SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1e0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 1e0r THERMOSOME
(Thermoplasma
acidophilum) 		4 / 6 GLU B 245
LEU B 244
VAL B 278
MET B 277
 None
 0.84A 1hk1A-1e0rB:
0.0		 1hk1A-1e0rB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1e0r THERMOSOME
(Thermoplasma
acidophilum) 		4 / 7 GLU B 245
LEU B 244
VAL B 278
MET B 277
 None
 0.88A 1hk2A-1e0rB:
0.0		 1hk2A-1e0rB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 1e0r THERMOSOME
(Thermoplasma
acidophilum) 		4 / 7 GLU B 245
LEU B 244
VAL B 278
MET B 277
 None
 0.88A 1hk3A-1e0rB:
undetectable		 1hk3A-1e0rB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1e0r THERMOSOME
(Thermoplasma
acidophilum) 		5 / 10 LEU B 342
ALA B 328
LEU B 239
LEU B 240
ILE B 308
 None
 1.27A 1pcgA-1e0rB:
undetectable		 1pcgA-1e0rB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 1e0r THERMOSOME
(Thermoplasma
acidophilum) 		5 / 9 LEU B 240
GLU B 245
ALA B 299
TYR B 302
GLU B 271
 None
 1.42A 2azqA-1e0rB:
undetectable		 2azqA-1e0rB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1e0r THERMOSOME
(Thermoplasma
acidophilum) 		6 / 12 ILE B 308
LEU B 274
ILE B 295
PRO B 243
LEU B 240
ILE B 281
 None
 1.36A 2cd2A-1e0rB:
undetectable		 2cd2A-1e0rB:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1e0r THERMOSOME
(Thermoplasma
acidophilum) 		4 / 7 ALA B 235
ASP B 234
VAL B 231
THR B 359
 None
 0.98A 4eyrA-1e0rB:
undetectable		 4eyrA-1e0rB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 1e0r THERMOSOME
(Thermoplasma
acidophilum) 		5 / 12 ILE B 334
GLN B 292
LEU B 240
VAL B 289
LEU B 244
 None
 1.15A 4g1bD-1e0rB:
undetectable		 4g1bD-1e0rB:
17.22