SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1do5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.63A 1rjoA-1do5A:
undetectable
1rjoA-1do5A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.69A 1rkyA-1do5A:
undetectable
1rkyA-1do5A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 1v54A-1do5A:
undetectable
1v54A-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 1v54N-1do5A:
undetectable
1v54N-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.58A 1w2zA-1do5A:
undetectable
1w2zA-1do5A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.58A 1w2zB-1do5A:
undetectable
1w2zB-1do5A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.59A 1w2zC-1do5A:
undetectable
1w2zC-1do5A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.60A 1w2zD-1do5A:
undetectable
1w2zD-1do5A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 2dyrN-1do5A:
undetectable
2dyrN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.72A 2dysA-1do5A:
undetectable
2dysA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.71A 2dysN-1do5A:
undetectable
2dysN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.73A 2eikA-1do5A:
undetectable
2eikA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.72A 2eilA-1do5A:
undetectable
2eilA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.76A 2eilN-1do5A:
undetectable
2eilN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.67A 2einA-1do5A:
undetectable
2einA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
4 / 6 ASP A 167
ARG A 163
ASP A 151
ASP A 185
ZN  A  28 (-2.2A)
None
None
None
0.81A 2j2pE-1do5A:
0.0
2j2pF-1do5A:
0.0
2j2pE-1do5A:
22.57
2j2pF-1do5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
5 / 8 ILE A 200
ILE A 199
ILE A 230
ILE A 119
ASN A 140
None
1.18A 2nniA-1do5A:
0.0
2nniA-1do5A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.56A 2oqeA-1do5A:
undetectable
2oqeA-1do5A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.55A 2oqeB-1do5A:
undetectable
2oqeB-1do5A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.57A 2oqeC-1do5A:
undetectable
2oqeC-1do5A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.57A 2oqeD-1do5A:
undetectable
2oqeD-1do5A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.56A 2oqeF-1do5A:
undetectable
2oqeF-1do5A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
4 / 8 GLN A 107
ARG A 163
ASP A 185
GLY A 166
None
0.86A 2qqcH-1do5A:
0.0
2qqcK-1do5A:
undetectable
2qqcH-1do5A:
18.83
2qqcK-1do5A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
5 / 9 ALA A  91
ALA A 226
GLY A  94
GLY A 101
ILE A 119
None
1.19A 2v7bA-1do5A:
undetectable
2v7bA-1do5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
5 / 9 ALA A  91
ALA A 226
GLY A  94
GLY A 101
ILE A 119
None
1.19A 2v7bB-1do5A:
undetectable
2v7bB-1do5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.67A 2w0qA-1do5A:
undetectable
2w0qA-1do5A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.60A 2w0qB-1do5A:
undetectable
2w0qB-1do5A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.73A 2y69A-1do5A:
undetectable
2y69A-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.70A 2zxwA-1do5A:
undetectable
2zxwA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 2zxwN-1do5A:
undetectable
2zxwN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.71A 3ablA-1do5A:
undetectable
3ablA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.69A 3ablN-1do5A:
undetectable
3ablN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.74A 3abmA-1do5A:
undetectable
3abmA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.73A 3abmN-1do5A:
undetectable
3abmN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.74A 3ag2A-1do5A:
undetectable
3ag2A-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.76A 3ag2N-1do5A:
undetectable
3ag2N-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.76A 3ag3A-1do5A:
undetectable
3ag3A-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 3ag3N-1do5A:
undetectable
3ag3N-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 3asnA-1do5A:
undetectable
3asnA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.74A 3asnN-1do5A:
undetectable
3asnN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 3asoA-1do5A:
undetectable
3asoA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.73A 3asoN-1do5A:
undetectable
