SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dm3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		4 / 6 ALA A 299
SER A 353
LEU A 300
TRP A 305
 None
 0.84A 1gahA-1dm3A:
undetectable		 1gahA-1dm3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 VAL A  76
GLY A  75
ASN A  65
ALA A  67
ILE A  53
 None
 1.12A 1kxhA-1dm3A:
undetectable		 1kxhA-1dm3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 ILE A 379
GLY A  90
GLY A 354
ILE A 350
ALA A  95
 SCY  A  89 ( 4.6A)
SCY  A  89 ( 2.4A)
SCY  A  89 ( 4.6A)
SCY  A  89 ( 4.5A)
None
 1.03A 1nv8B-1dm3A:
undetectable		 1nv8B-1dm3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		6 / 12 LEU A 377
THR A 376
ALA A 375
LEU A 361
ILE A 346
GLY A 342
 SCY  A  89 ( 3.8A)
None
None
None
None
None
 1.50A 1qknA-1dm3A:
undetectable		 1qknA-1dm3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 10 ALA A 256
LEU A 258
MET A 259
ILE A 269
LEU A 272
 None
 1.37A 1qkuA-1dm3A:
undetectable		 1qkuA-1dm3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 10 ALA A 256
LEU A 258
MET A 259
ILE A 269
LEU A 272
 None
 1.39A 1qkuB-1dm3A:
undetectable		 1qkuB-1dm3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 10 ALA A 256
LEU A 258
MET A 259
ILE A 269
LEU A 272
 None
 1.37A 1qkuC-1dm3A:
undetectable		 1qkuC-1dm3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 ILE A 379
GLY A  90
GLY A 354
ILE A 350
ALA A  95
 SCY  A  89 ( 4.6A)
SCY  A  89 ( 2.4A)
SCY  A  89 ( 4.6A)
SCY  A  89 ( 4.5A)
None
 0.98A 1sg9B-1dm3A:
undetectable		 1sg9B-1dm3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 10 LEU A 258
ALA A   8
ILE A   7
VAL A  38
ALA A  37
 None
None
None
None
SO4  A 811 ( 4.0A)
 1.08A 1xp0A-1dm3A:
0.0		 1xp0A-1dm3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 11 ARG A 267
ALA A  42
GLU A  48
LEU A 258
VAL A 112
 None
 0.96A 2bxeB-1dm3A:
0.0		 2bxeB-1dm3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		4 / 8 ARG A 267
ALA A  42
GLU A  48
LEU A 258
 None
 0.88A 2bxgA-1dm3A:
0.0		 2bxgA-1dm3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 GLY A  90
GLY A 354
GLY A 114
ILE A 379
VAL A 385
 SCY  A  89 ( 2.4A)
SCY  A  89 ( 4.6A)
None
SCY  A  89 ( 4.6A)
None
 0.96A 2oxtC-1dm3A:
undetectable		 2oxtC-1dm3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 9 ALA A 246
ALA A 320
GLY A 289
SER A 247
ALA A 318
 ACO  A 813 ( 4.1A)
None
None
ACO  A 813 (-3.7A)
ACO  A 813 (-3.0A)
 1.45A 2vh3A-1dm3A:
0.0		 2vh3A-1dm3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		4 / 5 ARG A  12
ASP A 216
ILE A 219
GLU A 198
 None
 0.95A 2xrzA-1dm3A:
0.0
2xrzB-1dm3A:
0.2		 2xrzA-1dm3A:
21.60
2xrzB-1dm3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		3 / 3 SER A 120
GLY A  20
GLY A  16
 None
 0.47A 3bogA-1dm3A:
0.0
3bogC-1dm3A:
0.0		 3bogA-1dm3A:
undetectable
3bogC-1dm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 11 ALA A 113
ILE A  35
VAL A  38
VAL A  34
GLY A  31
 None
 0.92A 3kw4A-1dm3A:
0.1		 3kw4A-1dm3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 LEU A 258
