SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		5 / 9 ILE A  99
PHE A  73
LEU A  72
VAL A  28
LEU A  30
 None
 1.12A 1e7aB-1e0cA:
undetectable		 1e7aB-1e0cA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		4 / 8 LEU A 215
GLU A 216
GLU A 217
ILE A 211
 None
 0.99A 1qvtA-1e0cA:
undetectable		 1qvtA-1e0cA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		3 / 3 GLN A 107
HIS A  78
ARG A  79
 None
 0.94A 1zlqA-1e0cA:
0.0		 1zlqA-1e0cA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 215
ILE A 211
ILE A 207
LEU A 238
LEU A 241
 None
 0.89A 2bdmA-1e0cA:
0.0		 2bdmA-1e0cA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 246
ILE A 211
ILE A 207
LEU A 238
LEU A 241
 None
 1.00A 2bdmA-1e0cA:
0.0		 2bdmA-1e0cA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		5 / 12 GLY A 115
GLY A  91
ILE A 207
ASP A  89
LEU A 113
 None
None
None
MG  A 378 ( 4.7A)
None
 0.94A 2yqzA-1e0cA:
undetectable		 2yqzA-1e0cA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		5 / 12 GLY A 115
GLY A  91
ILE A 207
ASP A  89
LEU A 113
 None
None
None
MG  A 378 ( 4.7A)
None
 0.95A 2yqzB-1e0cA:
undetectable		 2yqzB-1e0cA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		4 / 7 ILE A  11
LEU A 113
ARG A 109
LEU A  25
 None
 0.89A 3ag3A-1e0cA:
undetectable
3ag3J-1e0cA:
undetectable		 3ag3A-1e0cA:
20.11
3ag3J-1e0cA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GF2_A_SALA147_1
(146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		4 / 4 TYR A  87
LEU A  27
ARG A  45
TYR A  36
 None
 1.37A 3gf2A-1e0cA:
undetectable		 3gf2A-1e0cA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 158
GLY A 156
LEU A 154
ARG A 157
ASP A 162
 EDO  A 374 (-4.3A)
None
None
None
None
 1.09A 3gwwA-1e0cA:
undetectable		 3gwwA-1e0cA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		3 / 3 LEU A   7
PRO A   8
ARG A 125
 None
 0.49A 4klrB-1e0cA:
2.1		 4klrB-1e0cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		4 / 6 GLU A 225
GLY A  93
ARG A  97
GLY A  96
 None
 0.81A 5cdnA-1e0cA:
0.0
5cdnB-1e0cA:
3.5		 5cdnA-1e0cA:
18.46
5cdnB-1e0cA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		4 / 6 LEU A 102
LEU A 141
LEU A  69
PHE A  98
 None
 0.92A 5gs4A-1e0cA:
undetectable		 5gs4A-1e0cA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		4 / 6 PRO A   8
GLU A  90
ALA A 198
TYR A 240
 None
 1.08A 5igiA-1e0cA:
undetectable		 5igiA-1e0cA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		5 / 12 GLY A  91
GLY A 116
ASP A  89
ILE A 207
LEU A 241
 None
None
MG  A 378 ( 4.7A)
None
None
 1.04A 6ectA-1e0cA:
undetectable		 6ectA-1e0cA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1e0c SULFURTRANSFERASE
(Azotobacter
vinelandii) 		5 / 12 GLY A  91
GLY A 116
ASP A  89
ILE A 207
LEU A 241
 None
None
MG  A 378 ( 4.7A)
None
None
 1.02A 6ecxA-1e0cA:
undetectable		 6ecxA-1e0cA:
22.16