3asoN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
5 / 12 GLY A 203
GLY A 222
ILE A 119
LEU A 129
GLY A 128
None
0.82A 3axzA-1do5A:
undetectable
3axzA-1do5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
4 / 7 VAL A 102
LEU A 106
LEU A 168
ILE A  92
None
0.95A 3gp0A-1do5A:
undetectable
3gp0A-1do5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.58A 3hiiA-1do5A:
2.2
3hiiA-1do5A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
HIS A 132
HIS A 130
ZN  A  28 (-3.1A)
None
None
0.60A 3hiiB-1do5A:
undetectable
3hiiB-1do5A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
4 / 8 ASP A 136
GLY A 228
SER A 197
ILE A 229
None
0.67A 3ihzB-1do5A:
undetectable
3ihzB-1do5A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.78A 3s39A-1do5A:
undetectable
3s39A-1do5A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 3s3dA-1do5A:
undetectable
3s3dA-1do5A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.73A 3wg7A-1do5A:
undetectable
3wg7A-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.74A 3wg7N-1do5A:
undetectable
3wg7N-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 3x2qA-1do5A:
undetectable
3x2qA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
5 / 7 ALA A  91
ALA A 226
GLY A  94
GLY A 101
ILE A 119
None
1.17A 4eatA-1do5A:
undetectable
4eatA-1do5A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
5 / 12 GLY A 203
GLY A 222
ILE A 119
LEU A 129
GLY A 128
None
0.81A 4yvgA-1do5A:
undetectable
4yvgA-1do5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
5 / 12 LEU A 122
PHE A 181
LEU A 129
GLY A 117
LEU A  93
None
1.33A 4zbrA-1do5A:
undetectable
4zbrA-1do5A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.74A 5b1aA-1do5A:
undetectable
5b1aA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 5b1aN-1do5A:
undetectable
5b1aN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 ARG A 104
ILE A 115
PHE A 105
None
0.74A 5kirA-1do5A:
0.0
5kirA-1do5A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 147
ASP A 167
HIS A 155
ZN  A  28 (-3.1A)
ZN  A  28 (-2.2A)
ZN  A  28 (-3.2A)
0.73A 5n1tW-1do5A:
2.7
5n1tW-1do5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 132
HIS A 147
HIS A 130
None
ZN  A  28 (-3.1A)
None
0.83A 5oexA-1do5A:
undetectable
5oexA-1do5A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
4 / 8 VAL A  99
ASP A 120
HIS A 127
GLY A 117
None
0.93A 5w3jB-1do5A:
undetectable
5w3jB-1do5A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_1
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
4 / 4 SER A 221
ASP A 167
HIS A 164
ASP A 206
None
ZN  A  28 (-2.2A)
ZN  A  28 (-3.3A)
None
0.93A 5x7fA-1do5A:
0.0
5x7fA-1do5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.73A 5xdqA-1do5A:
undetectable
5xdqA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.76A 5xdqN-1do5A:
undetectable
5xdqN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.71A 5z84A-1do5A:
undetectable
5z84A-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.76A 5z84N-1do5A:
undetectable
5z84N-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.74A 5z85A-1do5A:
undetectable
5z85A-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.74A 5z85N-1do5A:
undetectable
5z85N-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.72A 5z86A-1do5A:
undetectable
5z86A-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.77A 5z86N-1do5A:
undetectable
5z86N-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.73A 5zcoA-1do5A:
undetectable
5zcoA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.74A 5zcoN-1do5A:
undetectable
5zcoN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.71A 5zcpA-1do5A:
undetectable
5zcpA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.75A 5zcpN-1do5A:
undetectable
5zcpN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.71A 5zcqA-1do5A:
undetectable
5zcqA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.73A 5zcqN-1do5A:
undetectable
5zcqN-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
5 / 12 GLY A 203
GLY A 222
ILE A 119
LEU A 129
GLY A 128
None
0.80A 5zhmB-1do5A:
undetectable
5zhmB-1do5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.71A 6nknA-1do5A:
undetectable
6nknA-1do5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo
sapiens)
3 / 3 HIS A 130
HIS A 147
HIS A 132
None
ZN  A  28 (-3.1A)
None
0.71A 6nknN-1do5A:
undetectable
6nknN-1do5A:
15.95