SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dnp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		3 / 4 VAL A 429
TRP A 434
TRP A 436
 None
 1.22A 1gmkA-1dnpA:
undetectable
1gmkB-1dnpA:
undetectable		 1gmkA-1dnpA:
3.23
1gmkB-1dnpA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 9 CYH A 215
LEU A 256
ALA A 262
LEU A 263
LEU A 272
 None
 1.33A 1hwiA-1dnpA:
undetectable		 1hwiA-1dnpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 11 SER A 335
THR A 336
ILE A 346
THR A 347
VAL A 326
 None
 0.99A 1pkvA-1dnpA:
undetectable
1pkvB-1dnpA:
undetectable		 1pkvA-1dnpA:
11.13
1pkvB-1dnpA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 11 VAL A 326
SER A 335
THR A 336
ILE A 346
THR A 347
 None
 0.98A 1pkvA-1dnpA:
undetectable
1pkvB-1dnpA:
undetectable		 1pkvA-1dnpA:
11.13
1pkvB-1dnpA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 12 GLN A 369
GLY A 362
SER A 368
LEU A 313
LEU A 351
 None
 1.03A 1rjdA-1dnpA:
2.9		 1rjdA-1dnpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 12 GLN A 369
GLY A 362
SER A 368
LEU A 313
LEU A 351
 None
 1.03A 1rjdB-1dnpA:
undetectable		 1rjdB-1dnpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 12 GLN A 369
GLY A 362
SER A 368
LEU A 313
LEU A 351
 None
 1.00A 1rjdC-1dnpA:
2.3		 1rjdC-1dnpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 12 LEU A 272
LEU A 275
ILE A 276
LEU A 158
LEU A 255
 None
FAD  A 472 ( 4.7A)
None
None
None
 1.26A 1xdkB-1dnpA:
0.0		 1xdkB-1dnpA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 12 ILE A  54
LEU A  53
GLY A 244
GLN A 250
ARG A 249
 None
 1.32A 2e7fB-1dnpA:
undetectable		 2e7fB-1dnpA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		4 / 6 ARG A  75
ASN A  94
ASN A 102
LEU A  19
 None
 1.28A 2nyrA-1dnpA:
1.5		 2nyrA-1dnpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 12 ILE A  54
LEU A  53
GLY A 244
GLN A 250
ARG A 249
 None
 1.36A 2ogyB-1dnpA:
undetectable		 2ogyB-1dnpA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		4 / 6 MET A 339
ILE A 346
ARG A 342
SER A 238
 None
None
None
FAD  A 472 (-3.2A)
 1.46A 2qd3B-1dnpA:
1.7		 2qd3B-1dnpA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 8 ALA A  64
LEU A  13
LEU A  19
ILE A  70
VAL A   5
 None
 1.25A 2uxpA-1dnpA:
undetectable		 2uxpA-1dnpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 11 HIS A 340
ALA A 230
GLU A 413
GLY A 412
ILE A 415
 None
 1.27A 2uxpB-1dnpA:
0.7		 2uxpB-1dnpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		4 / 6 TRP A  41
SER A  83
ALA A  82
ASP A  78
 None
 1.35A 3aruA-1dnpA:
0.0		 3aruA-1dnpA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		4 / 7 ASP A 113
TRP A   6
SER A  83
THR A  37
 None
 1.24A 3dzgB-1dnpA:
undetectable		 3dzgB-1dnpA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		4 / 8 ASP A 130
SER A 131
ARG A 249
GLY A 245
 None
 0.88A 4af0A-1dnpA:
undetectable		 4af0A-1dnpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 11 GLY A 319
ALA A 348
VAL A 326
PRO A 447
ILE A 450
 None
FAD  A 472 ( 3.7A)
None
None
None
 1.09A 4j4vA-1dnpA:
0.0		 4j4vA-1dnpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 11 GLY A 319
ALA A 348
VAL A 326
PRO A 447
ILE A 450
 None
FAD  A 472 ( 3.7A)
None
None
None
 1.16A 4j4vD-1dnpA:
0.6
4j4vE-1dnpA:
undetectable		 4j4vD-1dnpA:
21.51
4j4vE-1dnpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		4 / 6 HIS A  14
VAL A 169
ARG A 249
HIS A 253
 None
 1.38A 5kkzA-1dnpA:
0.0
5kkzG-1dnpA:
0.0		 5kkzA-1dnpA:
23.91
5kkzG-1dnpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		4 / 6 HIS A  14
VAL A 169
GLN A 250
HIS A 253
 None
 1.47A 5kkzA-1dnpA:
0.0
5kkzG-1dnpA:
0.0		 5kkzA-1dnpA:
23.91
5kkzG-1dnpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 12 VAL A 169
ARG A 249
LEU A 161
ARG A 160
ILE A 133
 None
 1.47A 5uahC-1dnpA:
0.0		 5uahC-1dnpA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 12 ILE A 133
ARG A 160
LEU A 161
GLY A 137
ALA A 138
 None
 1.18A 5zwrA-1dnpA:
undetectable		 5zwrA-1dnpA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1dnp DNA PHOTOLYASE
(Escherichia
coli) 		5 / 12 GLY A 266
ALA A 262
ASP A 264
ILE A 276
LEU A 158
 None
 1.09A 6dwnD-1dnpA:
0.0		 6dwnD-1dnpA:
9.34