SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dqp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 7 PHE A 150
ALA A  36
ILE A 219
GLU A  40
 None
 1.15A 1oniA-1dqpA:
undetectable
1oniB-1dqpA:
undetectable		 1oniA-1dqpA:
18.47
1oniB-1dqpA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 5 TYR A 172
GLU A  40
PHE A 211
ALA A  36
 None
 1.27A 1oniE-1dqpA:
0.5
1oniF-1dqpA:
0.5		 1oniE-1dqpA:
18.47
1oniF-1dqpA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 7 ILE A 219
GLU A  40
PHE A 150
ALA A  36
 None
 1.11A 1oniG-1dqpA:
undetectable
1oniI-1dqpA:
undetectable		 1oniG-1dqpA:
18.47
1oniI-1dqpA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 7 THR A  88
VAL A  66
THR A  64
VAL A 121
 None
 0.56A 3em0B-1dqpA:
undetectable		 3em0B-1dqpA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 7 ILE A 182
GLY A 183
PHE A  18
PHE A  17
 None
 0.74A 3v7pA-1dqpA:
0.2		 3v7pA-1dqpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		5 / 12 LEU A  74
LEU A  44
CYH A 149
PHE A 150
ASP A 200
 None
 1.23A 4j7xJ-1dqpA:
undetectable		 4j7xJ-1dqpA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		4 / 7 ILE A 137
PHE A 107
LEU A  68
THR A  64
 None
 1.03A 4mmcA-1dqpA:
0.0		 4mmcA-1dqpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		5 / 12 GLY A 185
GLY A 194
ASP A 125
ALA A  45
THR A  48
 None
 1.09A 4uckB-1dqpA:
2.5		 4uckB-1dqpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		5 / 12 LEU A 222
GLY A 171
CYH A 149
LEU A 215
SER A   4
 None
 1.17A 4zbrA-1dqpA:
undetectable		 4zbrA-1dqpA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		5 / 12 GLY A   7
LEU A 215
GLY A 171
LEU A 222
THR A   6
 None
 1.32A 4ze1A-1dqpA:
0.0		 4ze1A-1dqpA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		5 / 11 VAL A  92
VAL A  94
ILE A 146
ILE A 137
LEU A 115
 None
 1.00A 5e4dB-1dqpA:
0.0		 5e4dB-1dqpA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Giardia
intestinalis) 		3 / 3 LYS A   8
PRO A   9
LYS A  11
 None
 0.84A 5y9yA-1dqpA:
0.0		 5y9yA-1dqpA:
22.46