SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1doi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_B_SAMB1002_1 (SAM DEPENDENT METHYLTRANSFERASE)	1doi	2FE-2S FERREDOXIN (Haloarcula marismortui)	3 / 3	ASP A 12 ASP A 17 ASP A 121	K A 201 (-3.4A) None None	0.78A	2igtB-1doiA: undetectable	2igtB-1doiA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G1Q_A_T27A601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1doi	2FE-2S FERREDOXIN (Haloarcula marismortui)	5 / 12	PRO A 60 VAL A 3 TYR A 115 TYR A 5 PRO A 106	K A 204 ( 4.6A) None None None None	1.24A	4g1qA-1doiA: 0.0	4g1qA-1doiA: 14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ID5_A_T27A601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1doi	2FE-2S FERREDOXIN (Haloarcula marismortui)	5 / 12	PRO A 60 VAL A 3 TYR A 115 TYR A 5 PRO A 106	K A 204 ( 4.6A) None None None None	1.25A	4id5A-1doiA: undetectable	4id5A-1doiA: 14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IFV_A_T27A601_1 (EXORIBONUCLEASE H, P66 RT)	1doi	2FE-2S FERREDOXIN (Haloarcula marismortui)	5 / 12	PRO A 60 VAL A 3 TYR A 115 TYR A 5 PRO A 106	K A 204 ( 4.6A) None None None None	1.22A	4ifvA-1doiA: undetectable	4ifvA-1doiA: 14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IFY_A_T27A601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1doi	2FE-2S FERREDOXIN (Haloarcula marismortui)	5 / 12	PRO A 60 VAL A 3 TYR A 115 TYR A 5 PRO A 106	K A 204 ( 4.6A) None None None None	1.24A	4ifyA-1doiA: undetectable	4ifyA-1doiA: 14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IG3_A_T27A601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1doi	2FE-2S FERREDOXIN (Haloarcula marismortui)	5 / 12	PRO A 60 VAL A 3 TYR A 115 TYR A 5 PRO A 106	K A 204 ( 4.6A) None None None None	1.24A	4ig3A-1doiA: undetectable	4ig3A-1doiA: 14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KFB_A_T27A607_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H, EXORIBONUCLEA P66 RT)	1doi	2FE-2S FERREDOXIN (Haloarcula marismortui)	5 / 12	PRO A 60 VAL A 3 TYR A 115 TYR A 5 PRO A 106	K A 204 ( 4.6A) None None None None	1.29A	4kfbA-1doiA: undetectable	4kfbA-1doiA: 14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R87_H_SPMH202_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	1doi	2FE-2S FERREDOXIN (Haloarcula marismortui)	4 / 6	ASN A 116 GLU A 9 TYR A 5 GLU A 35	None	1.37A	4r87H-1doiA: 0.0	4r87H-1doiA: 23.20

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2IGT_B_SAMB1002_1","SAM DEPENDENT METHYLTRANSFERASE","1doi","2FE-2S FERREDOXIN","Haloarcula marismortui",3,"ASP A  12;ASP A  17;ASP A 121","  K A 201 (-3.4A);None;None","0.78A","2igtB-1doiA:undetectable","2igtB-1doiA:19.45"],["4G1Q_A_T27A601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1doi","2FE-2S FERREDOXIN","Haloarcula marismortui",5,"PRO A  60;VAL A   3;TYR A 115;TYR A   5;PRO A 106","  K A 204 ( 4.6A);None;None;None;None","1.24A","4g1qA-1doiA:0.0","4g1qA-1doiA:14.15"],["4ID5_A_T27A601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1doi","2FE-2S FERREDOXIN","Haloarcula marismortui",5,"PRO A  60;VAL A   3;TYR A 115;TYR A   5;PRO A 106","  K A 204 ( 4.6A);None;None;None;None","1.25A","4id5A-1doiA:undetectable","4id5A-1doiA:14.15"],["4IFV_A_T27A601_1","EXORIBONUCLEASE H, P66 RT","1doi","2FE-2S FERREDOXIN","Haloarcula marismortui",5,"PRO A  60;VAL A   3;TYR A 115;TYR A   5;PRO A 106","  K A 204 ( 4.6A);None;None;None;None","1.22A","4ifvA-1doiA:undetectable","4ifvA-1doiA:14.15"],["4IFY_A_T27A601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1doi","2FE-2S FERREDOXIN","Haloarcula marismortui",5,"PRO A  60;VAL A   3;TYR A 115;TYR A   5;PRO A 106","  K A 204 ( 4.6A);None;None;None;None","1.24A","4ifyA-1doiA:undetectable","4ifyA-1doiA:14.15"],["4IG3_A_T27A601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1doi","2FE-2S FERREDOXIN","Haloarcula marismortui",5,"PRO A  60;VAL A   3;TYR A 115;TYR A   5;PRO A 106","  K A 204 ( 4.6A);None;None;None;None","1.24A","4ig3A-1doiA:undetectable","4ig3A-1doiA:14.15"],["4KFB_A_T27A607_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H, EXORIBONUCLEA P66 RT","1doi","2FE-2S FERREDOXIN","Haloarcula marismortui",5,"PRO A  60;VAL A   3;TYR A 115;TYR A   5;PRO A 106","  K A 204 ( 4.6A);None;None;None;None","1.29A","4kfbA-1doiA:undetectable","4kfbA-1doiA:14.15"],["4R87_H_SPMH202_1","SPERMIDINE N1-ACETYLTRANSFERASE","1doi","2FE-2S FERREDOXIN","Haloarcula marismortui",4,"ASN A 116;GLU A   9;TYR A   5;GLU A  35","None","1.37A","4r87H-1doiA:0.0","4r87H-1doiA:23.20"]]