SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 GLY A  17
GLY A 316
ILE A 145
GLY A  14
ALA A  21
 FAD  A 480 (-3.2A)
FAD  A 480 ( 4.0A)
None
FAD  A 480 ( 4.7A)
None
 1.09A 1jg2A-1dxlA:
4.2		 1jg2A-1dxlA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 ILE A  12
GLY A  13
GLY A  15
THR A 147
ALA A  22
 None
FAD  A 480 ( 3.8A)
FAD  A 480 (-3.9A)
FAD  A 480 (-4.0A)
None
 1.10A 1nv8A-1dxlA:
4.4		 1nv8A-1dxlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		3 / 3 LYS A 234
ILE A 212
THR A 239
 None
 0.87A 1rx3A-1dxlA:
0.2		 1rx3A-1dxlA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 5 SER A  60
GLU A 191
TYR A 356
SER A 167
 None
FAD  A 480 ( 4.6A)
FAD  A 480 (-4.7A)
FAD  A 480 (-3.7A)
 1.23A 1vidA-1dxlA:
4.3		 1vidA-1dxlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 LEU A 284
ASP A 317
GLY A  15
GLY A  18
ILE A  11
 FAD  A 480 ( 4.9A)
FAD  A 480 (-2.9A)
FAD  A 480 (-3.9A)
None
None
 1.10A 2o4kA-1dxlA:
0.0		 2o4kA-1dxlA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 6 ARG A 277
ILE A  51
LEU A  98
TYR A  19
 FAD  A 480 (-3.5A)
None
None
None
 1.00A 2ya7A-1dxlA:
0.0		 2ya7A-1dxlA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 6 ARG A 277
ILE A  51
LEU A  98
TYR A  19
 FAD  A 480 (-3.5A)
None
None
None
 1.01A 2ya7B-1dxlA:
0.0		 2ya7B-1dxlA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 6 ARG A 277
ILE A  51
LEU A  98
TYR A  19
 FAD  A 480 (-3.5A)
None
None
None
 1.00A 2ya7D-1dxlA:
0.0		 2ya7D-1dxlA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 ILE A 145
ILE A 144
ALA A 314
ALA A 325
VAL A  20
 None
None
None
FAD  A 480 (-3.5A)
None
 1.08A 2yvlA-1dxlA:
3.9		 2yvlA-1dxlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 ILE A 145
ILE A 144
GLY A 316
ALA A 314
ALA A 325
 None
None
FAD  A 480 ( 4.0A)
None
FAD  A 480 (-3.5A)
 0.99A 2yvlA-1dxlA:
3.9		 2yvlA-1dxlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 ILE A 145
ILE A 144
GLY A 316
ALA A 314
VAL A  20
 None
None
FAD  A 480 ( 4.0A)
None
None
 1.00A 2yvlB-1dxlA:
4.1		 2yvlB-1dxlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 ILE A 145
ILE A 144
GLY A 316
ALA A 325
VAL A  20
 None
None
FAD  A 480 ( 4.0A)
FAD  A 480 (-3.5A)
None
 1.08A 2yvlB-1dxlA:
4.1		 2yvlB-1dxlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		6 / 12 ILE A 145
ILE A 144
GLY A 316
ALA A 314
ALA A 325
VAL A  20
 None
None
FAD  A 480 ( 4.0A)
None
FAD  A 480 (-3.5A)
None
 1.12A 2yvlC-1dxlA:
3.8		 2yvlC-1dxlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 ASN A   7
THR A  32
VAL A 111
ILE A 126
THR A 136
 None
 1.41A 3elzA-1dxlA:
undetectable		 3elzA-1dxlA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 ASN A   7
THR A  32
VAL A 111
ILE A 126
THR A 136
 None
 1.41A 3elzC-1dxlA:
undetectable		 3elzC-1dxlA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 ASN A   7
THR A  32
VAL A 111
ILE A 126
THR A 136
 None
 1.41A 3em0A-1dxlA:
1.4		 3em0A-1dxlA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 10 VAL A 271
GLY A 243
VAL A 242
VAL A 206
ILE A 183
 None
 1.09A 3oxvB-1dxlA:
undetectable		 3oxvB-1dxlA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
 None
 0.96A 4fp9A-1dxlA:
undetectable		 4fp9A-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
 None
 0.96A 4fp9C-1dxlA:
undetectable		 4fp9C-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
 None
 0.96A 4fp9D-1dxlA:
undetectable		 4fp9D-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
 None
 0.97A 4fp9F-1dxlA:
undetectable		 4fp9F-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 GLY A 248
LEU A 272
GLY A 169
PRO A 177
LEU A 173
 None
 0.98A 4fzvA-1dxlA:
undetectable		 4fzvA-1dxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 5 TYR A 117
ILE A  35
ASN A 285
ILE A  12
 FAD  A 480 (-3.7A)
None
None
None
 0.87A 4jtpA-1dxlA:
0.0		 4jtpA-1dxlA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 6 ALA A 387
ILE A 417
GLY A 399
ILE A 470
 None
 0.82A 4r21A-1dxlA:
undetectable		 4r21A-1dxlA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 GLU A  36
GLY A  13
TYR A  19
ILE A  12
ILE A 144
 FAD  A 480 (-3.6A)
FAD  A 480 ( 3.8A)
None
None
None
 1.48A 4xudA-1dxlA:
4.1		 4xudA-1dxlA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 7 ILE A 102
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A 480 (-3.2A)
None
 0.84A 5a06A-1dxlA:
2.7		 5a06A-1dxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 7 ILE A 102
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A 480 (-3.2A)
None
 0.83A 5a06C-1dxlA:
2.1		 5a06C-1dxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 7 ILE A 102
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A 480 (-3.2A)
None
 0.83A 5a06E-1dxlA:
2.7		 5a06E-1dxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 7 ILE A 102
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A 480 (-3.2A)
None
 0.85A 5a06F-1dxlA:
2.1		 5a06F-1dxlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 12 SER A  53
GLY A 169
ALA A 170
SER A 166
LEU A 272
 FAD  A 480 ( 4.8A)
None
None
None
None
 1.10A 5jvzB-1dxlA:
0.0		 5jvzB-1dxlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 10 TYR A 313
ILE A 144
ILE A 145
ILE A 126
ILE A  35
 None
 1.08A 5murE-1dxlA:
undetectable		 5murE-1dxlA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 8 THR A  44
GLY A  43
GLY A  15
GLU A 329
 FAD  A 480 (-3.9A)
FAD  A 480 (-3.2A)
FAD  A 480 (-3.9A)
None
 0.68A 5vw9A-1dxlA:
3.5		 5vw9A-1dxlA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 8 ILE A 417
PHE A 385
ASN A 388
PRO A 420
 None
 1.10A 5x23A-1dxlA:
0.0		 5x23A-1dxlA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		5 / 7 GLY A  42
GLY A  15
PRO A  16
GLY A  17
GLY A  18
 None
FAD  A 480 (-3.9A)
FAD  A 480 (-3.8A)
FAD  A 480 (-3.2A)
None
 0.97A 6ag0A-1dxlA:
undetectable		 6ag0A-1dxlA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1dxl DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pisum
sativum) 		4 / 8 GLY A 140
THR A  32
VAL A 336
LEU A 339
 None
 0.80A 6czmD-1dxlA:
0.0
6czmF-1dxlA:
0.0		 6czmD-1dxlA:
22.50
6czmF-1dxlA:
22.50