SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1dxx DYSTROPHIN
(Homo
sapiens) 		5 / 8 ALA A  80
LEU A  54
LEU A  53
VAL A  25
ILE A  37
 None
 1.42A 2uxpA-1dxxA:
undetectable		 2uxpA-1dxxA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 1dxx DYSTROPHIN
(Homo
sapiens) 		4 / 6 LEU A 108
THR A 107
PHE A  41
ASP A  15
 None
 1.11A 2wm3A-1dxxA:
undetectable		 2wm3A-1dxxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1dxx DYSTROPHIN
(Homo
sapiens) 		5 / 12 ILE A  94
ILE A  99
GLY A  47
LEU A  53
LEU A  84
 None
 1.15A 3em0B-1dxxA:
undetectable		 3em0B-1dxxA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1dxx DYSTROPHIN
(Homo
sapiens) 		4 / 7 SER A 142
VAL A 144
VAL A 243
TRP A 143
 None
 1.26A 3n61A-1dxxA:
undetectable
3n61B-1dxxA:
undetectable		 3n61A-1dxxA:
21.89
3n61B-1dxxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1dxx DYSTROPHIN
(Homo
sapiens) 		5 / 10 LEU A  53
ALA A  80
GLY A  95
ILE A  94
LEU A  50
 None
 0.83A 3ogpA-1dxxA:
undetectable		 3ogpA-1dxxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1dxx DYSTROPHIN
(Homo
sapiens) 		5 / 12 LEU A 110
LEU A  53
LEU A  54
ILE A  99
LEU A  40
 None
 1.20A 3olsB-1dxxA:
undetectable		 3olsB-1dxxA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1dxx DYSTROPHIN
(Homo
sapiens) 		5 / 10 ILE A 111
ILE A 115
LEU A 116
ILE A  99
ASN A 103
 None
 1.40A 5vkqA-1dxxA:
0.0
5vkqD-1dxxA:
0.0		 5vkqA-1dxxA:
9.27
5vkqD-1dxxA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1dxx DYSTROPHIN
(Homo
sapiens) 		5 / 10 ILE A  99
ASN A 103
ILE A 111
ILE A 115
LEU A 116
 None
 1.41A 5vkqA-1dxxA:
0.0
5vkqB-1dxxA:
0.0		 5vkqA-1dxxA:
9.27
5vkqB-1dxxA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1dxx DYSTROPHIN
(Homo
sapiens) 		5 / 10 ILE A  99
ASN A 103
ILE A 111
ILE A 115
LEU A 116
 None
 1.40A 5vkqC-1dxxA:
0.0
5vkqD-1dxxA:
0.0		 5vkqC-1dxxA:
9.27
5vkqD-1dxxA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 1dxx DYSTROPHIN
(Homo
sapiens) 		5 / 12 LEU A  81
GLY A 109
GLU A  14
THR A 107
PHE A  41
 None
 1.27A 5x6yA-1dxxA:
0.7		 5x6yA-1dxxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1dxx DYSTROPHIN
(Homo
sapiens) 		4 / 5 GLY A  47
ASN A  76
ASP A  46
ARG A  49
 None
 1.31A 6dwdB-1dxxA:
0.0
6dwdD-1dxxA:
0.0		 6dwdB-1dxxA:
16.52
6dwdD-1dxxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1dxx DYSTROPHIN
(Homo
sapiens) 		5 / 9 LEU A 131
THR A 134
ILE A 139
VAL A 243
ILE A 245
 None
 1.30A 6ef6A-1dxxA:
undetectable		 6ef6A-1dxxA:
18.99