SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1dz3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1G5Y_B_9CRB501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	1dz3	STAGE 0 SPORULATION PROTEIN A (Geobacillus stearothermophil us)	5 / 12	ILE A 51 LEU A 18 LEU A 105 PHE A 103 ILE A 81	None	1.27A	1g5yB-1dz3A: 0.5	1g5yB-1dz3A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_A_SAMA301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	1dz3	STAGE 0 SPORULATION PROTEIN A (Geobacillus stearothermophil us)	5 / 12	LEU A 105 CYH A 40 ASP A 55 ALA A 8 ALA A 34	None	1.05A	2br4A-1dz3A: 2.5	2br4A-1dz3A: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_B_SAMB301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	1dz3	STAGE 0 SPORULATION PROTEIN A (Geobacillus stearothermophil us)	5 / 12	LEU A 105 CYH A 40 ASP A 55 ALA A 8 ALA A 34	None	1.10A	2br4B-1dz3A: undetectable	2br4B-1dz3A: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M9Q_B_BEZB251_0 (SERINE PROTEASE INHIBITOR SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3)	1dz3	STAGE 0 SPORULATION PROTEIN A (Geobacillus stearothermophil us)	5 / 9	ILE A 81 ILE A 51 VAL A 5 ALA A 8 LEU A 83	None	1.08A	2m9qA-1dz3A: undetectable	2m9qA-1dz3A: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2O1O_A_RISA400_1 (PUTATIVE FARNESYL PYROPHOSPHATE SYNTHASE)	1dz3	STAGE 0 SPORULATION PROTEIN A (Geobacillus stearothermophil us)	5 / 9	LEU A 14 ASP A 9 ASP A 10 THR A 84 GLN A 88	None	1.36A	2o1oA-1dz3A: undetectable	2o1oA-1dz3A: 16.57

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1G5Y_B_9CRB501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","1dz3","STAGE 0 SPORULATION PROTEIN A","Geobacillus stearothermophilus",5,"ILE A  51;LEU A  18;LEU A 105;PHE A 103;ILE A  81","None","1.27A","1g5yB-1dz3A:0.5","1g5yB-1dz3A:20.00"],["2BR4_A_SAMA301_0","CEPHALOSPORIN HYDROXYLASE CMCI","1dz3","STAGE 0 SPORULATION PROTEIN A","Geobacillus stearothermophilus",5,"LEU A 105;CYH A  40;ASP A  55;ALA A   8;ALA A  34","None","1.05A","2br4A-1dz3A:2.5","2br4A-1dz3A:22.88"],["2BR4_B_SAMB301_0","CEPHALOSPORIN HYDROXYLASE CMCI","1dz3","STAGE 0 SPORULATION PROTEIN A","Geobacillus stearothermophilus",5,"LEU A 105;CYH A  40;ASP A  55;ALA A   8;ALA A  34","None","1.10A","2br4B-1dz3A:undetectable","2br4B-1dz3A:22.88"],["2M9Q_B_BEZB251_0","SERINE PROTEASE INHIBITOR;SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3","1dz3","STAGE 0 SPORULATION PROTEIN A","Geobacillus stearothermophilus",5,"ILE A  81;ILE A  51;VAL A   5;ALA A   8;LEU A  83","None","1.08A","2m9qA-1dz3A:undetectable","2m9qA-1dz3A:19.57"],["2O1O_A_RISA400_1","PUTATIVE FARNESYL PYROPHOSPHATE SYNTHASE","1dz3","STAGE 0 SPORULATION PROTEIN A","Geobacillus stearothermophilus",5,"LEU A  14;ASP A   9;ASP A  10;THR A  84;GLN A  88","None","1.36A","2o1oA-1dz3A:undetectable","2o1oA-1dz3A:16.57"]]