SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		4 / 5 LEU A 545
GLU A 535
ALA A 537
LEU A 514
 None
 1.15A 1eta1-1dpbA:
0.0		 1eta1-1dpbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		4 / 5 LEU A 545
GLU A 535
ALA A 537
LEU A 514
 None
 1.15A 1eta2-1dpbA:
undetectable		 1eta2-1dpbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		4 / 6 LEU A 545
GLU A 535
ALA A 537
LEU A 514
 None
 1.12A 1etb1-1dpbA:
0.0		 1etb1-1dpbA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 467
ALA A 533
LEU A 536
PRO A 516
ILE A 503
 None
 1.31A 1mx8A-1dpbA:
undetectable		 1mx8A-1dpbA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		4 / 5 LEU A 629
GLY A 561
ALA A 441
ILE A 443
 None
 0.81A 2aohB-1dpbA:
undetectable		 2aohB-1dpbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		5 / 11 GLY A 565
SER A 583
ASP A 508
GLY A 561
HIS A 562
 None
 1.02A 2hmaA-1dpbA:
undetectable		 2hmaA-1dpbA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 625
ALA A 475
ASP A 522
ILE A 635
LEU A 629
 None
 1.00A 2o4nA-1dpbA:
undetectable		 2o4nA-1dpbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		5 / 9 PRO A 468
LEU A 469
ALA A 530
LEU A 526
PHE A 449
 None
 0.99A 2vcvD-1dpbA:
undetectable		 2vcvD-1dpbA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		3 / 3 PRO A 510
THR A 509
LEU A 417
 None
 0.71A 3ttrA-1dpbA:
undetectable		 3ttrA-1dpbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		4 / 6 PHE A 555
ALA A 578
GLY A 581
LEU A 606
 None
 0.91A 4dubB-1dpbA:
0.0		 4dubB-1dpbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		5 / 12 GLN A 437
LEU A 606
GLY A 626
ALA A 630
ALA A 441
 None
 1.34A 4pclB-1dpbA:
undetectable		 4pclB-1dpbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		4 / 4 ILE A 635
ARG A 624
TYR A 476
GLU A 480
 None
 1.40A 4zzbD-1dpbA:
undetectable		 4zzbD-1dpbA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		4 / 8 LEU A 477
PHE A 555
ILE A 503
LEU A 629
 None
 0.85A 5eseA-1dpbA:
undetectable		 5eseA-1dpbA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 477
PHE A 555
ILE A 503
PHE A 621
LEU A 629
 None
 1.08A 5fsaA-1dpbA:
undetectable		 5fsaA-1dpbA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 1dpb DIHYDROLIPOYL-TRANSA
CETYLASE
(Azotobacter
vinelandii) 		5 / 12 ILE A 632
PHE A 449
ALA A 473
LEU A 527
LEU A 464
 None
 1.19A 5jkvA-1dpbA:
0.0		 5jkvA-1dpbA:
17.98