SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		5 / 7 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
 0.68A 1j8uA-1dmwA:
55.0		 1j8uA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		6 / 7 VAL A 245
LEU A 249
SER A 251
PHE A 254
LEU A 255
ALA A 322
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
HBI  A 700 (-3.6A)
 0.13A 1j8uA-1dmwA:
55.0		 1j8uA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		9 / 12 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
HIS A 290
TYR A 325
GLU A 330
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 1.05A 1kw0A-1dmwA:
42.7		 1kw0A-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		9 / 12 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
HIS A 290
TYR A 325
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.98A 1kw0A-1dmwA:
42.7		 1kw0A-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		9 / 12 VAL A 245
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
TRP A 326
GLU A 330
 None
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
None
FE  A 425 (-2.5A)
 0.99A 1kw0A-1dmwA:
42.7		 1kw0A-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
 None
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.92A 1kw0A-1dmwA:
42.7		 1kw0A-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
HIS A 290
TYR A 325
GLU A 330
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 1.01A 1mmkA-1dmwA:
42.9		 1mmkA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
HIS A 290
TYR A 325
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.94A 1mmkA-1dmwA:
42.9		 1mmkA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
LEU A 249
PHE A 254
LEU A 255
GLU A 286
HIS A 290
TYR A 325
GLU A 330
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.90A 1mmkA-1dmwA:
42.9		 1mmkA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
LEU A 249
SER A 251
PHE A 254
LEU A 255
GLU A 286
HIS A 290
TYR A 325
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.88A 1mmkA-1dmwA:
42.9		 1mmkA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
PHE A 254
LEU A 255
GLU A 286
HIS A 290
TYR A 325
TRP A 326
GLU A 330
 None
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
None
FE  A 425 (-2.5A)
 0.95A 1mmkA-1dmwA:
42.9		 1mmkA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
HIS A 290
TYR A 325
GLU A 330
 HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.98A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
HIS A 290
TYR A 325
 HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.92A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 LEU A 249
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
GLU A 330
 HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.87A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
 HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.87A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
HIS A 290
GLU A 330
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
FE  A 425 (-2.5A)
 0.99A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
HIS A 290
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
 0.92A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 VAL A 245
LEU A 249
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
GLU A 330
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
FE  A 425 (-2.5A)
 0.83A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 VAL A 245
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
 0.83A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 LEU A 227
VAL A 230
LEU A 234
 None
 0.53A 1mz9B-1dmwA:
undetectable		 1mz9B-1dmwA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 7 LEU A 258
PHE A 302
PHE A 294
PHE A 299
 None
 0.95A 1wrlE-1dmwA:
0.0
1wrlF-1dmwA:
undetectable		 1wrlE-1dmwA:
15.77
1wrlF-1dmwA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 ARG A 176
GLU A 228
GLN A 226
 None
 0.96A 2p16A-1dmwA:
0.0		 2p16A-1dmwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 ARG A 270
THR A 193
VAL A 190
 None
 0.88A 2q64A-1dmwA:
0.0		 2q64A-1dmwA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 PHE A 233
CYH A 217
PHE A 219
 None
 0.82A 3cr5X-1dmwA:
0.6		 3cr5X-1dmwA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		5 / 12 ARG A 252
GLY A 312
GLY A 307
GLY A 256
ALA A 309
 None
 0.98A 3kkzB-1dmwA:
undetectable		 3kkzB-1dmwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 7 LEU A 321
GLY A 257
ALA A 259
PHE A 260
 None
 1.00A 3tehB-1dmwA:
0.0		 3tehB-1dmwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 SER A 303
PHE A 392
LYS A 396
 None
 1.00A 3u88A-1dmwA:
0.0		 3u88A-1dmwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		5 / 12 THR A 238
SER A 295
LEU A 213
VAL A 291
CYH A 217
 None
 1.27A 3u9fG-1dmwA:
0.0
3u9fH-1dmwA:
0.0		 3u9fG-1dmwA:
19.63
3u9fH-1dmwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 PHE A 331
SER A 349
SER A 350
 None
 0.95A 3ufgB-1dmwA:
0.0		 3ufgB-1dmwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 5 LEU A 248
HIS A 285
GLU A 286
HIS A 290
 HBI  A 700 ( 4.5A)
FE  A 425 (-3.4A)
None
FE  A 425 (-3.3A)
 1.23A 4a7bB-1dmwA:
undetectable		 4a7bB-1dmwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 5 HIS A 170
LEU A 227
LEU A 234
ASP A 229
 None
 1.17A 4aqlA-1dmwA:
undetectable		 4aqlA-1dmwA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		6 / 6 LEU A 248
PHE A 254
HIS A 285
HIS A 290
TYR A 325
GLU A 330
 HBI  A 700 ( 4.5A)
HBI  A 700 (-3.6A)
FE  A 425 (-3.4A)
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.40A 4pahA-1dmwA:
53.5		 4pahA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 6 LEU A 128
LEU A 255
PHE A 254
VAL A 245
 None
HBI  A 700 (-4.7A)
HBI  A 700 (-3.6A)
None
 0.97A 4udaA-1dmwA:
undetectable		 4udaA-1dmwA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		3 / 3 GLU A 183
ILE A 164
ALA A 156
 None
 0.60A 4wnwB-1dmwA:
0.0		 4wnwB-1dmwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 7 ASP A 282
ILE A 269
GLY A 272
THR A 278
 None
 1.09A 4zxiA-1dmwA:
undetectable		 4zxiA-1dmwA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 4 TYR A 198
GLY A 352
SER A 350
LEU A 354
 None
 1.38A 5bphC-1dmwA:
0.0		 5bphC-1dmwA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 4 HIS A 285
HIS A 290
TYR A 325
GLU A 330
 FE  A 425 (-3.4A)
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.13A 5pahA-1dmwA:
53.1		 5pahA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 8 GLY A 289
ARG A 270
TYR A 179
ASP A 282
 None
 0.98A 5vlmB-1dmwA:
0.0		 5vlmB-1dmwA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 8 GLY A 289
TRP A 187
ARG A 270
ASP A 282
 None
 1.01A 5vlmB-1dmwA:
0.0		 5vlmB-1dmwA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 6 GLY A 188
THR A 189
LYS A 192
LYS A 195
 None
 0.95A 5xxiA-1dmwA:
0.0		 5xxiA-1dmwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 6 PHE A 240
VAL A 329
LEU A 255
LEU A 258
 None
None
HBI  A 700 (-4.7A)
None
 0.98A 6e43C-1dmwA:
0.0		 6e43C-1dmwA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		6 / 6 LEU A 248
PRO A 281
HIS A 285
HIS A 290
TYR A 325
GLU A 330
 HBI  A 700 ( 4.5A)
None
FE  A 425 (-3.4A)
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.51A 6pahA-1dmwA:
53.1		 6pahA-1dmwA:
100.00