SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dqu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ALA A 192
PRO A 164
THR A  93
VAL A 127
LEU A  63
 None
 1.24A 1cbrA-1dquA:
undetectable		 1cbrA-1dquA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ALA A 192
PRO A 164
THR A  93
VAL A 127
LEU A  63
 None
 1.24A 1cbrB-1dquA:
undetectable		 1cbrB-1dquA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 0.96A 1fbyA-1dquA:
undetectable		 1fbyA-1dquA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 0.96A 1fbyB-1dquA:
undetectable		 1fbyB-1dquA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 0.98A 1fm6A-1dquA:
undetectable		 1fm6A-1dquA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 6 LYS A  47
VAL A 187
ILE A  48
ARG A  26
 None
 1.13A 1iepA-1dquA:
undetectable		 1iepA-1dquA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 8 THR A 104
GLY A  77
LEU A  79
SER A  97
GLY A 460
 None
 1.45A 1jhqA-1dquA:
0.3		 1jhqA-1dquA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		3 / 3 ASP A 400
TYR A 401
GLU A 438
 None
 0.76A 1vm1A-1dquA:
1.1		 1vm1A-1dquA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 0.96A 1xdkE-1dquA:
undetectable		 1xdkE-1dquA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 0.99A 1xiuA-1dquA:
undetectable		 1xiuA-1dquA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		3 / 3 THR A  82
GLU A 491
HIS A 501
 None
 0.91A 1xwfA-1dquA:
0.0		 1xwfA-1dquA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		3 / 3 THR A  82
GLU A 491
HIS A 501
 None
 0.91A 1xwfB-1dquA:
0.0		 1xwfB-1dquA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		3 / 3 THR A  82
GLU A 491
HIS A 501
 None
 0.90A 1xwfD-1dquA:
0.0		 1xwfD-1dquA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ALA A 404
GLN A 403
SER A 396
LEU A 398
MET A 434
 None
 1.19A 2aa5A-1dquA:
undetectable		 2aa5A-1dquA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 0.97A 2aclG-1dquA:
undetectable		 2aclG-1dquA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 6 ASP A 237
ARG A  26
THR A  30
ASP A 390
 None
 1.10A 2j2pE-1dquA:
undetectable
2j2pF-1dquA:
undetectable		 2j2pE-1dquA:
16.57
2j2pF-1dquA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_B_NIOB1216_1
(NICOTINAMIDASE)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 9 ASP A 168
LEU A 182
ASP A 170
HIS A 173
ALA A 167
 None
 1.38A 2wt9B-1dquA:
undetectable		 2wt9B-1dquA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 8 THR A 244
ILE A 392
ASP A 198
SER A 246
 None
 1.09A 2xytE-1dquA:
undetectable		 2xytE-1dquA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 8 THR A 244
ILE A 392
ASP A 198
SER A 246
 None
 1.00A 2xytH-1dquA:
0.0		 2xytH-1dquA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 7 THR A 244
ILE A 392
ASP A 198
SER A 246
 None
 1.00A 2xytI-1dquA:
undetectable		 2xytI-1dquA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 GLY A 172
GLY A 175
LEU A 176
LEU A 238
ALA A 178
 None
 1.01A 3av6A-1dquA:
undetectable		 3av6A-1dquA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 8 SER A 101
THR A 122
VAL A 123
ALA A 116
 None
 0.91A 3ax7A-1dquA:
0.0		 3ax7A-1dquA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 8 SER A 101
THR A 122
VAL A 123
ALA A 116
 None
 0.97A 3ax9A-1dquA:
0.0		 3ax9A-1dquA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 10 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 0.94A 3falC-1dquA:
undetectable		 3falC-1dquA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 11 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 0.92A 3fc6A-1dquA:
undetectable		 3fc6A-1dquA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 6 SER A 101
ASP A 170
TYR A 118
PRO A 113
 None
 1.48A 3jqaC-1dquA:
2.1		 3jqaC-1dquA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 6 SER A 101
ASP A 170
TYR A 118
PRO A 113
 None
 1.48A 3jqaD-1dquA:
2.0		 3jqaD-1dquA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 5 LYS A  47
VAL A 187
ILE A  48
ARG A  26
 None
 1.37A 3oezA-1dquA:
undetectable		 3oezA-1dquA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 5 LYS A  47
VAL A 187
ILE A  48
ARG A  26
 None
 1.44A 3pyyB-1dquA:
undetectable		 3pyyB-1dquA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_A_NIOA311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 9 ASP A 168
LEU A 182
ASP A 170
HIS A 173
ALA A 167
 None
 1.28A 3r2jA-1dquA:
undetectable		 3r2jA-1dquA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 11 ASP A 168
LEU A 182
ASP A 170
HIS A 173
ALA A 167
 None
 1.32A 3r2jB-1dquA:
undetectable		 3r2jB-1dquA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ASP A 168
LEU A 182
ASP A 170
HIS A 173
ALA A 167
 None
 1.30A 3r2jC-1dquA:
undetectable		 3r2jC-1dquA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 11 ASP A 168
LEU A 182
ASP A 170
HIS A 173
ALA A 167
 None
 1.31A 3r2jD-1dquA:
undetectable		 3r2jD-1dquA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 8 ALA A 507
VAL A 510
ASP A 511
LEU A 514
 None
 0.41A 3roxA-1dquA:
undetectable		 3roxA-1dquA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 0.95A 4k6iA-1dquA:
undetectable		 4k6iA-1dquA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 8 ASP A 198
ASP A 245
GLU A 247
TYR A 422
 None
 0.98A 4xjeA-1dquA:
0.0		 4xjeA-1dquA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 9 ALA A 303
LEU A 275
LEU A 278
ILE A 295
 None
 0.94A 4xtaA-1dquA:
0.5		 4xtaA-1dquA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 6 VAL A 127
LEU A 238
ILE A 194
ALA A 167
 None
 0.66A 4zf8A-1dquA:
0.0		 4zf8A-1dquA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 7 PHE A  34
ARG A  32
ASP A 232
ILE A  39
 None
 1.38A 5a06B-1dquA:
1.4		 5a06B-1dquA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 8 ASP A 198
ASP A 245
GLU A 247
TYR A 422
 None
 1.07A 5cfsA-1dquA:
0.0		 5cfsA-1dquA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		4 / 8 ILE A 316
LYS A 325
VAL A 313
GLU A 329
 None
 0.98A 5dqyA-1dquA:
0.0		 5dqyA-1dquA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 0.96A 5uanA-1dquA:
undetectable		 5uanA-1dquA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1dqu ISOCITRATE LYASE
(Aspergillus
nidulans) 		5 / 12 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
 None
 1.01A 5z12C-1dquA:
undetectable		 5z12C-1dquA:
9.30