU A 167
ARG A 170
 None
 0.55A 4yp2B-1dm0A:
22.1		 4yp2B-1dm0A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		5 / 9 PHE A  92
TYR A 114
ALA A 166
GLU A 167
ARG A 170
 None
 0.54A 5cf9B-1dm0A:
22.2		 5cf9B-1dm0A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		3 / 3 MET A 128
GLU A 167
ARG A 125
 None
 1.09A 5tjyA-1dm0A:
undetectable		 5tjyA-1dm0A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		5 / 12 PHE A  95
PHE A  50
LEU A 238
PHE A 257
ALA A 168
 None
 1.05A 5vc0A-1dm0A:
undetectable		 5vc0A-1dm0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		4 / 6 VAL A  78
TYR A 114
GLU A 167
ARG A 170
 None
 0.50A 5z3jA-1dm0A:
23.1		 5z3jA-1dm0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 1dm0 SHIGA TOXIN A
SUBUNIT
(Shigella
dysenteriae) 		3 / 3 SER A 279
SER A 280
ALA A 263
 None
 0.67A 6dwnC-1dm0A:
0.0		 6dwnC-1dm0A:
15.36