SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 118
PHE A  26
VAL A 113
 None
 0.80A 1kijA-1dqzA:
0.0		 1kijA-1dqzA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		5 / 12 ASN A  52
ILE A  51
GLY A  39
SER A 126
PHE A 150
 None
 1.28A 1q8jA-1dqzA:
undetectable		 1q8jA-1dqzA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 144
GLY A 127
GLY A 128
ILE A 132
ILE A 205
 None
 0.98A 1sduA-1dqzA:
undetectable		 1sduA-1dqzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		5 / 8 GLY A 122
GLY A 127
GLY A 128
LEU A 151
ILE A 205
 None
 0.95A 1yajC-1dqzA:
6.0		 1yajC-1dqzA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 172
TYR A  93
ASP A  38
ASP A  50
 None
 1.03A 2g72B-1dqzA:
undetectable		 2g72B-1dqzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 242
ILE A 195
LEU A 151
LEU A 131
 None
 1.15A 2zb7A-1dqzA:
2.6		 2zb7A-1dqzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		3 / 3 PRO A  69
GLU A  96
TYR A  77
 None
 0.74A 2zmbA-1dqzA:
0.0		 2zmbA-1dqzA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 270
LYS A 273
ILE A 276
GLN A 277
 None
 0.71A 3bjwB-1dqzA:
undetectable		 3bjwB-1dqzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 185
ASN A 189
PRO A 153
PRO A 159
 None
 0.69A 3fxrA-1dqzA:
0.0		 3fxrA-1dqzA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 128
GLY A 149
LEU A 269
MET A 272
ALA A 119
 None
 1.14A 3t7vA-1dqzA:
undetectable		 3t7vA-1dqzA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		5 / 9 GLY A 219
ALA A 224
GLY A 218
LEU A 217
SER A 215
 None
 1.28A 5vw4A-1dqzA:
undetectable		 5vw4A-1dqzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 188
ARG A 197
ALA A 120
GLN A 194
 None
 0.96A 6b89B-1dqzA:
undetectable		 6b89B-1dqzA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1dqz PROTEIN (ANTIGEN
85-C)
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 198
GLY A 250
PHE A 254
 None
 0.66A 6exiC-1dqzA:
4.1		 6exiC-1dqzA:
13.64