SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		5 / 11 LEU A 292
PHE A 195
ALA A 219
VAL A 290
MET A 243
 None
 1.23A 1hbpA-1dxyA:
0.0		 1hbpA-1dxyA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		3 / 3 ASN A 216
ALA A 242
ASN A 246
 None
 0.68A 1n4fA-1dxyA:
undetectable		 1n4fA-1dxyA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 6 ARG A  75
ILE A   3
PHE A  16
GLU A  28
 None
 1.41A 1nsiA-1dxyA:
0.0
1nsiB-1dxyA:
0.0		 1nsiA-1dxyA:
21.69
1nsiB-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 6 PHE A  16
GLU A  28
ARG A  75
ILE A   3
 None
 1.43A 1nsiA-1dxyA:
0.0
1nsiB-1dxyA:
0.0		 1nsiA-1dxyA:
21.69
1nsiB-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 6 ARG A  75
ILE A   3
PHE A  16
GLU A  28
 None
 1.44A 1nsiC-1dxyA:
0.0
1nsiD-1dxyA:
0.0		 1nsiC-1dxyA:
21.69
1nsiD-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 6 PHE A  16
GLU A  28
ARG A  75
ILE A   3
 None
 1.43A 1nsiC-1dxyA:
0.0
1nsiD-1dxyA:
0.0		 1nsiC-1dxyA:
21.69
1nsiD-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		5 / 12 ILE A 201
VAL A 229
LEU A 252
VAL A 255
THR A 240
 None
 0.95A 2aw1A-1dxyA:
undetectable		 2aw1A-1dxyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		3 / 3 THR A 153
PRO A 178
TYR A 188
 None
 0.98A 2dxrA-1dxyA:
1.9		 2dxrA-1dxyA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		5 / 10 ALA A 109
THR A 113
VAL A 148
VAL A 150
ILE A 201
 None
 1.03A 2nnjA-1dxyA:
undetectable		 2nnjA-1dxyA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		5 / 10 ALA A 109
VAL A 148
VAL A 150
ILE A 201
VAL A 200
 None
 1.06A 2nnjA-1dxyA:
undetectable		 2nnjA-1dxyA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 ARG A  75
ILE A   3
PHE A  16
GLU A  28
 None
 1.37A 2nsiA-1dxyA:
0.0
2nsiB-1dxyA:
undetectable		 2nsiA-1dxyA:
21.69
2nsiB-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 PHE A  16
GLU A  28
ARG A  75
ILE A   3
 None
 1.41A 2nsiA-1dxyA:
0.0
2nsiB-1dxyA:
undetectable		 2nsiA-1dxyA:
21.69
2nsiB-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 ARG A  75
ILE A   3
PHE A  16
GLU A  28
 None
 1.39A 2nsiC-1dxyA:
0.0
2nsiD-1dxyA:
0.0		 2nsiC-1dxyA:
21.69
2nsiD-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 PHE A  16
GLU A  28
ARG A  75
ILE A   3
 None
 1.40A 2nsiC-1dxyA:
0.0
2nsiD-1dxyA:
0.0		 2nsiC-1dxyA:
21.69
2nsiD-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		5 / 11 SER A 198
LEU A 252
ILE A 201
THR A 113
LEU A 117
 None
 1.38A 2v0mD-1dxyA:
0.0		 2v0mD-1dxyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 ARG A  75
ILE A   3
PHE A  16
GLU A  28
 None
 1.42A 3e7gA-1dxyA:
0.0
3e7gB-1dxyA:
0.0		 3e7gA-1dxyA:
21.69
3e7gB-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 PHE A  16
GLU A  28
ARG A  75
ILE A   3
 None
 1.46A 3e7gA-1dxyA:
0.0
3e7gB-1dxyA:
0.0		 3e7gA-1dxyA:
21.69
3e7gB-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 ARG A  75
ILE A   3
PHE A  16
GLU A  28
 None
 1.44A 3e7gC-1dxyA:
0.0
3e7gD-1dxyA:
0.0		 3e7gC-1dxyA:
21.69
3e7gD-1dxyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 5 HIS A 183
ASP A 187
TYR A 188
PRO A 178
 None
 1.49A 3fo7A-1dxyA:
undetectable		 3fo7A-1dxyA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 5 HIS A 183
ASP A 187
TYR A 188
PRO A 178
 None
 1.49A 3h1xA-1dxyA:
undetectable		 3h1xA-1dxyA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		5 / 10 GLY A 168
ALA A 169
VAL A 200
VAL A 150
VAL A 148
 None
 1.16A 3nu9B-1dxyA:
undetectable		 3nu9B-1dxyA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		5 / 12 HIS A 204
GLY A 157
ASP A 202
ALA A 106
SER A 293
 None
 1.06A 3sudB-1dxyA:
undetectable		 3sudB-1dxyA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		5 / 12 HIS A 204
GLY A 157
ASP A 202
ALA A 106
ASP A 112
 None
 1.01A 3sugA-1dxyA:
undetectable		 3sugA-1dxyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 PHE A  16
GLU A  28
ARG A  75
ILE A   3
 None
 1.45A 4nosA-1dxyA:
0.0
4nosB-1dxyA:
0.0		 4nosA-1dxyA:
21.88
4nosB-1dxyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 5 THR A 264
THR A 212
HIS A 213
ASN A 231
 None
 1.40A 4pgfB-1dxyA:
4.5		 4pgfB-1dxyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		3 / 3 ALA A 218
ASN A 221
LEU A 222
 None
 0.37A 5i1nB-1dxyA:
0.0		 5i1nB-1dxyA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		3 / 3 ALA A 218
ASN A 221
LEU A 222
 None
 0.42A 5i1oA-1dxyA:
0.0		 5i1oA-1dxyA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		3 / 3 ALA A 218
ASN A 221
LEU A 222
 None
 0.49A 5i1pD-1dxyA:
0.0		 5i1pD-1dxyA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		3 / 3 GLU A  12
HIS A 305
VAL A 304
 None
 0.89A 5trqB-1dxyA:
0.0		 5trqB-1dxyA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		5 / 9 HIS A 204
VAL A 200
VAL A 148
LEU A 110
ALA A 109
 None
 1.49A 5tt3B-1dxyA:
undetectable		 5tt3B-1dxyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE
(Lactobacillus
casei) 		4 / 6 LEU A 312
VAL A 316
THR A 320
GLU A  28
 None
 0.97A 5tudD-1dxyA:
0.0		 5tudD-1dxyA:
22.69