SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dtd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 11 HIS A 424
ILE A 550
ASP A 612
GLY A 609
TYR A 562
 ZN  A 301 ( 3.4A)
None
None
None
None
 1.45A 1axwB-1dtdA:
0.0		 1axwB-1dtdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 4 THR A 410
LEU A 388
VAL A 389
LEU A 381
 None
 0.87A 1mz9D-1dtdA:
undetectable		 1mz9D-1dtdA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		3 / 3 THR A 433
GLU A 427
ASP A 498
 None
ZN  A 301 (-2.6A)
GLU  A 300 ( 4.5A)
 0.84A 1nt2A-1dtdA:
undetectable		 1nt2A-1dtdA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 1dtd CARBOXYPEPTIDASE A2
METALLOCARBOXYPEPTID
ASE INHIBITOR
(Homo
sapiens;
Hirudo
medicinalis) 		5 / 12 PRO B  64
GLY A 422
ASN A 500
ASP A 498
VAL B  17
 None
None
GLU  A 300 (-3.4A)
GLU  A 300 ( 4.5A)
None
 1.17A 1r30A-1dtdB:
undetectable		 1r30A-1dtdB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR
(Hirudo
medicinalis) 		4 / 8 PHE B  20
GLU B  31
GLN B  13
TRP B  42
 None
 1.48A 2aoxA-1dtdB:
undetectable		 2aoxA-1dtdB:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR
(Hirudo
medicinalis) 		4 / 7 PHE B  20
GLU B  31
GLN B  13
TRP B  42
 None
 1.47A 2aoxB-1dtdB:
undetectable		 2aoxB-1dtdB:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 7 SER A 555
SER A 553
PHE A 635
GLU A 626
 None
None
None
GLU  A 300 (-4.2A)
 1.17A 2c8aA-1dtdA:
undetectable		 2c8aA-1dtdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 7 GLY A 634
SER A 555
SER A 553
PHE A 635
GLU A 626
 None
None
None
None
GLU  A 300 (-4.2A)
 1.27A 2c8aB-1dtdA:
undetectable		 2c8aB-1dtdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 6 SER A 555
SER A 553
PHE A 635
GLU A 626
 None
None
None
GLU  A 300 (-4.2A)
 1.23A 2c8aC-1dtdA:
undetectable		 2c8aC-1dtdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 7 GLY A 634
SER A 555
SER A 553
PHE A 635
GLU A 626
 None
None
None
None
GLU  A 300 (-4.2A)
 1.30A 2c8aD-1dtdA:
undetectable		 2c8aD-1dtdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 8 ASP A 519
SER A 520
SER A 513
ASN A 515
 None
 1.12A 2cmlB-1dtdA:
undetectable		 2cmlB-1dtdA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 5 SER A 553
LEU A 636
GLY A 634
ARG A 479
 None
 0.95A 2j2pA-1dtdA:
0.0
2j2pB-1dtdA:
0.0		 2j2pA-1dtdA:
19.62
2j2pB-1dtdA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 6 ARG A 479
SER A 553
LEU A 636
GLY A 634
 None
 1.03A 2j2pA-1dtdA:
0.0
2j2pC-1dtdA:
0.0		 2j2pA-1dtdA:
19.62
2j2pC-1dtdA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 6 ARG A 479
SER A 553
LEU A 636
GLY A 634
 None
 1.01A 2j2pD-1dtdA:
0.0
2j2pF-1dtdA:
0.0		 2j2pD-1dtdA:
19.62
2j2pF-1dtdA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 THR A 430
ALA A 434
LEU A 435
LEU A 462
ILE A 535
 None
 1.12A 2jfaA-1dtdA:
undetectable		 2jfaA-1dtdA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 9 LEU A 462
ILE A 460
ILE A 441
ALA A 434
LEU A 419
 None
 1.15A 2m9qA-1dtdA:
0.0		 2m9qA-1dtdA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 THR A 430
ALA A 434
LEU A 435
LEU A 462
ILE A 535
 None
 1.07A 2qxsA-1dtdA:
undetectable		 2qxsA-1dtdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 THR A 430
ALA A 434
LEU A 435
LEU A 462
ILE A 535
 None
 1.10A 2qxsB-1dtdA:
undetectable		 2qxsB-1dtdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 10 VAL A 536
SER A 614
SER A 622
GLY A 608
ALA A 505
 None
 1.29A 2x2iB-1dtdA:
0.0		 2x2iB-1dtdA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		3 / 3 GLU A 626
HIS A 424
GLU A 427
 GLU  A 300 (-4.2A)
ZN  A 301 ( 3.4A)
ZN  A 301 (-2.6A)
 0.82A 2x45B-1dtdA:
