SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		4 / 7 THR A  26
ASN A  31
TYR A  36
LEU A 153
 None
 0.99A 1qzrA-1dt2A:
undetectable		 1qzrA-1dt2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		4 / 8 LEU A 152
ILE A 169
ILE A 200
HIS A 201
 None
 0.95A 2azxA-1dt2A:
undetectable		 2azxA-1dt2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		5 / 11 ALA A 116
THR A  62
ILE A 104
ALA A  70
VAL A  42
 None
 1.11A 2qhfA-1dt2A:
0.0		 2qhfA-1dt2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		4 / 8 HIS A  27
SER A 163
ASN A  84
ASP A  86
 None
 1.06A 2v57A-1dt2A:
undetectable		 2v57A-1dt2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		4 / 8 HIS A  27
SER A 163
ASN A  84
ASP A  86
 None
 1.07A 2v57C-1dt2A:
undetectable		 2v57C-1dt2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		5 / 12 ALA A  50
GLY A 187
GLY A  52
ASN A  63
VAL A  66
 None
 1.20A 3f8wC-1dt2A:
undetectable		 3f8wC-1dt2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		4 / 4 LYS A  14
GLN A 207
ILE A 212
LEU A 152
 None
 1.41A 3qt0A-1dt2A:
0.0		 3qt0A-1dt2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		5 / 11 TYR A  64
HIS A  65
ASP A 114
GLY A 184
SER A 186
 None
 1.10A 3sufC-1dt2A:
9.9		 3sufC-1dt2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		5 / 12 LEU A 234
LEU A 115
ASN A  63
ILE A  55
ILE A 117
 None
 1.11A 3ut5B-1dt2A:
undetectable		 3ut5B-1dt2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		5 / 9 LEU A 152
LEU A 153
GLY A 154
THR A  51
VAL A  53
 None
 1.45A 4c9kB-1dt2A:
undetectable		 4c9kB-1dt2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		4 / 8 LEU A 234
ILE A  55
VAL A  53
GLY A 199
 None
 0.71A 4eq4B-1dt2A:
undetectable		 4eq4B-1dt2A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		4 / 8 GLU A 106
GLN A 111
GLY A 110
SER A 107
 None
 0.99A 4f93B-1dt2A:
undetectable		 4f93B-1dt2A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		5 / 12 GLY A  52
GLY A 189
ILE A  55
VAL A  42
VAL A  66
 None
 0.95A 4gc9A-1dt2A:
undetectable		 4gc9A-1dt2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		3 / 3 GLY A 154
GLU A 182
THR A 181
 None
 0.47A 4kouA-1dt2A:
0.0		 4kouA-1dt2A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		3 / 3 VAL A  39
ALA A  82
PHE A  79
 None
 0.79A 4olbA-1dt2A:
undetectable		 4olbA-1dt2A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		3 / 3 VAL A  39
ALA A  82
PHE A  79
 None
 0.84A 4w5nA-1dt2A:
0.0		 4w5nA-1dt2A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		5 / 12 LEU A 234
LEU A 115
ASN A  63
ILE A  55
ILE A 117
 None
 1.06A 5itzB-1dt2A:
0.0		 5itzB-1dt2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		4 / 5 ILE A 144
LEU A 238
GLY A 235
PHE A 216
 None
 0.84A 5kmdC-1dt2A:
undetectable
5kmdD-1dt2A:
undetectable		 5kmdC-1dt2A:
22.22
5kmdD-1dt2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 1dt2 EXFOLIATIVE TOXIN B
(Staphylococcus
aureus) 		5 / 12 ILE A 138
PHE A 216
LEU A  54
VAL A  61
SER A  38
 None
 1.25A 5l8oB-1dt2A:
0.0		 5l8oB-1dt2A:
20.24