SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  51
GLY A 236
VAL A 220
ILE A 232
ILE A  55
 None
 1.02A 3ebzB-1dqwA:
undetectable		 3ebzB-1dqwA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 CYH A  33
PRO A 202
ASP A  91
 None
 0.94A 3hlwB-1dqwA:
0.0		 3hlwB-1dqwA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  13
GLY A 181
ILE A 180
 None
 0.64A 4k50A-1dqwA:
0.0		 4k50A-1dqwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  13
GLY A 181
ILE A 180
 None
 0.61A 4k50I-1dqwA:
undetectable		 4k50I-1dqwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 205
ASP A 207
GLY A 236
GLU A 247
 None
 0.93A 4koeA-1dqwA:
undetectable
4koeB-1dqwA:
undetectable
4koeD-1dqwA:
undetectable		 4koeA-1dqwA:
21.16
4koeB-1dqwA:
21.16
4koeD-1dqwA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 CYH A  33
PRO A 202
ASP A  91
 None
 0.98A 4pm5A-1dqwA:
undetectable		 4pm5A-1dqwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 220
TYR A 251
ALA A 254
 None
 0.42A 4ybnA-1dqwA:
0.0		 4ybnA-1dqwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 239
PHE A 238
GLY A 236
ALA A 212
GLY A 214
 None
 1.28A 4zjzB-1dqwA:
undetectable		 4zjzB-1dqwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 7 GLY A 203
GLY A 214
GLY A 234
VAL A 204
LEU A 237
 None
 1.37A 5izjB-1dqwA:
undetectable		 5izjB-1dqwA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 169
ILE A 183
SER A 160
THR A 165
 None
 0.83A 5vkqA-1dqwA:
0.0
5vkqD-1dqwA:
0.0		 5vkqA-1dqwA:
10.06
5vkqD-1dqwA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  65
SER A  81
LYS A  78
ASP A 117
ASP A  91
 None
 1.50A 6bxlA-1dqwA:
0.0		 6bxlA-1dqwA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  98
SER A 131
GLY A 132
VAL A 101
 None
 0.97A 6ekzA-1dqwA:
0.0		 6ekzA-1dqwA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  67
ASP A  63
ASN A 120
 None
 0.80A 6gngB-1dqwA:
undetectable		 6gngB-1dqwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 181
LEU A 198
ASP A 170
ILE A 171
VAL A  17
 None
 1.02A 6mhtA-1dqwA:
undetectable		 6mhtA-1dqwA:
24.04