SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dq3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 12 LEU A 261
ILE A 243
GLY A 245
ALA A 244
LEU A 317
None
0.91A 1cqeA-1dq3A:
undetectable
1cqeA-1dq3A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 12 LEU A 261
ILE A 243
GLY A 245
ALA A 244
LEU A 317
None
0.90A 1cqeB-1dq3A:
undetectable
1cqeB-1dq3A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
6 / 12 VAL A 239
ILE A   9
ILE A  51
ASN A  12
TYR A  28
LEU A 232
None
1.28A 1fm4A-1dq3A:
undetectable
1fm4A-1dq3A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 12 TYR A 185
LEU A 246
HIS A 215
LEU A 219
ILE A 231
None
1.29A 1fmlA-1dq3A:
0.0
1fmlA-1dq3A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 11 ILE A  93
GLY A 448
THR A  91
GLY A 127
GLU A 417
None
1.42A 1i7qA-1dq3A:
3.8
1i7qA-1dq3A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 10 ILE A  93
GLY A 448
THR A  91
GLY A 127
GLU A 417
None
1.38A 1i7qC-1dq3A:
undetectable
1i7qC-1dq3A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 9 ILE A  93
PHE A 101
TYR A 442
ILE A   2
ALA A   6
None
1.27A 1mrgA-1dq3A:
undetectable
1mrgA-1dq3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 12 GLY A 150
ALA A 147
TYR A 216
ASP A 149
ILE A 171
None
1.08A 1nt2A-1dq3A:
0.0
1nt2A-1dq3A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 8 THR A 435
TYR A  52
PHE A  10
GLY A  66
None
1.07A 1ykiC-1dq3A:
undetectable
1ykiD-1dq3A:
undetectable
1ykiC-1dq3A:
18.34
1ykiD-1dq3A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 12 LEU A 261
ILE A 243
GLY A 245
ALA A 244
LEU A 317
None
0.87A 2aylB-1dq3A:
0.0
2aylB-1dq3A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 11 LEU A 330
VAL A 391
ALA A 388
SER A 305
LEU A 307
None
1.24A 2c12F-1dq3A:
0.0
2c12F-1dq3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 7 LEU A 342
PHE A 347
PHE A 108
LEU A 104
None
0.96A 2eimP-1dq3A:
undetectable
2eimW-1dq3A:
undetectable
2eimP-1dq3A:
17.80
2eimW-1dq3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 6 LEU A 186
TYR A 194
ILE A 171
ILE A 212
None
0.88A 2q8hA-1dq3A:
0.0
2q8hA-1dq3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 7 PHE A 247
ILE A 313
ILE A 281
GLY A 262
None
0.98A 2v0mB-1dq3A:
undetectable
2v0mB-1dq3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 6 LEU A 104
ILE A 123
ARG A 384
PRO A 106
None
1.18A 2ygoA-1dq3A:
undetectable
2ygoA-1dq3A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 6 LEU A 342
PHE A 347
PHE A 108
LEU A 104
None
1.01A 3abkP-1dq3A:
undetectable
3abkW-1dq3A:
0.0
3abkP-1dq3A:
17.80
3abkW-1dq3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 6 GLY A 448
GLU A 417
GLY A  90
ASN A 277
None
0.95A 3e9rA-1dq3A:
undetectable
3e9rA-1dq3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 6 GLY A 448
GLU A 417
GLY A  90
ASN A 277
None
0.96A 3e9rC-1dq3A:
undetectable
3e9rC-1dq3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
6 / 12 HIS A  99
LEU A  94
PHE A 431
ILE A   2
GLY A   4
ALA A   6
None
1.49A 3n8xA-1dq3A:
0.0
3n8xA-1dq3A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 11 LEU A 261
ILE A 243
GLY A 245
ALA A 244
LEU A 317
None
1.08A 3n8yA-1dq3A:
0.7
3n8yA-1dq3A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 12 LEU A 261
ILE A 243
GLY A 245
ALA A 244
LEU A 317
None
0.86A 3n8zB-1dq3A:
1.1
3n8zB-1dq3A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 7 LEU A 124
THR A  95
THR A 105
ARG A 114
None
0.94A 3nxuA-1dq3A:
0.0
