SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 7 PHE A 372
ALA A 305
LEU A 307
VAL A 327
 None
 0.95A 1hk2A-1e08A:
0.0		 1hk2A-1e08A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 8 GLY A 292
ILE A 153
SER D  62
GLN D  63
 None
 1.05A 2a8tB-1e08A:
0.0		 2a8tB-1e08A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 1e08 CYTOCHROME C553
(Desulfovibrio
vulgaris) 		4 / 5 ASP E  66
LEU E  69
LYS E  70
MET E  41
 None
None
None
HEM  E  80 (-3.6A)
 1.29A 2gj5A-1e08E:
undetectable		 2gj5A-1e08E:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 GLU A 187
TRP D  92
GLN A 174
ARG A 243
GLU A 240
 None
 1.39A 2ki5A-1e08A:
0.0		 2ki5A-1e08A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		5 / 12 GLY A  70
GLY A 380
THR A 299
ILE D  47
VAL A 383
 SF4  A   2 (-3.8A)
None
None
None
None
 1.04A 2oxtA-1e08A:
undetectable		 2oxtA-1e08A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		5 / 12 ALA A 109
GLY A 381
GLY A 297
ILE D  47
GLY A 386
 PDT  A   4 ( 3.1A)
SF4  A   3 ( 3.9A)
PDT  A   4 (-3.3A)
None
SF4  A   3 ( 4.3A)
 0.90A 2qe6A-1e08A:
undetectable		 2qe6A-1e08A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		3 / 3 ASN D 110
ARG D 112
ASP A  39
 None
 0.97A 2qe6A-1e08D:
undetectable		 2qe6A-1e08D:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		3 / 3 ASN D 110
ARG D 112
ASP A  39
 None
 0.96A 2qe6B-1e08D:
undetectable		 2qe6B-1e08D:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 8 PHE A 274
LEU A 258
PRO A 106
LEU A 134
ALA A 133
 None
 1.45A 2vcvF-1e08A:
0.0		 2vcvF-1e08A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 TYR A 190
PHE A 175
TYR A 185
PRO A 173
ALA A 377
 None
None
None
None
SF4  A   3 (-3.5A)
 1.20A 2x2nA-1e08A:
0.3		 2x2nA-1e08A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 8 GLU A 156
PHE A 296
ALA A 306
ALA A 305
 None
CYN  A   7 ( 4.2A)
None
None
 1.00A 3ax9B-1e08A:
0.0		 3ax9B-1e08A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 9 ALA A 113
VAL A 298
ILE D  47
GLY D  49
THR A 294
 None
None
None
None
CYN  A   8 ( 3.9A)
 1.12A 3el4B-1e08A:
undetectable		 3el4B-1e08A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 5 PRO A 223
VAL A 226
GLY A 205
LYS A 201
 None
 1.06A 3elzB-1e08A:
undetectable		 3elzB-1e08A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
 1.04A 3embA-1e08A:
undetectable		 3embA-1e08A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 6 GLU A 156
PHE A 296
ALA A 306
ALA A 305
 None
CYN  A   7 ( 4.2A)
None
None
 0.93A 3ns1C-1e08A:
undetectable		 3ns1C-1e08A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 8 GLU A 156
PHE A 296
ALA A 306
ALA A 305
 None
CYN  A   7 ( 4.2A)
None
None
 0.95A 3ns1L-1e08A:
0.0		 3ns1L-1e08A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.11A 3p97A-1e08A:
undetectable		 3p97A-1e08A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.14A 3p97C-1e08A:
undetectable		 3p97C-1e08A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		5 / 8 GLY A 301
GLY A 381
ILE D  47
LEU A 330
VAL A 383
 None
SF4  A   3 ( 3.9A)
None
None
None
 1.17A 3v1nA-1e08A:
undetectable		 3v1nA-1e08A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 GLN A 388
ALA A 113
ILE A 295
GLU A 304
VAL A 298
 None
None
CMO  A  10 (-4.4A)
None
None
 1.09A 4azsA-1e08A:
undetectable		 4azsA-1e08A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 GLN A 388
ALA A 113
ILE A 295
GLU A 304
VAL A 298
 None
None
CMO  A  10 (-4.4A)
None
None
 1.11A 4azwA-1e08A:
undetectable		 4azwA-1e08A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.11A 4ctjA-1e08A:
undetectable		 4ctjA-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.18A 4ctjC-1e08A:
undetectable		 4ctjC-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.10A 4ctkA-1e08A:
undetectable		 4ctkA-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 8 PHE A 147
ASN A 207
ALA A 209
LEU D  76
LEU D  71
 None
 1.28A 4ejgB-1e08A:
undetectable		 4ejgB-1e08A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		3 / 3 CYH A  76
ASN A  79
LYS A  34
 SF4  A   1 (-2.2A)
None
None
 1.15A 4k50A-1e08A:
0.0		 4k50A-1e08A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 VAL A 110
ALA A 109
GLY A  70
GLY A 381
THR A 260
 PDT  A   4 (-4.3A)
PDT  A   4 ( 3.1A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 3.9A)
None
 1.17A 4mm8A-1e08A:
0.0		 4mm8A-1e08A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 6 MET A 232
TYR A 239
GLU A 240
GLU A 245
 None
 1.26A 4r87H-1e08A:
undetectable		 4r87H-1e08A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 5 GLY A 387
