SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		3 / 3 GLU A  80
HIS A 250
ASP A 302
 None
FE  A 687 (-3.2A)
None
 0.79A 1i9gA-1dotA:
undetectable		 1i9gA-1dotA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		4 / 8 SER A 517
SER A 516
GLY A 491
GLY A 504
 None
 0.73A 1me7A-1dotA:
undetectable		 1me7A-1dotA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 11 THR A  11
VAL A 252
GLU A  16
GLU A  80
LEU A 284
 None
 1.46A 1t6zA-1dotA:
undetectable		 1t6zA-1dotA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		4 / 7 SER A 114
SER A 159
VAL A 161
LEU A 331
 None
 0.91A 2hdnE-1dotA:
0.0
2hdnF-1dotA:
undetectable
2hdnH-1dotA:
undetectable		 2hdnE-1dotA:
5.06
2hdnF-1dotA:
19.74
2hdnH-1dotA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		4 / 7 SER A 159
VAL A 161
LEU A 331
SER A 114
 None
 0.88A 2hdnF-1dotA:
undetectable
2hdnG-1dotA:
0.0
2hdnH-1dotA:
undetectable		 2hdnF-1dotA:
19.74
2hdnG-1dotA:
5.06
2hdnH-1dotA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 10 ILE A 138
ILE A 129
GLY A 124
PRO A 162
LEU A 109
 None
None
CO3  A 689 (-3.7A)
None
None
 1.24A 3elzB-1dotA:
0.0		 3elzB-1dotA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 12 ALA A  94
ILE A 138
TRP A 125
PHE A 207
HIS A 116
 None
 1.25A 3wenA-1dotA:
undetectable		 3wenA-1dotA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 12 ALA A  94
ILE A 138
TRP A 125
PHE A 207
HIS A 116
 None
 1.25A 3weoA-1dotA:
undetectable		 3weoA-1dotA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 12 ALA A 601
GLN A 649
ASN A 602
GLU A 655
LEU A 407
 None
 1.23A 4azwA-1dotA:
undetectable		 4azwA-1dotA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		3 / 3 LYS A 296
PRO A 293
LYS A 290
 None
 1.49A 4duzL-1dotA:
0.0		 4duzL-1dotA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		4 / 4 PRO A 128
LEU A 132
ILE A 138
ARG A 110
 None
 1.30A 4f4dA-1dotA:
0.7		 4f4dA-1dotA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 9 SER A 316
ILE A 260
ALA A 254
LEU A  74
ALA A  67
 None
 1.38A 4fe1B-1dotA:
undetectable		 4fe1B-1dotA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		4 / 7 ILE A 127
ALA A 245
TYR A 324
ALA A 327
 None
 0.31A 4g77A-1dotA:
41.0		 4g77A-1dotA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 7 ILE A 466
LEU A 470
HIS A 585
ALA A 587
TYR A 661
 None
NAG  A 691 (-4.2A)
None
None
None
 0.48A 4g77A-1dotA:
41.0		 4g77A-1dotA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 9 VAL A 399
ALA A 402
GLY A 412
PHE A 656
SER A 393
 None
 1.38A 4mmfB-1dotA:
0.0		 4mmfB-1dotA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 12 SER A 674
THR A 401
ASP A 395
ASP A 634
LYS A 378
 None
None
CO3  A 690 (-3.6A)
None
None
 1.33A 4pghB-1dotA:
undetectable		 4pghB-1dotA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		3 / 3 GLU A  80
HIS A 250
ASP A 302
 None
FE  A 687 (-3.2A)
None
 0.81A 5c0oG-1dotA:
undetectable		 5c0oG-1dotA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		3 / 3 LEU A  69
TYR A 325
SER A 316
 None
 0.79A 5iktA-1dotA:
0.0		 5iktA-1dotA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		3 / 3 HIS A 585
LYS A 582
PHE A 432
 None
 1.07A 5klaA-1dotA:
undetectable		 5klaA-1dotA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 9 GLU A 519
VAL A 514
GLY A 506
SER A 505
LEU A 510
 None
 1.50A 5ksnB-1dotA:
undetectable		 5ksnB-1dotA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		5 / 7 LEU A 394
GLY A 397
GLY A 459
THR A 401
ALA A 402
 None
 1.34A 5o96C-1dotA:
undetectable		 5o96C-1dotA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 1dot DUCK OVOTRANSFERRIN
(Anas
platyrhynchos) 		4 / 6 LYS A 654
PHE A 656
VAL A 408
PRO A 409
 None
 1.48A 6fgdA-1dotA:
2.6		 6fgdA-1dotA:
20.89