3nxuA-1dq3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 9 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
None
1.36A 3p4wA-1dq3A:
0.0
3p4wA-1dq3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 12 PHE A  56
GLY A 415
ILE A 413
GLY A 126
PHE A 451
None
1.22A 3ps9A-1dq3A:
2.0
3ps9A-1dq3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 7 ILE A 123
LEU A 340
LEU A 390
VAL A 406
None
0.99A 3r9vA-1dq3A:
1.2
3r9vB-1dq3A:
1.3
3r9vA-1dq3A:
21.64
3r9vB-1dq3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 7 GLU A 399
LEU A 397
GLU A 372
ILE A 369
None
0.96A 3s56B-1dq3A:
0.0
3s56B-1dq3A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
3 / 3 ASN A 211
ALA A 209
ARG A 192
None
0.83A 3tj7C-1dq3A:
0.0
3tj7D-1dq3A:
0.0
3tj7C-1dq3A:
18.40
3tj7D-1dq3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 10 ILE A  93
ASN A 441
TYR A 442
ILE A   2
ALA A   6
None
1.37A 3u6tA-1dq3A:
undetectable
3u6tA-1dq3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 6 LEU A 342
PHE A 347
PHE A 108
LEU A 104
None
1.03A 3wg7P-1dq3A:
undetectable
3wg7W-1dq3A:
0.0
3wg7P-1dq3A:
17.80
3wg7W-1dq3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 12 VAL A 239
ILE A   9
ILE A  51
TYR A  28
LEU A 232
None
1.25A 4a84A-1dq3A:
undetectable
4a84A-1dq3A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 8 ILE A 146
ILE A 182
LEU A 186
ASP A 139
None
0.96A 4dtaB-1dq3A:
undetectable
4dtaB-1dq3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 8 GLU A 320
GLU A 321
GLY A 314
ARG A 323
None
0.97A 4fgzA-1dq3A:
undetectable
4fgzB-1dq3A:
undetectable
4fgzA-1dq3A:
22.37
4fgzB-1dq3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 12 GLY A 148
GLY A 150
LEU A 220
MET A 263
LEU A 246
None
1.24A 4x61A-1dq3A:
0.0
4x61A-1dq3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 9 ILE A  93
PHE A 101
TYR A 442
ILE A   2
ALA A   6
None
1.30A 4yp2B-1dq3A:
undetectable
4yp2B-1dq3A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 7 ARG A 170
ARG A 200
ILE A 202
TYR A 172
None
1.37A 5a06B-1dq3A:
0.0
5a06B-1dq3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 9 ILE A  93
PHE A 101
TYR A 442
ILE A   2
ALA A   6
None
1.29A 5cf9B-1dq3A:
undetectable
5cf9B-1dq3A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 12 LEU A 376
TRP A 379
PHE A 108
ALA A 351
LEU A 397
None
1.17A 5iepA-1dq3A:
0.3
5iepA-1dq3A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 9 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
None
1.31A 5mvnB-1dq3A:
0.0
5mvnB-1dq3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 10 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
None
1.29A 5mvnD-1dq3A:
0.0
5mvnD-1dq3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 10 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
None
1.24A 5mzrA-1dq3A:
0.0
5mzrA-1dq3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 10 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
None
1.23A 5mzrC-1dq3A:
0.0
5mzrC-1dq3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 9 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
None
1.24A 5mzrD-1dq3A:
0.0
5mzrD-1dq3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
4 / 5 LEU A 342
PHE A 347
PHE A 108
LEU A 104
None
1.05A 5x1bP-1dq3A:
0.0
5x1bP-1dq3A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)
1dq3 ENDONUCLEASE
(Pyrococcus
furiosus)
5 / 11 PHE A 242
ILE A 243
LEU A 246
LEU A 219
PRO A 228
None
1.40A 6fgcA-1dq3A:
undetectable
6fgcA-1dq3A:
10.89