SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dtp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 5 THR A  23
GLU A 168
THR A 169
LEU A 163
 APU  A 200 ( 4.6A)
None
None
None
 1.29A 1d4fC-1dtpA:
undetectable		 1d4fC-1dtpA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 7 HIS A  21
GLY A  22
ALA A  62
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.7A)
APU  A 200 ( 3.6A)
None
 0.61A 1dmaA-1dtpA:
9.7		 1dmaA-1dtpA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 7 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.46A 1dmaA-1dtpA:
9.7		 1dmaA-1dtpA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 6 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.54A 1dmaB-1dtpA:
9.2		 1dmaB-1dtpA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 12 ILE A 124
PHE A 123
GLY A 119
LEU A 106
LEU A 114
 None
 1.42A 1fm6X-1dtpA:
undetectable		 1fm6X-1dtpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 SER A 137
VAL A  91
SER A  11
ASP A   7
 None
 1.22A 1hwiB-1dtpA:
undetectable		 1hwiB-1dtpA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 SER A 137
VAL A  91
SER A  11
ASP A   7
 None
 1.22A 1hwkA-1dtpA:
0.0		 1hwkA-1dtpA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 SER A 137
VAL A  91
SER A  11
ASP A   7
 None
 1.22A 1hwkC-1dtpA:
0.0		 1hwkC-1dtpA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 SER A 137
VAL A  91
SER A  11
ASP A   7
 None
 1.24A 1hwkD-1dtpA:
undetectable		 1hwkD-1dtpA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 5 SER A  55
PHE A  17
VAL A 147
PHE A 140
 None
 1.36A 1oipA-1dtpA:
undetectable		 1oipA-1dtpA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 5 THR A  56
SER A 146
ASP A  57
SER A 144
 None
 1.46A 2hdnA-1dtpA:
undetectable
2hdnB-1dtpA:
undetectable
2hdnD-1dtpA:
undetectable		 2hdnA-1dtpA:
16.67
2hdnB-1dtpA:
18.69
2hdnD-1dtpA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 5 SER A 144
THR A  56
SER A 146
ASP A  57
 None
 1.47A 2hdnB-1dtpA:
undetectable
2hdnC-1dtpA:
0.0
2hdnD-1dtpA:
undetectable		 2hdnB-1dtpA:
18.69
2hdnC-1dtpA:
16.67
2hdnD-1dtpA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 6 PRO A  25
ILE A  31
ASN A 166
LEU A 163
 None
APU  A 200 ( 3.7A)
None
None
 1.00A 2wekB-1dtpA:
undetectable		 2wekB-1dtpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 SER A  19
PHE A  17
VAL A  83
LEU A 159
 None
 0.99A 3ax7A-1dtpA:
0.0		 3ax7A-1dtpA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 12 GLU A 168
ALA A  77
GLY A  75
SER A  74
ASP A 176
 None
 1.32A 3ou6D-1dtpA:
undetectable		 3ou6D-1dtpA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 7 LEU A  92
VAL A 134
LEU A  88
ASP A 129
 None
 0.92A 3rgfA-1dtpA:
0.0		 3rgfA-1dtpA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 HIS A  21
GLY A  22
TYR A  54
TYR A  65
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
 0.62A 3u9hA-1dtpA:
6.3		 3u9hA-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 HIS A  21
GLY A  22
TYR A  54
TYR A  65
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
 0.68A 3u9hB-1dtpA:
6.2		 3u9hB-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 HIS A  21
GLY A  22
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.88A 3u9hB-1dtpA:
6.2		 3u9hB-1dtpA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		6 / 6 HIS A  21
GLY A  22
TYR A  54
ALA A  62
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.7A)
APU  A 200 ( 3.6A)
None
 0.50A 4ae1A-1dtpA:
24.3		 4ae1A-1dtpA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 5 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.41A 4ae1B-1dtpA:
22.9		 4ae1B-1dtpA:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 HIS A  21
GLY A  22
TYR A  54
TYR A  65
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
 0.53A 4bjcA-1dtpA:
5.6		 4bjcA-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 HIS A  21
GLY A  22
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.86A 4bjcA-1dtpA:
5.6		 4bjcA-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 7 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.81A 4hyfA-1dtpA:
5.7		 4hyfA-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 8 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.83A 4hyfB-1dtpA:
5.8		 4hyfB-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 8 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.79A 4hyfC-1dtpA:
5.8		 4hyfC-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		3 / 3 ASP A  49
ASN A  98
SER A 109
 None
 0.74A 4obwA-1dtpA:
undetectable		 4obwA-1dtpA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 11 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.46A 4rv6A-1dtpA:
6.3		 4rv6A-1dtpA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 11 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.46A 4rv6B-1dtpA:
6.6		 4rv6B-1dtpA:
20.68