SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 1dow ALPHA-CATENIN
(Mus
musculus) 		5 / 12 ALA A  93
GLY A 101
LEU A 103
ASP A  96
LEU A 138
 None
 1.28A 2nv4A-1dowA:
undetectable		 2nv4A-1dowA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1dow ALPHA-CATENIN
(Mus
musculus) 		5 / 12 ALA A  93
GLY A 101
LEU A 103
ASP A  96
LEU A 138
 None
 1.28A 2nv4B-1dowA:
undetectable		 2nv4B-1dowA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1dow ALPHA-CATENIN
BETA-CATENIN
(Mus
musculus;
Mus
musculus) 		3 / 3 MET A 207
GLU A 197
ASN B 121
 None
 0.93A 3a27A-1dowA:
undetectable		 3a27A-1dowA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1dow ALPHA-CATENIN
(Mus
musculus) 		3 / 3 LYS A 178
LYS A 181
PRO A 182
 None
 0.97A 4dv1L-1dowA:
undetectable		 4dv1L-1dowA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 1dow ALPHA-CATENIN
BETA-CATENIN
(Mus
musculus;
Mus
musculus) 		3 / 3 ARG B 124
LYS A  75
LYS A  78
 None
 1.32A 4k50A-1dowB:
undetectable		 4k50A-1dowB:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1dow ALPHA-CATENIN
BETA-CATENIN
(Mus
musculus;
Mus
musculus) 		3 / 3 ARG B 124
LYS A  75
LYS A  78
 None
 1.36A 4k50E-1dowB:
undetectable		 4k50E-1dowB:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1dow ALPHA-CATENIN
BETA-CATENIN
(Mus
musculus;
Mus
musculus) 		3 / 3 ARG B 124
LYS A  75
LYS A  78
 None
 1.35A 4k50I-1dowB:
undetectable		 4k50I-1dowB:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1dow ALPHA-CATENIN
(Mus
musculus) 		4 / 6 SER A 117
GLY A 109
GLU A 110
ASP A 113
 None
 0.81A 4uckB-1dowA:
undetectable		 4uckB-1dowA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1dow ALPHA-CATENIN
BETA-CATENIN
(Mus
musculus;
Mus
musculus) 		4 / 6 LYS B 133
LEU B 132
LEU A 139
VAL A 135
 None
 1.17A 4uswA-1dowB:
undetectable		 4uswA-1dowB:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 1dow ALPHA-CATENIN
BETA-CATENIN
(Mus
musculus) 		5 / 12 LEU B 132
ILE B 140
ALA A 108
MET A 124
LEU A  61
 None
 1.13A 5og9B-1dowB:
undetectable		 5og9B-1dowB:
8.50