SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dql'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1dql IGM MEZ
IMMUNOGLOBULIN
(Homo
sapiens) 		4 / 8 TYR L  36
TYR L  49
LEU L  89
TRP L  95
 None
 0.69A 1i7zA-1dqlL:
20.2		 1i7zA-1dqlL:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1dql IGM MEZ
IMMUNOGLOBULIN
(Homo
sapiens) 		5 / 10 TRP H  47
TYR H  59
GLY H  99
GLY H 110
TRP H 113
 None
 0.67A 3ls4H-1dqlH:
22.5		 3ls4H-1dqlH:
67.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1dql IGM MEZ
IMMUNOGLOBULIN
(Homo
sapiens) 		4 / 6 GLN L  37
TYR L  86
GLN L   6
ILE L  21
 None
 1.27A 3peoG-1dqlL:
1.4		 3peoG-1dqlL:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1dql IGM MEZ
IMMUNOGLOBULIN
(Homo
sapiens) 		4 / 6 GLN L  90
MET L   4
ILE L  29
SER H 105
 None
 1.34A 3pmzD-1dqlL:
1.3		 3pmzD-1dqlL:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1dql IGM MEZ
IMMUNOGLOBULIN
(Homo
sapiens) 		5 / 12 PHE L  83
GLN L  37
LEU L  73
VAL L  19
ILE L  75
 None
 1.21A 4k38B-1dqlL:
undetectable		 4k38B-1dqlL:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1dql IGM MEZ
IMMUNOGLOBULIN
(Homo
sapiens) 		3 / 3 ASN H 100
ASP H  54
GLY H  55
 None
 0.63A 5fctB-1dqlH:
undetectable		 5fctB-1dqlH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 1dql IGM MEZ
IMMUNOGLOBULIN
(Homo
sapiens) 		4 / 8 THR L  74
SER L  63
THR L  72
SER L  65
 None
 0.99A 5l4eA-1dqlL:
2.2
5l4eB-1dqlL:
2.2
5l4eC-1dqlL:
2.1
5l4eD-1dqlL:
2.3
5l4eE-1dqlL:
2.2		 5l4eA-1dqlL:
15.14
5l4eB-1dqlL:
15.14
5l4eC-1dqlL:
15.14
5l4eD-1dqlL:
15.14
5l4eE-1dqlL:
15.14