THR A  74
GLY A  70
GLU A  83
 None
None
SF4  A   2 (-3.8A)
None
 1.18A 4v20A-1e08A:
0.0		 4v20A-1e08A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 10 ASP A 150
ASN D  65
VAL D  68
LEU A 210
ALA A 211
 None
 1.18A 4yhaF-1e08A:
undetectable		 4yhaF-1e08A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1e08 CYTOCHROME C553
(Desulfovibrio
vulgaris) 		4 / 4 TYR E   7
GLY E  33
SER E  77
LEU E  79
 HEM  E  80 ( 4.9A)
None
None
None
 1.30A 5bphC-1e08E:
undetectable		 5bphC-1e08E:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1e08 CYTOCHROME C553
(Desulfovibrio
vulgaris) 		4 / 6 TYR E   7
GLY E  33
SER E  77
LEU E  79
 HEM  E  80 ( 4.9A)
None
None
None
 1.25A 5bphD-1e08E:
undetectable		 5bphD-1e08E:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA611_0
(SERUM ALBUMIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		4 / 4 LYS A 201
SER A 248
LEU D  87
ALA A 209
 None
 1.12A 5dbyA-1e08A:
0.0		 5dbyA-1e08A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.10A 5e9qA-1e08A:
undetectable		 5e9qA-1e08A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.20A 5e9qC-1e08A:
undetectable		 5e9qC-1e08A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.07A 5ec8A-1e08A:
undetectable		 5ec8A-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.14A 5ec8C-1e08A:
undetectable		 5ec8C-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.08A 5ehgA-1e08A:
undetectable		 5ehgA-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.17A 5ehgC-1e08A:
undetectable		 5ehgC-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.12A 5eifA-1e08A:
undetectable		 5eifA-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.19A 5eifC-1e08A:
undetectable		 5eifC-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.02A 5eiwA-1e08A:
undetectable		 5eiwA-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.12A 5ekxB-1e08A:
undetectable		 5ekxB-1e08A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.18A 5ikmA-1e08A:
undetectable		 5ikmA-1e08A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		3 / 3 VAL A 394
GLU A 262
GLU A  83
 None
 0.94A 5jsdB-1e08A:
0.0
5jsdC-1e08A:
0.0		 5jsdB-1e08A:
20.26
5jsdC-1e08A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.15A 5kqsA-1e08A:
undetectable		 5kqsA-1e08A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 THR A 148
GLY A 208
ALA A 211
THR A 213
SER A 202
 None
 1.15A 5lf3b-1e08A:
undetectable		 5lf3b-1e08A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 THR A 148
GLY A 208
ALA A 211
THR A 213
SER A 202
 None
 1.15A 5lf3N-1e08A:
undetectable		 5lf3N-1e08A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.17A 5njvA-1e08A:
undetectable		 5njvA-1e08A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		4 / 7 LEU D  87
TYR A 214
LEU D  76
GLU D  77
 None
 0.87A 5t7bA-1e08D:
undetectable		 5t7bA-1e08D:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.15A 5vimA-1e08A:
undetectable		 5vimA-1e08A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.11A 5vimB-1e08A:
undetectable		 5vimB-1e08A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.10A 5wz2A-1e08A:
undetectable		 5wz2A-1e08A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		6 / 12 GLY A 297
GLY A  70
GLY A 386
GLY A 381
VAL A  28
ILE A 235
 PDT  A   4 (-3.3A)
SF4  A   2 (-3.8A)
SF4  A   3 ( 4.3A)
SF4  A   3 ( 3.9A)
SF4  A   2 (-4.7A)
None
 1.09A 5wz2B-1e08A:
undetectable		 5wz2B-1e08A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)
(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		5 / 12 PRO A 319
GLY A 292
ALA D  61
ALA A 149
ALA A 305
 None
None
None
CYN  A   7 ( 3.4A)
None
 1.04A 5zw4A-1e08A:
undetectable		 5zw4A-1e08A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 6 GLY A 241
ASP A 255
GLY A 205
GLY A 208
 None
 0.77A 6ag0C-1e08A:
undetectable		 6ag0C-1e08A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 5 LEU A 258
THR A 228
PRO A 108
ARG A 282
 None
None
CMO  A   9 ( 3.8A)
None
 1.37A 6ew0B-1e08A:
0.0		 6ew0B-1e08A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 5 LEU A 258
THR A 228
PRO A 108
ARG A 282
 None
None
CMO  A   9 ( 3.8A)
None
 1.37A 6ew0D-1e08A:
0.0		 6ew0D-1e08A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 5 LEU A 258
THR A 228
PRO A 108
ARG A 282
 None
None
CMO  A   9 ( 3.8A)
None
 1.37A 6ew0H-1e08A:
0.0		 6ew0H-1e08A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 5 LEU A 258
THR A 228
PRO A 108
ARG A 282
 None
None
CMO  A   9 ( 3.8A)
None
 1.37A 6ew0I-1e08A:
0.0		 6ew0I-1e08A:
14.29