SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1drk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 VAL A 245
GLY A 244
ALA A  23
LEU A  34
 None
 0.71A 1e7bB-1drkA:
undetectable		 1e7bB-1drkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 129
ARG A 141
PHE A 145
GLY A 109
 None
RIP  A 272 ( 2.6A)
None
None
 1.00A 1fapB-1drkA:
undetectable		 1fapB-1drkA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 ASP A 249
LEU A  62
ALA A  27
LEU A  30
 None
 1.10A 1nh8A-1drkA:
1.5		 1nh8A-1drkA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 10 THR A 135
GLU A 140
HIS A 100
ALA A  92
THR A  93
 None
 0.81A 1r55A-1drkA:
3.5		 1r55A-1drkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 VAL A   7
LEU A   6
ILE A  60
SER A  99
THR A  87
 None
 1.26A 3bjwE-1drkA:
undetectable		 3bjwE-1drkA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 VAL A   7
LEU A   6
ILE A  60
SER A  99
THR A  87
 None
 1.31A 3bjwH-1drkA:
0.1		 3bjwH-1drkA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 PRO A 161
PHE A 164
ALA A 138
 None
RIP  A 272 ( 2.8A)
None
 0.65A 3itaD-1drkA:
0.0		 3itaD-1drkA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  63
ALA A  48
ALA A  70
VAL A  71
ASN A  73
 None
 1.07A 3jb3A-1drkA:
0.0		 3jb3A-1drkA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 9 ALA A  78
ILE A  63
VAL A  71
GLY A  95
ILE A  86
 None
 1.00A 3s43A-1drkA:
undetectable		 3s43A-1drkA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 LYS A 260
SER A 136
GLN A  91
 None
 1.35A 3si7A-1drkA:
undetectable		 3si7A-1drkA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 PHE A 187
GLY A 109
GLY A 113
ALA A 148
GLY A 144
 None
 0.97A 3tegA-1drkA:
undetectable		 3tegA-1drkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 SER A 136
THR A  87
VAL A  71
ASP A  69
 None
 1.12A 4eohA-1drkA:
2.6		 4eohA-1drkA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 201
LEU A 198
LEU A 195
ALA A 194
ALA A 231
 None
 1.10A 4fn9A-1drkA:
undetectable		 4fn9A-1drkA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 VAL A 251
GLY A 254
LYS A 256
 None
 0.74A 4k50A-1drkA:
undetectable		 4k50A-1drkA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 VAL A 251
GLY A 254
LYS A 256
 None
 0.74A 4k50E-1drkA:
0.0		 4k50E-1drkA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 VAL A 251
GLY A 254
LYS A 256
 None
 0.76A 4k50I-1drkA:
0.0		 4k50I-1drkA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 198
LEU A 195
GLY A 196
LEU A 129
VAL A 212
 None
 1.33A 4olmA-1drkA:
undetectable		 4olmA-1drkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 GLN A  91
HIS A 100
GLU A 140
ARG A  90
 None
None
None
RIP  A 272 ( 3.9A)
 1.40A 4qyqC-1drkA:
undetectable		 4qyqC-1drkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 ALA A  27
ILE A 101
SER A  99
ASP A 249
GLN A 258
 None
 1.26A 4rtpA-1drkA:
3.4		 4rtpA-1drkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 8 ALA A  81
ALA A  78
ILE A  83
ALA A  48
LEU A  53
 None
 1.42A 4v1fA-1drkA:
undetectable
4v1fB-1drkA:
undetectable		 4v1fA-1drkA:
13.65
4v1fB-1drkA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 236
ASP A 215
GLU A 221
PRO A  14
 None
RIP  A 272 ( 2.6A)
None
None
 1.09A 4xi3C-1drkA:
0.0		 4xi3C-1drkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 LEU A 198
ARG A 166
ARG A 199
 None
 0.94A 4yiaB-1drkA:
0.0		 4yiaB-1drkA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 GLN A  91
HIS A 100
GLU A 140
ARG A  90
 None
None
None
RIP  A 272 ( 3.9A)
 1.40A 5hpwC-1drkA:
undetectable		 5hpwC-1drkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 4 THR A 132
THR A 135
ALA A 138
ARG A  90
 None
None
None
RIP  A 272 ( 3.9A)
 1.35A 5wm7A-1drkA:
5.0		 5wm7A-1drkA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 THR A 135
PHE A  16
PHE A  15
ASN A  13
ASN A  64
 None
RIP  A 272 ( 3.6A)
RIP  A 272 ( 2.6A)
RIP  A 272 ( 2.8A)
None
 1.26A 6h7jB-1drkA:
undetectable		 6h7jB-1drkA:
15.36