SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		5 / 12 MET A 309
MET A 446
ILE A 442
GLY A 488
LEU A 486
 None
 1.14A 1g50B-1e0kA:
undetectable		 1g50B-1e0kA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		4 / 7 VAL A 459
VAL A 310
ILE A 422
LEU A 502
 None
 0.92A 1iepB-1e0kA:
undetectable		 1iepB-1e0kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		5 / 8 ASP A 526
ASP A 297
ILE A 518
ILE A 295
GLY A 301
 None
 1.38A 1sh9A-1e0kA:
undetectable		 1sh9A-1e0kA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		3 / 3 GLU A 538
GLU A 543
LEU A 356
 None
 0.75A 1v8bA-1e0kA:
undetectable		 1v8bA-1e0kA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		4 / 8 ARG A 359
GLY A 330
THR A 331
ALA A 332
 None
 0.81A 2a1hA-1e0kA:
undetectable
2a1hB-1e0kA:
undetectable		 2a1hA-1e0kA:
22.79
2a1hB-1e0kA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		4 / 8 ARG A 359
GLY A 330
THR A 331
ALA A 332
 None
 0.81A 2a1hA-1e0kA:
0.0
2a1hB-1e0kA:
0.0		 2a1hA-1e0kA:
22.79
2a1hB-1e0kA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		3 / 3 LYS A 450
ASP A 526
ASP A 497
 None
 1.00A 2br4D-1e0kA:
undetectable		 2br4D-1e0kA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		5 / 8 HIS A 465
VAL A 322
ILE A 463
VAL A 310
LEU A 502
 None
 1.30A 3kp6A-1e0kA:
0.0
3kp6B-1e0kA:
undetectable		 3kp6A-1e0kA:
21.18
3kp6B-1e0kA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		5 / 11 ALA A 326
VAL A 420
GLY A 330
LEU A 339
THR A 390
 None
 1.21A 3kw2A-1e0kA:
0.1		 3kw2A-1e0kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		5 / 11 ALA A 326
VAL A 420
GLY A 330
LEU A 339
THR A 390
 None
 1.24A 3kw2B-1e0kA:
undetectable		 3kw2B-1e0kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		4 / 8 ILE A 422
LEU A 339
GLY A 330
MET A 333
 None
 0.83A 3w1wA-1e0kA:
2.5		 3w1wA-1e0kA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		3 / 3 TYR A 394
ARG A 404
LYS A 408
 None
 1.14A 4wq5B-1e0kA:
0.0		 4wq5B-1e0kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		5 / 12 MET A 309
THR A 311
ILE A 442
GLY A 488
LEU A 486
 None
 1.02A 5gs4A-1e0kA:
0.0		 5gs4A-1e0kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1e0k DNA HELICASE
(Escherichia
virus
T7) 		3 / 3 GLY A 313
GLN A 506
LYS A 318
 None
 0.99A 5imsB-1e0kA:
4.0		 5imsB-1e0kA:
17.63