ILE A 269
GLY A 273
ILE A 275
LEU A 358
 None
 1.04A 3uj6A-1dm3A:
undetectable		 3uj6A-1dm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 LEU A 258
ILE A 269
GLY A 273
ILE A 275
LEU A 358
 None
 1.04A 3uj7B-1dm3A:
undetectable		 3uj7B-1dm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 LEU A 300
ALA A 386
ILE A 307
LEU A 310
VAL A 313
 None
 0.96A 4nkvB-1dm3A:
undetectable		 4nkvB-1dm3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 GLU A 198
ALA A 375
ALA A 355
GLY A 354
LEU A  93
 None
None
None
SCY  A  89 ( 4.6A)
None
 1.03A 4oaeA-1dm3A:
undetectable		 4oaeA-1dm3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 9 ALA A 256
VAL A 385
GLY A  92
ALA A 355
ILE A   7
 None
 1.10A 4r21B-1dm3A:
undetectable		 4r21B-1dm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		4 / 7 ALA A 104
SER A   4
ILE A 275
LEU A 258
 None
 1.00A 4uymA-1dm3A:
0.0		 4uymA-1dm3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 9 LEU A 377
PHE A 319
ALA A 343
SER A 247
ALA A 246
 SCY  A  89 ( 3.8A)
ACO  A 813 (-4.4A)
None
ACO  A 813 (-3.7A)
ACO  A 813 ( 4.1A)
 1.39A 4wnuB-1dm3A:
0.0		 4wnuB-1dm3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 ALA A 256
VAL A  96
VAL A  15
GLU A 314
ASN A 316
 None
 1.41A 4zj8A-1dm3A:
undetectable		 4zj8A-1dm3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 8 ALA A 255
VAL A 112
GLY A 115
ALA A 253
GLY A  31
 None
 1.24A 4zjzB-1dm3A:
undetectable		 4zjzB-1dm3A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 ALA A 375
LEU A 362
LEU A 361
MET A 100
LEU A  93
 None
 1.21A 4zn7A-1dm3A:
0.0		 4zn7A-1dm3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 ALA A 253
GLY A  55
GLY A 115
GLY A 354
ALA A  67
 None
None
None
SCY  A  89 ( 4.6A)
None
 1.01A 5c0oE-1dm3A:
undetectable		 5c0oE-1dm3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		4 / 5 PRO A 292
VAL A 326
GLY A 308
VAL A 313
 None
 1.02A 6ak3B-1dm3A:
0.0		 6ak3B-1dm3A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 9 ALA A   8
VAL A  38
ALA A  10
SER A   9
VAL A 112
 None
 1.24A 6bklA-1dm3A:
undetectable
6bklB-1dm3A:
undetectable
6bklC-1dm3A:
undetectable
6bklD-1dm3A:
undetectable		 6bklA-1dm3A:
5.29
6bklB-1dm3A:
5.29
6bklC-1dm3A:
5.29
6bklD-1dm3A:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		4 / 6 GLN A  56
LEU A  30
ARG A  12
PRO A 349
 None
 1.33A 6brdB-1dm3A:
0.0		 6brdB-1dm3A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 10 ALA A 256
LEU A 258
MET A 259
ILE A 269
LEU A 272
 None
 1.42A 6cbzB-1dm3A:
undetectable		 6cbzB-1dm3A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 10 SER A 296
LEU A 358
LEU A 377
ILE A 389
GLY A 373
 None
None
SCY  A  89 ( 3.8A)
None
None
 1.27A 6dm0B-1dm3A:
undetectable
6dm0C-1dm3A:
undetectable		 6dm0B-1dm3A:
12.34
6dm0C-1dm3A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89
(Zoogloea
ramigera) 		5 / 12 GLY A 341
VAL A 337
GLY A  16
ASN A 316
ASN A 327
 None
 1.12A 6gngA-1dm3A:
undetectable		 6gngA-1dm3A:
22.50