SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		4 / 4 ARG A 131
ALA A 127
ALA A 397
GLU A 395
 None
 1.23A 1e7bA-1dofA:
2.9		 1e7bA-1dofA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 100
ALA A 103
LEU A  35
ALA A  34
ILE A  99
 None
 1.26A 1g5yB-1dofA:
0.4		 1g5yB-1dofA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A  29
LEU A  35
VAL A  36
SER A 190
VAL A  78
 None
 1.18A 1s19A-1dofA:
2.4		 1s19A-1dofA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		5 / 12 VAL A 290
LEU A 170
ALA A 229
LEU A 226
ALA A 316
 None
 1.03A 1sa1A-1dofA:
undetectable
1sa1B-1dofA:
undetectable		 1sa1A-1dofA:
20.00
1sa1B-1dofA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		5 / 12 VAL A 290
LEU A 170
ALA A 229
LEU A 226
ALA A 316
 None
 1.04A 1sa1C-1dofA:
undetectable
1sa1D-1dofA:
undetectable		 1sa1C-1dofA:
20.00
1sa1D-1dofA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		4 / 5 ALA A 179
ILE A 181
ILE A  99
ASP A  98
 None
 1.09A 2h4jA-1dofA:
undetectable		 2h4jA-1dofA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		4 / 5 LEU A 112
ARG A 109
ALA A 111
ILE A 177
 None
 1.17A 2qhfA-1dofA:
undetectable		 2qhfA-1dofA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		4 / 6 GLU A 174
ALA A 105
LEU A 107
THR A 102
 None
 1.09A 2roxB-1dofA:
undetectable		 2roxB-1dofA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		5 / 8 GLY A 192
GLY A 195
GLY A  93
ILE A 181
LEU A  35
 None
 0.99A 3v1nA-1dofA:
undetectable		 3v1nA-1dofA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		5 / 11 VAL A 202
ALA A  38
LEU A  35
VAL A  44
GLY A 195
 None
 0.93A 3zosA-1dofA:
0.6
3zosB-1dofA:
0.6		 3zosA-1dofA:
22.54
3zosB-1dofA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		5 / 9 LEU A 208
GLY A 207
GLU A  30
ILE A 181
THR A 102
 None
 1.42A 4x3mA-1dofA:
undetectable		 4x3mA-1dofA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		5 / 10 ARG A 110
PHE A  19
LEU A 226
ILE A 313
ALA A 105
 None
 1.44A 4z69I-1dofA:
0.0		 4z69I-1dofA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		4 / 5 SER A 367
ARG A 360
THR A 382
GLU A 384
 None
 1.15A 5btiA-1dofA:
0.4
5btiB-1dofA:
undetectable		 5btiA-1dofA:
23.86
5btiB-1dofA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		4 / 5 SER A 367
ARG A 360
THR A 382
GLU A 384
 None
 1.19A 5btiC-1dofA:
0.3
5btiD-1dofA:
undetectable		 5btiC-1dofA:
23.86
5btiD-1dofA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		5 / 12 PHE A  19
LEU A 112
ALA A 111
ILE A  99
ARG A 109
 None
 1.16A 5h8tA-1dofA:
undetectable		 5h8tA-1dofA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		5 / 10 ILE A  24
ILE A  25
ILE A  74
ILE A 100
ILE A  99
 None
 0.98A 5murE-1dofA:
2.6		 5murE-1dofA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		4 / 8 ALA A 119
VAL A 122
LEU A 331
ILE A 277
 None
 0.73A 5nujA-1dofA:
undetectable		 5nujA-1dofA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1dof ADENYLOSUCCINATE
LYASE
(Pyrobaculum
aerophilum) 		4 / 5 LEU A 398
ILE A 323
MET A 129
GLY A 153
 None
 1.06A 6hd6A-1dofA:
undetectable		 6hd6A-1dofA:
10.42