SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE
(Escherichia
coli) 		5 / 11 ALA A 235
PRO A 177
ILE A  21
ALA A 223
ASP A  42
 None
PO4  A 301 (-3.9A)
None
None
None
 1.19A 2admA-1dxeA:
undetectable		 2admA-1dxeA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE
(Escherichia
coli) 		5 / 11 ALA A 235
PRO A 177
ILE A  21
ALA A 223
ASP A  42
 None
PO4  A 301 (-3.9A)
None
None
None
 1.21A 2admB-1dxeA:
undetectable		 2admB-1dxeA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE
(Escherichia
coli) 		5 / 11 ARG A 128
ALA A  51
LEU A  65
GLN A  61
PHE A  58
 None
 1.39A 3jwqA-1dxeA:
undetectable
3jwqD-1dxeA:
undetectable		 3jwqA-1dxeA:
20.36
3jwqD-1dxeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE
(Escherichia
coli) 		5 / 9 ILE A 202
ILE A 199
TYR A 226
ALA A 181
LEU A 180
 None
 1.10A 3ozvB-1dxeA:
undetectable		 3ozvB-1dxeA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE
(Escherichia
coli) 		4 / 6 HIS A  50
GLU A 101
ASP A 159
ASP A 179
 None
None
None
MG  A 901 (-3.2A)
 1.28A 4blvA-1dxeA:
undetectable		 4blvA-1dxeA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE
(Escherichia
coli) 		4 / 9 ALA A 235
LEU A  96
LEU A 149
ILE A 173
 None
 0.89A 4xtaA-1dxeA:
0.0		 4xtaA-1dxeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE
(Escherichia
coli) 		3 / 3 LYS A 211
ILE A 173
ILE A 152
 None
 0.71A 4y0qA-1dxeA:
0.0		 4y0qA-1dxeA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE
(Escherichia
coli) 		5 / 8 ILE A  21
VAL A  76
ILE A 148
ILE A  84
PHE A  10
 None
 1.34A 5hi2A-1dxeA:
undetectable		 5hi2A-1dxeA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE
(Escherichia
coli) 		3 / 3 HIS A 201
ASN A 204
ALA A 208
 None
 0.41A 5n4tB-1dxeA:
1.5		 5n4tB-1dxeA:
24.03