SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1dys ENDOGLUCANASE
(Humicola
insolens) 		4 / 8 LEU A 170
ILE A  66
VAL A 134
ILE A 175
 None
 0.71A 1d4yB-1dysA:
undetectable		 1d4yB-1dysA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		4 / 6 PHE A 216
LEU A 187
VAL A 145
VAL A 200
 None
 0.81A 1e7aB-1dysA:
0.0		 1e7aB-1dysA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		6 / 12 VAL A 134
VAL A 117
ILE A 163
GLY A 164
SER A 168
LEU A 170
 None
 1.42A 1eqhA-1dysA:
0.0		 1eqhA-1dysA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		6 / 12 VAL A 134
VAL A 117
ILE A 163
GLY A 164
SER A 168
LEU A 170
 None
 1.45A 1eqhB-1dysA:
0.0		 1eqhB-1dysA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 11 ILE A 265
GLY A 184
SER A 240
GLU A 243
LEU A 193
 None
 1.36A 1kyvA-1dysA:
undetectable
1kyvB-1dysA:
undetectable		 1kyvA-1dysA:
19.35
1kyvB-1dysA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 LEU A  12
ASN A  14
VAL A  81
GLY A  82
ALA A  65
 None
 0.93A 2egvA-1dysA:
undetectable		 2egvA-1dysA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 LEU A  12
ASN A  14
VAL A  81
GLY A  82
ALA A  65
 None
 0.95A 2egvB-1dysA:
undetectable		 2egvB-1dysA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 THR A 196
LEU A 259
ILE A 213
LEU A 187
TYR A 246
 None
 1.31A 3gwxA-1dysA:
0.0		 3gwxA-1dysA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 GLU A 137
LEU A 136
ASP A 180
ASP A  92
SER A  99
 None
 1.18A 3ko0A-1dysA:
undetectable
3ko0B-1dysA:
0.0
3ko0C-1dysA:
undetectable
3ko0D-1dysA:
undetectable		 3ko0A-1dysA:
10.63
3ko0B-1dysA:
10.63
3ko0C-1dysA:
10.63
3ko0D-1dysA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 ASP A  92
SER A  99
GLU A 137
LEU A 136
ASP A 180
 None
 1.24A 3ko0G-1dysA:
0.0
3ko0H-1dysA:
undetectable
3ko0I-1dysA:
0.0
3ko0J-1dysA:
0.0		 3ko0G-1dysA:
10.63
3ko0H-1dysA:
10.63
3ko0I-1dysA:
10.63
3ko0J-1dysA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 GLU A 137
LEU A 136
ASP A 180
ASP A  92
SER A  99
 None
 1.18A 3ko0K-1dysA:
0.0
3ko0L-1dysA:
undetectable
3ko0M-1dysA:
0.0
3ko0N-1dysA:
undetectable		 3ko0K-1dysA:
10.63
3ko0L-1dysA:
10.63
3ko0M-1dysA:
10.63
3ko0N-1dysA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 ASP A  92
SER A  99
GLU A 137
LEU A 136
ASP A 180
 None
 1.21A 3ko0M-1dysA:
0.0
3ko0N-1dysA:
undetectable
3ko0O-1dysA:
undetectable
3ko0P-1dysA:
undetectable		 3ko0M-1dysA:
10.63
3ko0N-1dysA:
10.63
3ko0O-1dysA:
10.63
3ko0P-1dysA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_A_P77A203_1
(PROTEIN S100-A4)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 10 ASP A  92
SER A  99
GLU A 137
LEU A 136
ASP A 180
 None
 1.17A 3m0wA-1dysA:
undetectable
3m0wB-1dysA:
undetectable
3m0wI-1dysA:
undetectable
3m0wJ-1dysA:
undetectable		 3m0wA-1dysA:
16.23
3m0wB-1dysA:
16.23
3m0wI-1dysA:
16.23
3m0wJ-1dysA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 10 ASP A  92
SER A  99
GLU A 137
LEU A 136
ASP A 180
 None
 1.18A 3m0wC-1dysA:
undetectable
3m0wD-1dysA:
undetectable
3m0wE-1dysA:
undetectable
3m0wF-1dysA:
undetectable		 3m0wC-1dysA:
16.23
3m0wD-1dysA:
16.23
3m0wE-1dysA:
16.23
3m0wF-1dysA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_D_P77D203_1
(PROTEIN S100-A4)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 10 GLU A 137
LEU A 136
ASP A 180
ASP A  92
SER A  99
 None
 1.19A 3m0wA-1dysA:
undetectable
3m0wB-1dysA:
undetectable
3m0wC-1dysA:
undetectable
3m0wD-1dysA:
undetectable		 3m0wA-1dysA:
16.23
3m0wB-1dysA:
16.23
3m0wC-1dysA:
16.23
3m0wD-1dysA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 SER A 218
GLU A 243
PHE A 263
GLY A 188
GLY A 184
 None
 1.18A 3tegA-1dysA:
undetectable		 3tegA-1dysA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1dys ENDOGLUCANASE
(Humicola
insolens) 		4 / 7 GLY A 312
GLY A 313
TYR A 334
ASN A 284
 None
 0.93A 4fgkB-1dysA:
undetectable		 4fgkB-1dysA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 SER A  99
TYR A  86
GLN A 159
ALA A 140
GLY A 147
 None
 1.25A 4j7xA-1dysA:
3.3		 4j7xA-1dysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 SER A  99
TYR A  86
GLN A 159
ALA A 140
GLY A 147
 None
 1.26A 4j7xB-1dysA:
3.2		 4j7xB-1dysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		4 / 8 ASP A  33
ASN A  36
ALA A  37
VAL A  40
 None
 0.89A 4zbqA-1dysA:
undetectable		 4zbqA-1dysA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		4 / 6 ALA A 121
VAL A 117
TYR A 116
VAL A 134
 None
 1.07A 5eckD-1dysA:
undetectable		 5eckD-1dysA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 LEU A 259
ASN A 209
ALA A 207
ILE A 203
ILE A 167
 None
 1.25A 5eypB-1dysA:
undetectable		 5eypB-1dysA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 LEU A 259
ASN A 209
ALA A 207
ILE A 203
ILE A 167
 None
 1.29A 5nm5B-1dysA:
2.2		 5nm5B-1dysA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 8 VAL A 134
ILE A  53
LEU A  83
ILE A  62
SER A 168
 None
 1.42A 5numA-1dysA:
0.0		 5numA-1dysA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 ALA A 121
LEU A  59
ILE A  53
VAL A 134
TYR A  51
 None
 1.33A 5vlmE-1dysA:
undetectable		 5vlmE-1dysA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		3 / 3 GLY A 185
ASN A 183
ARG A 276
 None
 0.47A 5w7bD-1dysA:
3.6		 5w7bD-1dysA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 12 LEU A 259
ASN A 209
ALA A 207
ILE A 203
ILE A 167
 None
 1.21A 5xiwD-1dysA:
undetectable		 5xiwD-1dysA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1dys ENDOGLUCANASE
(Humicola
insolens) 		5 / 11 VAL A 130
ALA A 127
TYR A  51
LEU A  12
LEU A 124
 None
 1.29A 6dk1B-1dysA:
0.0		 6dk1B-1dysA:
21.58