SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 PHE A 137
SER A  93
ALA A 155
ILE A 157
 None
 1.05A 1fxhA-1dppA:
undetectable
1fxhB-1dppA:
0.0		 1fxhA-1dppA:
18.00
1fxhB-1dppA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 ILE A 218
PRO A  11
PHE A  14
ALA A  27
 None
 1.01A 1oniD-1dppA:
0.0
1oniE-1dppA:
0.0		 1oniD-1dppA:
14.26
1oniE-1dppA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 PHE A  14
ALA A  27
ILE A 218
PRO A  11
 None
 1.00A 1oniH-1dppA:
0.0
1oniI-1dppA:
0.0		 1oniH-1dppA:
14.26
1oniI-1dppA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A  50
LEU A  36
LEU A 150
ALA A 155
THR A 182
 None
 1.16A 1ya3C-1dppA:
undetectable		 1ya3C-1dppA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 TYR A  63
LEU A 139
ILE A 124
LEU A 123
PHE A  94
 None
 1.28A 2qo6A-1dppA:
undetectable		 2qo6A-1dppA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 ILE A 157
ASP A  89
ARG A  83
TRP A  73
 None
 0.92A 2v57A-1dppA:
0.0		 2v57A-1dppA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 ILE A 157
ASP A  89
ARG A  83
TRP A  73
 None
 0.92A 2v57C-1dppA:
0.0		 2v57C-1dppA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 175
PHE A  92
PRO A  16
ILE A 157
SER A  93
 None
 1.39A 2xpwA-1dppA:
undetectable		 2xpwA-1dppA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 389
VAL A 401
THR A 383
 None
 0.74A 2ygnA-1dppA:
0.2		 2ygnA-1dppA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 GLN A  17
PHE A 115
LEU A 150
PHE A  65
 None
 1.36A 3ablC-1dppA:
1.4
3ablJ-1dppA:
0.0		 3ablC-1dppA:
20.58
3ablJ-1dppA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 PHE A 146
LEU A 123
GLU A 143
ARG A 141
TYR A  63
 None
 1.42A 3apwB-1dppA:
0.0		 3apwB-1dppA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 PHE A  94
ALA A 155
THR A 182
LEU A  85
 None
 0.96A 3l4dA-1dppA:
undetectable		 3l4dA-1dppA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 PHE A  94
ALA A 155
THR A 182
LEU A  85
 None
 1.02A 3l4dD-1dppA:
undetectable		 3l4dD-1dppA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 VAL A 135
VAL A  37
GLY A  49
ALA A  51
LEU A  67
 None
 1.19A 3pghA-1dppA:
0.0		 3pghA-1dppA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 THR A 182
ASP A  89
GLU A 161
 None
 0.71A 3qowA-1dppA:
undetectable		 3qowA-1dppA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 PHE A 344
ALA A 284
THR A 286
LEU A 276
 None
 1.06A 3t3zC-1dppA:
0.0		 3t3zC-1dppA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 ASN A 178
TYR A 162
GLY A 181
THR A 182
 None
 0.85A 3tajA-1dppA:
2.6		 3tajA-1dppA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 ILE A 474
ILE A 381
MET A 402
TRP A 372
 None
 0.80A 3weoA-1dppA:
undetectable		 3weoA-1dppA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 VAL A 504
ILE A 211
GLU A 482
ILE A 254
HIS A 499
 None
 0.99A 4a97B-1dppA:
0.0
4a97C-1dppA:
0.0		 4a97B-1dppA:
18.75
4a97C-1dppA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 175
PHE A  92
PRO A  16
ILE A 157
SER A  93
 None
 1.37A 4b3aA-1dppA:
undetectable		 4b3aA-1dppA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 9 THR A  44
THR A 313
LEU A 496
LEU A 262
GLY A 407
 None
 1.45A 4c9kA-1dppA:
0.0		 4c9kA-1dppA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 4 LEU A 458
ALA A 462
ILE A 443
LYS A 454
 None
 1.38A 4eixA-1dppA:
undetectable		 4eixA-1dppA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A  50
LEU A  36
LEU A 150
ALA A 155
THR A 182
 None
 1.23A 4fn9B-1dppA:
undetectable		 4fn9B-1dppA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 SER A 156
GLY A 497
GLY A  22
GLU A   8
 None
None
LEU  A1002 (-3.8A)
None
 0.84A 4koeA-1dppA:
4.1
4koeB-1dppA:
4.2
4koeD-1dppA:
undetectable		 4koeA-1dppA:
22.70
4koeB-1dppA:
22.70
4koeD-1dppA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 ILE A 475
MET A 351
ARG A 362
 None
 0.79A 4lnwA-1dppA:
0.0		 4lnwA-1dppA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 ILE A 475
MET A 351
ARG A 362
 None
 0.80A 4lnxA-1dppA:
undetectable		 4lnxA-1dppA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 ASP A 149
ASP A 413
SER A 421
PHE A 154
 None
 1.14A 4nedA-1dppA:
4.6		 4nedA-1dppA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 229
HIS A 499
TYR A 491
GLU A 482
 None
 1.05A 4pahA-1dppA:
undetectable		 4pahA-1dppA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 181
ILE A 157
ASN A  34
PRO A  16
GLN A  97
 None
 1.30A 4rtpA-1dppA:
undetectable		 4rtpA-1dppA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 GLY A 497
GLY A  22
GLU A   8
SER A 156
 None
LEU  A1002 (-3.8A)
None
None
 0.82A 4z53A-1dppA:
3.9
4z53B-1dppA:
4.0		 4z53A-1dppA:
21.85
4z53B-1dppA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 THR A 182
ASP A  89
GLU A 161
 None
 0.79A 5fa8A-1dppA:
undetectable		 5fa8A-1dppA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 GLY A 117
PHE A 137
ASN A 414
ASP A 149
 None
 0.91A 5hieD-1dppA:
0.0		 5hieD-1dppA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 VAL A 271
SER A 432
TRP A 434
 None
 0.91A 5jwaA-1dppA:
0.0		 5jwaA-1dppA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 GLY A 183
THR A 182
TYR A 204
ASN A  34
 None
 0.69A 5k4pA-1dppA:
0.0		 5k4pA-1dppA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 ASP A 494
PHE A  39
GLY A 410
GLY A 407
 None
 1.04A 5n9xA-1dppA:
undetectable		 5n9xA-1dppA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 120
LEU A 123
GLN A  97
TYR A 112
 None
 1.37A 5uc3A-1dppA:
0.0		 5uc3A-1dppA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 10 PHE A  19
SER A  21
GLY A  22
ILE A 196
ALA A  27
 None
LEU  A1002 (-4.8A)
LEU  A1002 (-3.8A)
None
None
 1.06A 5zjiA-1dppA:
undetectable
5zjiJ-1dppA:
0.0		 5zjiA-1dppA:
9.88
5zjiJ-1dppA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 124
VAL A  90
VAL A  91
LEU A 120
LEU A 150
 None
 0.87A 6b52A-1dppA:
undetectable		 6b52A-1dppA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1dpp DIPEPTIDE BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 229
HIS A 499
TYR A 491
GLU A 482
 None
 0.94A 6pahA-1dppA:
undetectable		 6pahA-1dppA:
19.80