0.0		 2x45B-1dtdA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		3 / 3 GLU A 626
HIS A 424
GLU A 427
 GLU  A 300 (-4.2A)
ZN  A 301 ( 3.4A)
ZN  A 301 (-2.6A)
 0.84A 2x45C-1dtdA:
0.0		 2x45C-1dtdA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 7 ILE A 417
TYR A 665
VAL A 545
TYR A 621
 None
 1.37A 2xz5D-1dtdA:
undetectable
2xz5E-1dtdA:
undetectable		 2xz5D-1dtdA:
21.59
2xz5E-1dtdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 6 THR A 645
THR A 649
LEU A 551
THR A 433
 None
 0.73A 3deuB-1dtdA:
0.0		 3deuB-1dtdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 ILE A 374
VAL A 472
MET A 403
PRO A 402
SER A 397
 None
 1.06A 3iw1A-1dtdA:
0.0		 3iw1A-1dtdA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 LEU A 435
ALA A 434
LEU A 462
ILE A 451
LEU A 653
 None
 1.07A 3q95B-1dtdA:
undetectable		 3q95B-1dtdA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 ILE A 549
PHE A 625
ILE A 417
ALA A 547
VAL A 578
 None
 1.26A 3s79A-1dtdA:
undetectable		 3s79A-1dtdA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 5 THR A 484
GLY A 470
PRO A 468
ASN A 467
 None
 0.87A 3u8qA-1dtdA:
undetectable		 3u8qA-1dtdA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 5 LEU A 551
LEU A 419
MET A 657
THR A 437
 None
 1.09A 4do3A-1dtdA:
0.4		 4do3A-1dtdA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 6 LEU A 551
LEU A 419
ILE A 460
MET A 657
THR A 437
 None
 1.28A 4do3B-1dtdA:
undetectable		 4do3B-1dtdA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 6 THR A 484
GLY A 470
PRO A 468
ASN A 467
 None
 0.85A 4fjpA-1dtdA:
undetectable		 4fjpA-1dtdA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR
(Hirudo
medicinalis) 		4 / 6 ARG B  59
GLN B  57
ILE B  21
ASP B   6
 None
 0.99A 4w5qA-1dtdB:
0.6		 4w5qA-1dtdB:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR
(Hirudo
medicinalis) 		4 / 6 ARG B  59
GLN B  57
ILE B  21
ASP B   6
 None
 0.99A 4w5tA-1dtdB:
0.0		 4w5tA-1dtdB:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 THR A 433
LEU A 435
ALA A 434
LEU A 462
LEU A 653
 None
 0.98A 4xi3C-1dtdA:
undetectable		 4xi3C-1dtdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 ASN A 393
VAL A 392
ILE A 423
ASN A 467
SER A 610
 None
 1.39A 4xueA-1dtdA:
undetectable		 4xueA-1dtdA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 ASN A 404
VAL A 392
ILE A 423
ASN A 467
SER A 610
 None
 1.31A 4xueA-1dtdA:
undetectable		 4xueA-1dtdA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR
(Hirudo
medicinalis) 		4 / 6 ARG B  59
GLN B  57
ILE B  21
ASP B   6
 None
 1.11A 4z4dA-1dtdB:
0.2		 4z4dA-1dtdB:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR
(Hirudo
medicinalis) 		4 / 7 ARG B  59
GLN B  57
ILE B  21
ASP B   6
 None
 1.05A 4z4gA-1dtdB:
0.1		 4z4gA-1dtdB:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR
(Hirudo
medicinalis) 		4 / 5 ARG B  59
GLN B  57
ILE B  21
ASP B   6
 None
 1.08A 4z4hA-1dtdB:
0.2		 4z4hA-1dtdB:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 ILE A 460
VAL A 536
THR A 433
LEU A 551
HIS A 552
 None
None
None
None
ZN  A 301 ( 3.3A)
 1.23A 5esgA-1dtdA:
0.0		 5esgA-1dtdA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		5 / 12 ILE A 549
PHE A 625
ILE A 417
ALA A 547
VAL A 578
 None
 1.25A 5jkvA-1dtdA:
0.0		 5jkvA-1dtdA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR
(Hirudo
medicinalis) 		4 / 6 ARG B  59
GLN B  57
ILE B  21
ASP B   6
 None
 1.01A 6cbdA-1dtdB:
undetectable		 6cbdA-1dtdB:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens) 		4 / 6 ALA A 624
GLY A 422
THR A 466
ILE A 535
 None
 0.91A 6f8cA-1dtdA:
0.0		 6f8cA-1dtdA:
13.99