SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		5 / 9 LEU A 288
LEU A 189
VAL A 283
GLY A 284
ALA A 303
 None
 1.31A 1e7aA-1dmlA:
undetectable		 1e7aA-1dmlA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 5 SER A 211
THR A 220
GLU A 203
GLY A 205
 None
 1.01A 1icrA-1dmlA:
0.0
1icrB-1dmlA:
0.0		 1icrA-1dmlA:
21.23
1icrB-1dmlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 6 SER A 211
THR A 220
GLU A 203
GLY A 205
 None
 0.96A 1icuA-1dmlA:
0.1
1icuB-1dmlA:
0.1		 1icuA-1dmlA:
21.23
1icuB-1dmlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 6 GLU A 203
GLY A 205
SER A 211
THR A 220
 None
 0.97A 1icuA-1dmlA:
0.0
1icuB-1dmlA:
0.0		 1icuA-1dmlA:
21.23
1icuB-1dmlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 6 SER A 211
THR A 220
GLU A 203
GLY A 205
 None
 0.99A 1icuC-1dmlA:
0.0
1icuD-1dmlA:
0.0		 1icuC-1dmlA:
21.23
1icuD-1dmlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 5 SER A 211
THR A 220
GLU A 203
GLY A 205
 None
 0.99A 1icvC-1dmlA:
0.1
1icvD-1dmlA:
0.0		 1icvC-1dmlA:
21.23
1icvD-1dmlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 5 GLU A 203
GLY A 205
SER A 211
THR A 220
 None
 0.97A 1icvC-1dmlA:
0.0
1icvD-1dmlA:
0.0		 1icvC-1dmlA:
21.23
1icvD-1dmlA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 6 SER A 211
THR A 220
GLU A 203
GLY A 205
 None
 0.97A 1kqbA-1dmlA:
0.0
1kqbB-1dmlA:
0.0		 1kqbA-1dmlA:
21.41
1kqbB-1dmlA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 5 GLU A 203
GLY A 205
SER A 211
THR A 220
 None
 0.95A 1kqbA-1dmlA:
0.0
1kqbB-1dmlA:
0.0		 1kqbA-1dmlA:
21.41
1kqbB-1dmlA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 6 GLU A 203
GLY A 205
SER A 211
THR A 220
 None
 0.97A 1kqbC-1dmlA:
0.0
1kqbD-1dmlA:
0.0		 1kqbC-1dmlA:
21.41
1kqbD-1dmlA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 8 LEU A 189
VAL A 269
LEU A 299
VAL A 283
 None
 0.90A 2bdmA-1dmlA:
0.0		 2bdmA-1dmlA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 7 PHE A 290
VAL A 188
THR A 192
VAL A 269
 None
 0.90A 2zaxA-1dmlA:
undetectable		 2zaxA-1dmlA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
DNA POLYMERASE
(Human
alphaherpesvirus
1;
Human
alphaherpesvirus
1) 		6 / 12 GLY B1215
GLY B1217
VAL A 167
ALA B1220
THR B1223
LEU B1227
 None
 1.29A 3dh0B-1dmlB:
undetectable		 3dh0B-1dmlB:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 7 LEU A 185
VAL A 188
THR A 192
VAL A 269
 None
 1.02A 3fwgB-1dmlA:
undetectable		 3fwgB-1dmlA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 7 PHE A 290
VAL A 188
THR A 192
VAL A 269
 None
 0.93A 3fwgB-1dmlA:
undetectable		 3fwgB-1dmlA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 7 PHE A 290
VAL A 188
THR A 192
VAL A 269
 None
 0.94A 3fwiA-1dmlA:
undetectable		 3fwiA-1dmlA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1dml DNA POLYMERASE
DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		5 / 11 VAL A 167
LEU A 168
LEU A  58
GLY B1217
ALA B1216
 None
 1.24A 3pghB-1dmlA:
0.0		 3pghB-1dmlA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		5 / 10 GLN A 184
VAL A 256
PHE A 210
LEU A 288
THR A 287
 None
 1.45A 3zncA-1dmlA:
undetectable		 3zncA-1dmlA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		5 / 9 ILE A  72
GLN A 282
LEU A 281
VAL A 309
LEU A  54
 None
 1.17A 4g1bC-1dmlA:
undetectable		 4g1bC-1dmlA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 8 ALA A 303
THR A 192
VAL A 212
PHE A 202
 None
 1.04A 4ltwA-1dmlA:
undetectable		 4ltwA-1dmlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 6 LEU A 109
MET A  61
LEU A 125
ILE A 140
 None
 1.07A 4okxA-1dmlA:
undetectable		 4okxA-1dmlA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 5 PHE A 202
PHE A 221
PHE A 210
VAL A 188
 None
 1.01A 5a1rA-1dmlA:
0.0		 5a1rA-1dmlA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		5 / 8 ALA A 311
LEU A 185
LEU A 189
LEU A 299
LEU A 288
 None
 1.18A 5jqbA-1dmlA:
0.0
5jqbB-1dmlA:
0.0		 5jqbA-1dmlA:
22.58
5jqbB-1dmlA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		3 / 3 VAL A 212
VAL A 219
GLN A 184
 None
 0.71A 5qglA-1dmlA:
0.8		 5qglA-1dmlA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
DNA POLYMERASE
(Human
alphaherpesvirus
1;
Human
alphaherpesvirus
1) 		5 / 12 LEU B1234
THR B1233
GLY A 172
PHE A 165
VAL A 167
 None
 1.03A 5tuiB-1dmlB:
undetectable		 5tuiB-1dmlB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		5 / 8 GLY A  42
LEU A  44
LEU A 108
VAL A 111
GLY A  37
 None
 1.13A 5vkqB-1dmlA:
0.0
5vkqC-1dmlA:
undetectable		 5vkqB-1dmlA:
12.05
5vkqC-1dmlA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1dml DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
alphaherpesvirus
1) 		4 / 6 LYS A 316
LEU A 315
PHE A 313
PHE A 265
 None
 1.12A 5w97C-1dmlA:
undetectable
5w97J-1dmlA:
0.0		 5w97C-1dmlA:
22.39
5w97J-1dmlA:
10.03