SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1drt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		5 / 12 LEU A  46
GLY A  57
ALA A  49
LEU A  50
ASP A  60
 None
 0.87A 1bx4A-1drtA:
undetectable		 1bx4A-1drtA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		3 / 3 LEU A 270
LEU A  64
SER A   3
 None
 0.63A 1tlmA-1drtA:
0.0		 1tlmA-1drtA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		5 / 12 LEU A 141
ALA A 171
LEU A 270
LEU A 295
THR A 136
 AKG  A 326 (-4.7A)
None
None
None
None
 1.34A 1ya3B-1drtA:
undetectable		 1ya3B-1drtA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		4 / 5 LEU A  46
LEU A  63
LEU A  64
LEU A  50
 None
 1.15A 1yajD-1drtA:
undetectable		 1yajD-1drtA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		5 / 11 LEU A  42
LEU A  16
LEU A 100
ARG A 104
ARG A 103
 None
 1.12A 2ceoA-1drtA:
0.0		 2ceoA-1drtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		4 / 7 PHE A 229
ARG A 178
ARG A 304
ASP A 227
 None
 1.12A 2e5dA-1drtA:
undetectable
2e5dB-1drtA:
0.0		 2e5dA-1drtA:
22.53
2e5dB-1drtA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		4 / 7 ASP A 227
PHE A 229
ARG A 178
ARG A 304
 None
 1.03A 2e5dA-1drtA:
undetectable
2e5dB-1drtA:
undetectable		 2e5dA-1drtA:
22.53
2e5dB-1drtA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		5 / 12 LEU A 141
ALA A 171
LEU A 270
LEU A 295
THR A 136
 AKG  A 326 (-4.7A)
None
None
None
None
 1.30A 2oaxB-1drtA:
undetectable		 2oaxB-1drtA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		5 / 12 LEU A 141
ALA A 171
LEU A 270
LEU A 295
THR A 136
 AKG  A 326 (-4.7A)
None
None
None
None
 1.31A 2oaxC-1drtA:
undetectable		 2oaxC-1drtA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		5 / 12 LEU A 173
PHE A 143
LEU A 295
VAL A 123
VAL A 272
 None
 1.29A 2qd4A-1drtA:
undetectable		 2qd4A-1drtA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		6 / 10 LEU A  42
LEU A  16
LEU A  20
LEU A 100
ARG A 104
ARG A 103
 None
 1.35A 2xn6A-1drtA:
0.0
2xn6B-1drtA:
0.0		 2xn6A-1drtA:
21.58
2xn6B-1drtA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		6 / 10 LEU A  42
LEU A  16
LEU A  20
LEU A 100
ARG A 104
ARG A 103
 None
 1.38A 2xn7A-1drtA:
0.0
2xn7B-1drtA:
0.0		 2xn7A-1drtA:
21.15
2xn7B-1drtA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		4 / 8 THR A 172
ARG A  66
ASP A 165
GLU A 265
 AKG  A 326 (-3.0A)
None
None
None
 1.07A 2zw9A-1drtA:
2.8		 2zw9A-1drtA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		3 / 3 ARG A 276
ASP A  60
ASP A 273
 None
 0.69A 3jayA-1drtA:
0.0		 3jayA-1drtA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		3 / 3 ARG A 276
ASP A  60
ASP A 273
 None
 0.72A 3jb3A-1drtA:
0.0		 3jb3A-1drtA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		4 / 5 HIS A 108
LEU A 270
LEU A  63
ASP A 268
 None
 1.30A 4aqlA-1drtA:
undetectable		 4aqlA-1drtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		3 / 3 GLU A 135
TYR A 124
SER A  81
 None
 0.96A 4at0A-1drtA:
0.0		 4at0A-1drtA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		3 / 3 ASN A 274
LEU A 255
PHE A 229
 None
 0.73A 4dajB-1drtA:
0.0		 4dajB-1drtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		5 / 10 ASP A  51
LEU A  46
LEU A  65
ILE A 271
LEU A  63
 None
 0.94A 4odoA-1drtA:
undetectable		 4odoA-1drtA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		5 / 10 ASP A  51
LEU A  46
LEU A  65
ILE A 271
LEU A  63
 None
 0.99A 4odoB-1drtA:
undetectable		 4odoB-1drtA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		3 / 3 LEU A 159
MET A  94
TYR A 124
 AKG  A 326 (-4.9A)
None
None
 0.78A 4p6xG-1drtA:
undetectable		 4p6xG-1drtA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		4 / 8 GLU A  95
LEU A  13
LEU A  20
GLY A 102
 None
 0.86A 4r3aA-1drtA:
undetectable		 4r3aA-1drtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		5 / 12 LEU A  46
GLY A  57
ALA A  49
LEU A  50
ASP A  60
 None
 0.91A 5kb5A-1drtA:
undetectable		 5kb5A-1drtA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		3 / 3 GLU A 146
ARG A 297
TYR A 299
 FE2  A 325 (-2.4A)
PCV  A 327 ( 2.9A)
None
 0.63A 5trqB-1drtA:
9.7		 5trqB-1drtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		4 / 8 VAL A   4
ASP A   5
GLY A  10
LEU A  13
 None
 0.87A 5w3jB-1drtA:
undetectable		 5w3jB-1drtA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		5 / 12 LEU A 237
ASP A 244
ARG A 323
PRO A 228
GLY A 223
 None
 0.96A 6b0lB-1drtA:
0.0		 6b0lB-1drtA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1drt CLAVAMINATE SYNTHASE
1
(Streptomyces
clavuligerus) 		4 / 7 TYR A 120
GLY A  99
ARG A 281
ALA A 160
 None
 0.81A 6hd6B-1drtA:
undetectable		 6hd6B-1drtA:
14.00